Urinary stone disease and obesity: Different pathologies sharing common biochemical mechanisms

Aydoğdu, Özgü

doi:10.5527/wjn.v1.i1.12

Cited by 12 publications

(15 citation statements)

References 28 publications

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“…Obesity itself also promotes urine with a low pH as well as the increased excretion of calcium, oxalate, and uric acid, thereby also promoting the formation of uric acid stones. 7 , 9 …”

Section: Discussionmentioning

confidence: 99%

Kidney stone composition in overweight and obese patients: a preliminary report

Mosli¹,

Mosli²,

Kamal³

2013

RRU

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ObjectiveTo report preliminary information on urinary stone composition in patients who are either overweight or obese with kidney stone disease.MethodsA cohort of patients (n = 138) with nephrolithiasis were prospectively followed from January 2011 for 18 months. Of those, 64 (46%) were found to be overweight with body mass index ≥ 25 kg/m2 and 74 (54%) were obese with body mass index ≥ 30 kg/m2. Stone characteristics including size, location, and composition were studied in detail, and patients’ age, weight, height, and gender were all documented. The stone size and location were studied radiologically while semiquantitative stone analysis was carried out using the DiaSys method, which involves titrimetric determination of calcium, colorimetric determination/visual assessment of oxalate, phosphate, magnesium, ammonium, uric acid, and cystine, and qualitative determination of carbonate.ResultsEighteen stones were collected from overweight and obese patients. Those obtained were either spontaneously passed (n = 2), fragments passed following shockwave lithotripsy (n = 11), extracted ureteroscopically (n = 2), or extracted by percutaneous nephrolithotomy (n = 3). About 95% of the stones contained calcium oxalate and more than half contained uric acid.ConclusionThis report confirms that kidney stones are mainly composed of calcium oxalate and uric acid in overweight and obese patients with nephrolithiasis.

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“…Obesity itself also promotes urine with a low pH as well as the increased excretion of calcium, oxalate, and uric acid, thereby also promoting the formation of uric acid stones. 7 , 9 …”

Section: Discussionmentioning

confidence: 99%

Kidney stone composition in overweight and obese patients: a preliminary report

Mosli¹,

Mosli²,

Kamal³

2013

RRU

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“…According to Ozdu Aydogdu the prevalence of urolithiasis increases with obesity. [15][16][17] The distribution of urolithiasis patients based on location of stones was mostly found in the upper urinary tract: kidneys (59.41%) and ureter (34.20%). These results are in accordance with the literature which states that stones are more likely to form in the upper urinary tract.…”

Section: Discussionmentioning

confidence: 99%

Profile of urinary tract stone in Makassar, Indonesia

Sulaksono

Syahrir²,

Palinrungi

2019

Int J Res Med Sci

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Background: Urinary tract stone disease (urolithiasis) is still a significant health issue throughout the world. In Asia, regions with very high urolithiasis incidence stretch from Sudan, Saudi Arabia, United Arab Emirates, Pakistan, India, Myanmar, Thailand, Indonesia, and Philippines. Demographic and regional variations in cases of urolithiasis may provide clues to their etiology and prevalence. The aim of this study was to determine the characteristics of urolithiasis patients and their management in Makassar.Methods: This was a single centre retrospective descriptive study using data from patient medical records at Dr. Wahidin Sudirohusodo Hospital Makassar in 2015-2017. Patients’ demographic, clinical, and management characteristics were recorded.Results: From 1,166 urolithiasis patients, author found men were more dominant than women with ratio of 2.2: 1. Age distribution were more common in the range of 40-60 years (58.32%). The distribution of patients with high Body Mass Index (BMI) were relatively common included overweight 20.5% and obese 13.81%. The majority of cases were unilateral urolithiasis (89.28%), with stones were largely found in kidney (59.41%). Extracorporeal Shock Wave Lithotripsy (ESWL) was the method more commonly performed (48.13%) followed by lithotripsy.Conclusions: This study showed that urolithiasis were commonly found in the age group of 40-60 years, predominantly male, and high BMI were relatively common. The majority of cases were unilateral urolithiasis, mostly located in kidney. Urolithiasis were mostly managed by ESWL and lithotripsy.

