2003
DOI: 10.1016/s1056-8727(02)00169-1
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Urinary sorbitol measurement and the effect of an aldose reductase inhibitor on its concentration in the diabetic state

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Cited by 10 publications
(8 citation statements)
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“…5 shows the fluorescence intensity versus the variation in the concentration of β-NAD + . 10 Thus, a photomultiplier tube was required for measuring at low concentration of sorbitol. For low concentrations of β-NAD + , the enzymatic reaction rate and the NADH production decreased.…”
Section: Optimization Of the Sorbitol Biosensormentioning
confidence: 99%
“…5 shows the fluorescence intensity versus the variation in the concentration of β-NAD + . 10 Thus, a photomultiplier tube was required for measuring at low concentration of sorbitol. For low concentrations of β-NAD + , the enzymatic reaction rate and the NADH production decreased.…”
Section: Optimization Of the Sorbitol Biosensormentioning
confidence: 99%
“…We have previously reported an improved fluorometric and enzymatic method for measuring urinary sorbitol concentrations, which showed good sensitivity and reproducibility (Nakano et al 2003) and confirmed that urinary sorbitol excretion and whole blood sorbitol levels in diabetic patients were significantly higher than those in nondiabetic controls, and that the difference was more significant in urine than in whole blood (Nakano et al 2003). In the present study, we measured urinary sorbitol and NAG excretion as well as whole blood sorbitol concentration, and evaluated their correlation with AR activity in spontaneously generated diabetic WBN-kob rats.…”
Section: Discussionmentioning
confidence: 99%
“…To estimate the glucose metabolic state of the whole body and peripheral tissues, many investigators have determined sorbitol levels in various tissues, such as the erythrocytes, peripheral nerves, the lens, the retina and renal tissues, and analyzed the correlation between sorbitol levels and diabetic complications (Malone et al 1980, Greene et al 1985, Naeser & Brolin 1991, Stevens et al 1995. Elevated levels of urinary sorbitol excretion measured by gas chromatography (Yoshii et al 2001) or using the improved method (Nakano et al 2003) were also observed in the diabetic patient.…”
Section: Introductionmentioning
confidence: 99%
“…As for the available clinical data, it has been previously reported that blood and serum sorbitol levels are higher in diabetic patients versus healthy participants, 15 17 an observation consistent with increased flux through the polyol pathway. Hayashi et al 15 also showed a significant correlation between erythrocyte sorbitol concentrations and both blood glucose levels and HbA1c concentrations.…”
mentioning
confidence: 83%