Urinary selenium concentrations

Alaejos, M. Sanz; Romero, Carlos Dı́az

doi:10.1093/clinchem/39.10.2040

Cited by 131 publications

(58 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6][7][8][9] In contrast, the urinary selenium concentration was in the reference range; yet because of polyuria, daily loss of selenium was greater than that reported for healthy adults. 10 For manganese and nickel, the urine concentration and daily excretion exceeded that of reference populations. [11][12][13]…”

Section: Urine Concentration and Loss Of Trace Elements After Traumatmentioning

confidence: 96%

“…POLY patients lost more total selenium than reference amounts of 30-75 µg/d. 10,36,37 The loss by trauma patients also exceeded the 60 µg/d amount in PN (averaging 173% of the amount in PN). These results reinforce findings by Berger et al 38 that urinary selenium losses are increased above normal during selenium supplementation after severe traumatic injury, although we report substantially greater losses of selenium.…”

Section: Seleniummentioning

confidence: 96%

See 1 more Smart Citation

Trace Element Loss in Urine and Effluent Following Traumatic Injury

Klein

Nielsen

Moser-Veillon

2008

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

Section: Urine Concentration and Loss Of Trace Elements After Traumatmentioning

confidence: 96%

Section: Seleniummentioning

confidence: 96%

Trace Element Loss in Urine and Effluent Following Traumatic Injury

Klein

Nielsen

Moser-Veillon

2008

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

“…By reviewing data on urinary selenium from various populations, Sanz Alaejos and Diaz Romero (1993) reported a strong correlation between dietary selenium and daily urinary selenium excretion over a wide range of dietary selenium intake (r = 0.962, p < 0.001; log-log relationship). Linear equations between 24-hour urinary selenium excretion and selenium intake have been published by these authors (log-log relationships) (Yang et al, 1989b;Sanz Alaejos and Diaz Romero, 1993;Longnecker et al, 1996). However, in addition to the amount of selenium ingested, various factors influence 24-hour urinary selenium excretion, including the chemical nature of dietary selenium (Burk et al, 2006), the composition of the diet, baseline selenium status and kidney function (Oster and Prellwitz, 1990).…”

Section: Urinary Selenium Excretionmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for selenium

Products¹

2014

EFSA Journal

234

109

View full text Add to dashboard Cite

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for selenium. The levelling off of plasma selenoprotein P (SEPP1) concentration was considered indicative of an adequate supply of selenium to all tissues and to reflect saturation of the functional selenium body pool, ensuring that selenium requirement is met. This criterion was used for establishing DRVs for selenium in adults. Evidence from human studies on the relationship between selenium intake and plasma SEPP1 concentration was reviewed. Given the uncertainties in available data on this relationship, they were considered insufficient to derive an Average Requirement. An Adequate Intake (AI) of 70 µg/day for adults was set. A review of observational studies and randomised controlled trials that investigated the relationship between selenium and health outcomes did not provide evidence for additional benefits associated with selenium intake beyond that required for the levelling off of SEPP1. No specific indicators of selenium requirements were available for infants, children or adolescents. For infants aged 7-11 months, an AI of 15 µg/day was derived by extrapolating upwards from the estimated selenium intake with breast milk of younger exclusively breast-fed infants, taking into account differences in reference body weights. For children and adolescents, the AIs for selenium were extrapolated from the AI for adults by isometric scaling and application of a growth factor. AIs range from 15 µg/day for children aged one to three years to 70 µg/day for adolescents aged 15-17 years. Considering that adaptive changes in the metabolism of selenium occur during pregnancy, the AI set for adult women applies to pregnancy. For lactating women, an additional selenium intake of 15 µg/day was estimated to cover the amount of selenium secreted in breast milk, and an AI of 85 µg/day was set.

show abstract

“…It has been shown that the amount of Se in the kidney, calculated per wet mass, is 1.4 to about 3 times higher than in the liver and 6.6 to 10 times higher than in skeletal muscles (Zachara et al, 2001b). The Se level in tissues/organs depends on its daily intake, the chemical form of ingested Se and probably on other unknown factors (Lockitch, 1989;Alaejos & Romero, 1993). Thus the tissue Se level in people from seleniferous regions is much higher than in those living in low Se areas (Zachara et al, 2001b).…”

Section: Selenium In Blood Components and Se Metabolites In Urine Of mentioning

confidence: 99%

“…The predominant route of Se excretion in the healthy human is urine and feces (Robberecht & Deelstra, 1984;Alaejos & Romero, 1993). Se losses in urine represent 50-70% of the ingested element.…”

Section: Selenium In Blood Components and Se Metabolites In Urine Of mentioning

confidence: 99%

Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review.

Zachara

Gromadzińska²,

Wąsowicz³

et al. 2006

Acta Biochim Pol

View full text Add to dashboard Cite

The metabolism of oxygen in aerobic organisms leads to generation of reactive oxygen species (ROS). These entities are able to oxidize almost all classes of macromolecules, including proteins, lipids and nucleic acids. The physiological level of ROS is usually regulated by antioxidant defense mechanisms. There are at least three groups of antioxidant enzymes: superoxide dismutases, catalases and glutathione peroxidases (GSH-Pxs) which neutralize ROS. The trace elements (copper, zinc and selenium) bound to the active sites of the above listed enzymes play an important role in the antioxidant defense system. In mammals, a major function of selenium (Se) and Se-dependent GSH-Pxs is to protect cells from oxidative stress. Selenium concentrations and GSH-Px activities are altered in blood components of chronic kidney disease (CKD) patients. The Se level is frequently lower than in healthy subjects and the concentration very often decreases gradually with advancing stage of the disease. Studies on red cell GSH-Px activity in CKD patients reported its values significantly lower, significantly higher and lower or higher, but not significantly as compared with healthy subjects. On the other hand, all authors who studied plasma GSH-Px activity have shown significantly lower values than in healthy subjects. The degree of the reduction decreases gradually with the progression of the disease. High inverse correlations were seen between plasma GSH-Px activity and creatinine level. A gradual decrease in plasma GSH-Px activity in CKD patients is due to the fact that this enzyme is synthesized predominantly in the kidney and thus the impairment of this organ is the cause of the enzyme's lower activity. Se supplementation to CKD patients has a slightly positive effect in the incipient stage of the disease, but usually no effect was observed in end-stage CKD. Presently, kidney transplantation is the only treatment that may restore plasma Se level and GSH-Px activity in patients suffering from end-stage CKD. A few studies have shown that in kidney recipients, plasma Se concentration and GSH-Px activity are restored to normal values within a period of 2 weeks to 3 months following surgery and thus it can be acknowledged that Se supplementation to those patients has a positive effect on plasma GSH-Px activity.

show abstract

Urinary selenium concentrations

Cited by 131 publications

References 28 publications

Trace Element Loss in Urine and Effluent Following Traumatic Injury

Trace Element Loss in Urine and Effluent Following Traumatic Injury

Scientific Opinion on Dietary Reference Values for selenium

Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review.

Contact Info

Product

Resources

About