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“…Pada studi sebelumnya ditemukan hubungan positif antara IMT dengan kadar natrium, amonium, asam urat, dan fosfat dalam urin serta hubungan terbalik dengan pH urin. 5 Keadaan pH urin menentukan jenis bahan yang akan berpresipitasi. 6 Analisis urin (urinalisis) adalah tes yang dilakukan terhadap urin, untuk mengetahui kandungan yang terdapat dalam urin.…”

Section: Pendahuluanunclassified

“…8 Penelitian sebelumnya menemukan bahwa 63% urolitiasis pada orang obes ialah batu asam urat. 5 Keadaan obes dan hiperurisemia dipengaruhi oleh konsumsi makanan dan gaya hidup. Konsumsi purin tinggi, konsumsi protein tinggi, keadaan vaskuler, dan kegagalan ginjal untuk mengekskresi mendukung terjadinya keadaan ini.…”

Section: Hasil Penelitianunclassified

Prevalensi Kristal Urat dalam Urin pada Subjek Dewasa Muda Berat Badan Lebih dan Obes

Tedjo¹,

Rambert²,

Monga³

2020

MSJ

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Overweight and obese are conditions in which abnormal fat is accumulated in the body that may cause health problems. According to WHO, especially in the Asia-Pacific region, the BMI ≥23kg/m is considered overweight and ≥25kg/m is considered obese. This study was aimed to evaluate whether urate crystals were found in the urine of young adults with overweight and obese. This was an observational and descriptive study. Samples were chosen by using non-probability sampling with consecutive sampling type. The results showed that there were 60 young adults as subjects, consisting of 24 males (40%) dan 36 females (60%). There were 22 overweight subjects (36.7%), 24 obese-1 subjects (40%), and 14 obese-2 subjects (23.3%). Of 60 subjects, urine amorph crystals were found in 32 subjects (58.3%) meanwhile oxalate calcium crystals were found in 12 subjects (20%). In conclusion, among young adults with overweight and obese, the prevalence of urine amorph urate crystal was 58.3% and of urine oxalate calcium crystal was 20%.Keywords: overweight, obese, urine crystal, amorphous urate crystal, calcium oxalate crystal Abstrak: Berat badan lebih dan obes adalah keadaan akumulasi lemak abnormal atau berlebih yang dapat mengganggu kesehatan. Menurut WHO, khususnya untuk area Asia-Pasifik, seseorang dikatakan tergolong berat badan lebih jika IMT-nya ≥23kg/m2 dan obes jika ≥25kg/m. Penelitian ini bertujuan untuk mengevaluasi adanya kristal urat dalam urin dewasa muda dengan berat badan lebih dan obes. Jenis penelitian ialah deskriptif observasional. Sampel diperoleh dengan menggunakan non-probability sampling jenis consecutive sampling. Hasil penelitian menda-patkan sebanyak 60 dewasa muda yang memenuhi kriteria inklusi penelitian, terdiri dari 24 orang laki-laki (40%) dan 36 orang perempuan (60%). Di antaranya terdapat 22 orang (36,7%) berat badan lebih, 24 orang (40%) obes 1, dan 14 orang (23,3%) obes 2. Dari 60 subyek, ditemukan kristal urat amorf pada 32 orang (58,3%) dan kalsium oksalat pada 12 orang (20%). Simpulan penelitian ini ialah pada dewasa muda dengan berat badan lebih dan obes, prevalensi kristal urat amorf urin sebesar 58,3% dan kristal kalsium oksalat urin sebesar 20%.Kata kunci: berat badan lebih, obes, kristal urin

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Urinary stone disease and obesity: Different pathologies sharing common biochemical mechanisms

Cited by 12 publications

References 28 publications

Kidney stone composition in overweight and obese patients: a preliminary report

Kidney stone composition in overweight and obese patients: a preliminary report

Profile of urinary tract stone in Makassar, Indonesia

Prevalensi Kristal Urat dalam Urin pada Subjek Dewasa Muda Berat Badan Lebih dan Obes

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