Urinary Prolactin as a Reliable Marker for Preeclampsia, Its Severity, and the Occurrence of Adverse Pregnancy Outcomes

Leaños‐Miranda, Alfredo; Márquez-Acosta, Janeth; Cárdenas-Mondragón, Guadalupe; Chinolla-Arellano, Zarela Lizbeth; Rivera-Leaños, Roxana; Bermejo-Huerta, Sara; Romero-Arauz, Juan Fernando; Alvarez-Jiménez, Guadalupe; Ramos-León, Julio César; Ulloa‐Aguirre, Alfredo

doi:10.1210/jc.2008-0305

Cited by 68 publications

(61 citation statements)

References 30 publications

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“…PRL-V has been linked to the pregnancy-associated diseases post partum cardiomyopathy (25) and preeclampsia (21). In our investigation, the detection of PRL-V in serum samples with immunoprecipitation procedures followed by western blot analysis was either unsuccessful or not reproducible.…”

Section: Discussionmentioning

confidence: 78%

“…Investigating patients with preeclampsia, Leañ osMiranda et al reported that patients with acute renal failure exhibited higher urinary PRL concentrations and higher urinary frequencies of antiangiogenic PRLfragments than patients without diminished renal function (21). Since impaired renal function is common in patients with diabetes mellitus, increased renal elimination could explain lower systemic concentrations of PRL-V.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of prolactin-related vasoinhibin in sera from patients with diabetic retinopathy

Triebel

Huefner²,

Ramadori³

2009

European Journal of Endocrinology

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ObjectiveIn vitro experiments and in vivo studies on rodents demonstrate that N-terminal 14, 15, 16, 17, and 18 kDa fragments prolactin-related vasoinhibin (PRL-V) of human PRL are natural inhibitors of neovascularization in the retina and elsewhere. These N-terminal PRL fragments belong to a family of peptides named vasoinhibins, which act as endogenous regulators of angiogenesis and vascular function. These observations led to the hypothesis that PRL-V could play a role in the pathophysiology of diabetic retinopathy in humans. The purpose of this study was to investigate whether patients with diabetes mellitus and diabetic retinopathy have aberrant concentrations of PRL-V in the circulating blood.Research designWe performed a case–control study and developed a new technique to semi-quantitatively determine PRL-V in serum samples from 48 male subjects. The case group consisted of 21 patients with diabetes mellitus and proliferative or non-proliferative diabetic retinopathy. The control group consisted of 27 healthy subjects with no history of diabetes mellitus.MethodsFor the detection of PRL-V, we developed a new analytical method, consisting of immunologic and laser-induced fluorescence techniques.ResultsThe case group had significantly lower PRL-V serum concentrations than the control group (P=0.041). There was no significant difference between patients with proliferative and those with non-proliferative diabetic retinopathy.ConclusionWe conclude that given the antiangiogenic and antivasopermeability actions of PRL-V, the decreased serum levels of PRL-V in patients with diabetes mellitus could contribute to the development and progression of diabetic retinopathy.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Investigation of prolactin-related vasoinhibin in sera from patients with diabetic retinopathy

Triebel

Huefner²,

Ramadori³

2009

European Journal of Endocrinology

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“…26 Moreover, urinary prolactin and their isoforms of 14 and/or 16 kDa prolactin are increased in preeclampsia patients. 27 Reuwer et al proposed a recent hypothesis for the increased co-existence of PPCM and preeclampsia based on the pathophysiology of the 2 conditions sharing the same molecular pathway. 28 The current study might suggest that hypertension in pregnancy is not causative in the development of PPCM, but that a hypertensive state and PPCM are associated with other common factors.…”

Section: Discussionmentioning

confidence: 99%

Different Characteristics of Peripartum Cardiomyopathy Between Patients Complicated With and Without Hypertensive Disorders - Results From the Japanese Nationwide Survey of Peripartum Cardiomyopathy -

Kamiya

Kitakaze

Ishibashi‐Ueda

et al. 2011

Circ J

166

141

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“…For example, prolactin elevations occur in essential hypertension (10) and during the acute phase of coronary syndromes, ischemic strokes, transient ischemic attacks (11)(12)(13), and preeclampsia (14,15), playing a causative role in the heart failure that accompanies postpartum cardiomyopathy (16). Prolactin levels predicted major cardiovascular events in men with erectile dysfunction (17), and increased expression of prolactin receptors was found in advanced human atherosclerotic plaques (18).…”

Section: Introductionmentioning

confidence: 99%

Prolactin Levels, Endothelial Dysfunction, and the Risk of Cardiovascular Events and Mortality in Patients with CKD

Carrero

Kyriazis

Sönmez

et al. 2012

Clinical Journal of the American Society of Nephrology

107

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SummaryBackground and objectives Both prolactin clearance and production are altered in CKD. In nonrenal populations, emerging evidence suggests that prolactin participates in the atherosclerotic process. Given the elevated cardiovascular risk of CKD, this study examined links between prolactinemia, vascular derangements, and outcomes.Design, setting, participants, & measurements This observational study was conducted in two cohorts: one with 457 nondialyzed CKD patients (mean age 52612 years; 229 men) with measurements of flow-mediated dilation (FMD) and carotid intima-media thickness and one with 173 hemodialysis patients (65612 years; 111 men) with measurements of pulse wave velocity (PWV). Patients were followed for cardiovascular events (n=146, nondialyzed cohort) or death (n=79, hemodialysis cohort).Results Prolactin levels increased along with reduced kidney function. Prolactin significantly and independently contributed to explain the variance of both FMD (in nondialyzed patients) and PWV (in hemodialysis patients), but not intima-media thickness. In Cox analyses, the risk of cardiovascular events in nondialyzed patients increased by 27% (hazard ratio [HR], 1.27; 95% confidence interval [95% CI], 1.17-1.38) for each 10 ng/ml increment of prolactin. Similarly, the risk for all-cause and cardiovascular mortality in hemodialysis patients increased by 12% (HR, 1.12; 95% CI, 1.06-1.17) and 15% (HR, 1.15; 95% CI, 1.08-1.21), respectively. This was true after multivariate adjustment for confounders and after adjustment within the purported causal pathway (FMD or PWV).Conclusions Prolactin levels directly associated with endothelial dysfunction/stiffness and with increased risk of cardiovascular events and mortality in two independent cohorts of CKD patients.

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Urinary Prolactin as a Reliable Marker for Preeclampsia, Its Severity, and the Occurrence of Adverse Pregnancy Outcomes

Abstract: Preeclampsia is characterized by increased uPRL excretion. uPRL concentrations and their isoforms appear to be suitable markers to assess the severity of preeclampsia and occurrence of adverse outcomes. PRL and and/or its isoforms might be involved in the pathophysiology of preeclampsia.

Cited by 68 publications

References 30 publications

Investigation of prolactin-related vasoinhibin in sera from patients with diabetic retinopathy

Investigation of prolactin-related vasoinhibin in sera from patients with diabetic retinopathy

Different Characteristics of Peripartum Cardiomyopathy Between Patients Complicated With and Without Hypertensive Disorders - Results From the Japanese Nationwide Survey of Peripartum Cardiomyopathy -

Prolactin Levels, Endothelial Dysfunction, and the Risk of Cardiovascular Events and Mortality in Patients with CKD

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