Urinary schistosomiasis

Bamgbola, Oluwatoyin

doi:10.1007/s00467-013-2723-1

Cited by 30 publications

(35 citation statements)

References 40 publications

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“…Herein, we propose multiple explanations for this finding. The low cure rates of PZQ could be a possibly increasing PZQ resistance in the assessed trials as observed by some authors (32)(33)(34)(35). Praziquantel is also kills the adult worms, not the immature stages; therefore, the majority of our patients on PZQ might have been harboring the immature stages at treatment time.…”

Section: Discussionmentioning

confidence: 86%

Efficacy of Different Drugs in Treating Urinary Schistosomiasis: Systematic Review and Network Meta-analysis

Fang¹,

Guo²,

Tang³

et al. 2020

Preprint

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Background Praziquantel is the current pillar for morbidity control of schistosomiasis. Artesunate and its derivatives, widely used for malaria treatment, also display antischistosomal activities. This review compares the efficacy of three drugs, namely praziquantel (PZQ), artesunate, and metrifonate in urinary schistosomiasis. Methods Databases were searched for articles comparing the effectiveness of any of the three drugs to other medications or controls in urinary schistosomiasis in children aged 18 or less. Stata software was opted to generate the network meta-analysis. Efficacy (Cure rate and egg reduction rate) was the main outcome measure. Pairwise and network meta-analysis were used to report Odds Ratios (ORs) with either 95% confidence interval (CI) for direct comparisons or 95% credible intervals (CrI) for indirect comparisons. Results The SUCRA plot for cure rate revealed that PZQ (SUCRA= 40.4%) was the fourth effective drug after albendazole 400mg (SUCRA= 71.5), metrifonate 5 mg (SUCRA= 62.2%), and metrifonate 10 mg (SUCRA= 59.7). PZQ was only superior to metrifonate 7.5 mg. ORs were PZQ 40 mg (OR 0.48; 95% CI -3.55 to 4.51; p-value 0.816), artesunate 6 mg (OR 0.06; 95% CI -5.67 to 5.79; p-value 0.983), metrifonate 5 mg (OR -1.65; 95% CI -7.52 to 4.21; p-value 0.581), metrifonate 10 mg (OR -1.76; 95% CI -8.86 to 5.34; p-value 0.628), and metrifonate 7.5 mg (OR -2.40; 95% CI -9.78 to 4.98; p-value 0.524). A similar plot for egg reduction rate showed an exclusive superiority of PZQ 40 mg (SUCRA= 94.4%), followed by metrifonate 10mg (SUCRA= 82.3%) and niridazole 25mg plus metrifonate 10mg (SUCRA= 48.6%). Conclusions Our network analysis revealed that PZQ 40 mg was the most efficient drug in reducing egg count, whereas albendazole 400mg showed the highest cure rates.

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Section: Discussionmentioning

confidence: 86%

Efficacy of Different Drugs in Treating Urinary Schistosomiasis: Systematic Review and Network Meta-analysis

Fang¹,

Guo²,

Tang³

et al. 2020

Preprint

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“…This peak in incidence recorded in early adolescence may be as result of frequent contact (swimming) in contaminated water bodies. Bangbola, [3] reports that apart from exposure, the capacity to resist new infection by eosinophil secretion of antigen specific immunoglobatin (IgE) is age dependent.…”

Section: Resultsmentioning

confidence: 99%

“…Bamgbola [3] also affirms that Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people including many children and young adults, in the tropic and subtropics. This disease is characterized by chronic infections with significant residual morbidity and is of considerate public health importance, with substantial socio-economic impacts on impoverished communities.…”

Section: Introductionmentioning

confidence: 96%

A Survey of Urinary Schistosomiasis among Secondary School Students in Jalingo Town, Jalingo Local Government Area, Taraba State

