Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers

Tsoi, Tik Hung; Chan, Chi Fai; Chan, Wai‐Lun; Chiu, Ka Fung Peter; Wong, Wing Tak; Ng, Chi Fai; Wong, Ka‐Leung

doi:10.1371/journal.pone.0162217

Cited by 45 publications

(39 citation statements)

References 43 publications

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“…Furthermore, urine and plasma polyamine content in cancer patients can mirror intracellular levels of these metabolites, presenting an opportunity to use them as liquid biopsy biomarkers. The biomarker potential of polyamines was recently investigated using targeted analysis with LC MS/MS in colorectal [347,348], ovarian [349], and prostate cancer [350].…”

Section: Current and Emerging Technology And Biomarkersmentioning

confidence: 99%

The Translational Status of Cancer Liquid Biopsies

Bratulić

Gatto

Nielsen

2019

Regen. Eng. Transl. Med.

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Precision oncology aims to tailor clinical decisions specifically to patients with the objective of improving treatment outcomes. This can be achieved by leveraging omics information for accurate molecular characterization of tumors. Tumor tissue biopsies are currently the main source of information for molecular profiling. However, biopsies are invasive and limited in resolving spatiotemporal heterogeneity in tumor tissues. Alternative non-invasive liquid biopsies can exploit patient's body fluids to access multiple layers of tumor-specific biological information (genomes, epigenomes, transcriptomes, proteomes, metabolomes, circulating tumor cells, and exosomes). Analysis and integration of these large and diverse datasets using statistical and machine learning approaches can yield important insights into tumor biology and lead to discovery of new diagnostic, predictive, and prognostic biomarkers. Translation of these new diagnostic tools into standard clinical practice could transform oncology, as demonstrated by a number of liquid biopsy assays already entering clinical use. In this review, we highlight successes and challenges facing the rapidly evolving field of cancer biomarker research. Lay SummaryPrecision oncology aims to tailor clinical decisions specifically to patients with the objective of improving treatment outcomes. The discovery of biomarkers for precision oncology has been accelerated by high-throughput experimental and computational methods, which can inform fine-grained characterization of tumors for clinical decision-making. Moreover, advances in the liquid biopsy field allow non-invasive sampling of patient's body fluids with the aim of analyzing circulating biomarkers, obviating the need for invasive tumor tissue biopsies. In this review, we highlight successes and challenges facing the rapidly evolving field of liquid biopsy cancer biomarker research.

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Section: Current and Emerging Technology And Biomarkersmentioning

confidence: 99%

The Translational Status of Cancer Liquid Biopsies

Bratulić

Gatto

Nielsen

2019

Regen. Eng. Transl. Med.

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“…For example, polyamine signaling in multicellular systems is clearly involved in tumorigenesis (Hamon et al 2016). Regarding PAs as cancer biomarkers, several examples were reported, such as breast cancer (Takayama et al 2016), lung cancer (Fahrmann et al 2017;Min et al 2014), prostate cancer (Tsoi et al 2016) and head and neck cancer (Sugimoto et al 2010). Few papers are available in literature reporting on electrochemical determination of PAs in human tumor tissues.…”

Section: Biosensors For the Determination Polyamines In Cancermentioning

confidence: 99%

Endogenous and food-derived polyamines: determination by electrochemical sensing

et al. 2018

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Polyamines (PAs) are involved in a variety of fundamental physio-pathologic processes. The concentration of these polycations in organs and tissues depends on their endogenous production and oxidation rates, and on their intake from foods. Besides being largely accepted as markers for the progress of several pathologies, PAs may exert themselves different effects on humans, ranging from being positive to be drastically detrimental depending on the organism conditions. Thus, if the determination of polyamines content in tissue samples is of great importance as they could be indicators of several diseases, their quantification in food is fundamental for modulating the diet to respond to a specific human health status. Thus, the determination of PA content in food is increasingly urgent. Standard analytical methods for polyamine quantification are mainly based on chromatography, where high-performance liquid chromatography and gas chromatography are the most often used, involving pre-column or post-column derivatization techniques. Driven by the growing need for rapid in situ analyses, electrochemical biosensors, comprising various combinations of different enzymes or nanomaterials for the selective bio-recognition and detection, are emerging as competitors of standard detection systems. The present review is aimed at providing an up-to-date overview on the recent progresses in the development of sensors and biosensors for the detection of polyamines in human tissues and food samples. Basic principles of different electrochemical (bio)sensor formats are reported and the applications in human tissues and in foods was evidenced.

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“…We previously observed the change of metabolite concentration in salivary samples collected from PC patients [20]. Among metabolites, polyamines in non-invasively available biofluids have been reported as possible biomarkers of various cancers [21][22][23]. Elevation of urinary polyamines and the positive correlation between their concentrations in PC tissue is well known [24].…”

Section: Introductionmentioning

confidence: 95%