Hosea¹,

Kator²,

Geraji³

2019

AJRiZ

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This study was carried out to determine the prevalence of urinary Schistosomiasis among secondary school students in Jalingo town, Jalingo local government area, Nigeria. Ordinary centrifugal sedimentation technique was used and the deposits were examined microscopically. Data collected were analyzed using chi square. Out of the 200 samples examined, 37 (18.5%) had infection, with no significant difference (p>0.05) in infection rates between males (21.1%) and females (15.1%). Among the two schools sampled School A had the highest prevalence (22.0%) followed by School B (15.0%) with no significant difference (p>0.05). Children aged 9-12 years (60.0%) were more infected than those aged 19-21 (13.0%) (p<0.05).There was a close relationship between haematuria and positive urine samples as 72.7% of the students tested positive excreted blood in their urine (p<0.05). Major risk factors were poor hygiene, ignorance and poverty. The results of this study show that secondary school students harbor infection and are a source of transmission of Schistosomiasis in the study area. Planning and provision of drugs for treatment should be considered in disease prevention and control programmes. Community participatory health education should be encouraged as the first step in reducing infection and transmission of the disease.

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“…It is estimated that more than 200 million people are affected by schistosomiasis worldwide. This staggering prevalence makes schistosomiasis second only to malaria in terms of impact on socioeconomics and health worldwide (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal schistosomiasis may result from infection by any of the five main trematode species; however, genitourinary disease results only from S haematobium infection. Two stages characterize the life cycle of S haematobium: using mammals as definitive hosts and snails of the genus Bulinus as intermediate hosts (3,5).…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Bladder Complicating Schistosomiasis: AIRP Best Cases in Radiologic-Pathologic Correlation

2017

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A 39-year-old woman of Somali origin presented with periumbilical abdominal pain radiating to the back, suprapubic pain, and gross hematuria. The patient reported experiencing intermittent abdominal pain and hematuria for several months. Her medical history was remarkable for gastroesophageal reflux disease and a prior spontaneous abortion. She had no surgical history. Laboratory tests, including complete blood count, basic metabolic panel, and liver function tests, were within normal limits. A urinary pregnancy test yielded negative results. Pathologic Evaluation Cystoscopy was performed, demonstrating a large mass along the posterior and inferior walls of the bladder, with some extension along the left lateral wall. Approximately 2 hours of transurethral tumor resection was performed. Throughout the procedure, the ureteral orifices could not be identified. Subsequent photomicroscopy showed muscle-invasive squamous cell carcinoma and parasitic ova consistent with schistosomiasis. Editor's Note.-RadioGraphics continues to publish radiologic-pathologic case material selected from the American Institute for Radiologic Pathology (AIRP) "best case" presentations. The AIRP conducts a 4-week Radiologic Pathology Correlation Course, which is offered five times per year. On the penultimate day of the course, the best case presentation is held at the American Film Institute Silver Theater and Cultural Center in Silver Spring, Md. The AIRP faculty identifies the best cases, from each organ system, brought by the resident attendees. One or more of the best cases from each of the five courses are then solicited for publication in RadioGraphics. These cases emphasize the importance of radiologic-pathologic correlation in the imaging evaluation and diagnosis of diseases encountered at the institute and its predecessor, the Armed Forces Institute of Pathology (AFIP).

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Urinary schistosomiasis

Abstract: Schistosomiasis is the second most common socioeconomically devastating parasitic disease after malaria, affecting about 240 million residents of developing countries. In Africa, it predominantly manifests as urogenital disease, and the main infective agent is Schistosoma hematobium.

Cited by 30 publications

References 40 publications

Efficacy of Different Drugs in Treating Urinary Schistosomiasis: Systematic Review and Network Meta-analysis

Efficacy of Different Drugs in Treating Urinary Schistosomiasis: Systematic Review and Network Meta-analysis

A Survey of Urinary Schistosomiasis among Secondary School Students in Jalingo Town, Jalingo Local Government Area, Taraba State

Squamous Cell Carcinoma of the Bladder Complicating Schistosomiasis: AIRP Best Cases in Radiologic-Pathologic Correlation

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