Urinary polyamine levels in patients with gastrointestinal malignancy

Lipton, Allan; Sheehan, Linda; Harvey, Harold A.

doi:10.1002/1097-0142(197512)36:6<2351::aid-cncr2820360612>3.0.co;2-6

Cited by 20 publications

(5 citation statements)

References 3 publications

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“…While studying metastatic tumors of the gastrointestinal tract, different levels of specific polyamines (putrescine, spermidine and spermine) were found in the urine of patients, depending on the nature and location of tumors in the abdominal cavity and pelvic area [Lipton A et al, 1975;Russel D et al, 1978]. As noted by the authors, spermidine and spermine indices determined in rather high concentrations among the patients observed, turned out to be more informative.…”

Section: Role Of Aliphatic Polyamines In Certain Malignant Neoplasmsmentioning

confidence: 95%

“…There are highly informative data on the shifts in the polyamine system, which are considered objective criteria for the diagnosis and prognosis of a number of malignant tumors [Lipton A et al, 1975;Rudman D et al, 1979;Garnica A et al, 1982;Saydjari R et al, 1989;Lawton F et al, 1990; Os-and pathogenetic therapy of malignant neoplasms, related to the polyamine metabolism disruption, are based on the tenets mentioned in the paragraphs above [Wallace H, 2009].…”

Section: Role Of Aliphatic Polyamines In Certain Malignant Neoplasmsmentioning

confidence: 99%

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Selective Administration of Polyamine-Deficient and Polyamine-Free Diets to Cancer Patients

Avagyan,

Zilfyan,

Muradyan

2023

NAMJ

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Aliphatic polyamines (putrescin, spermidine, spermine and cadaverine) play an important role in the induction of neoplastic processes leading to cell malignancy. In malignantly transformed cells, a high level of aliphatic polyamines has been observed, which ensures their steady anaplastic growth. This is precisely why elevated levels of the aforementioned polyamines are considered as diagnostic and prognostic criteria for a wide range of oncological diseases. In several developed countries, cancer patients are advised to follow a low-polyamine diet, including specifically those food products that are identified in the general nutrient registry as having low levels of aliphatic polyamines. However, when recommending such a diet, many researchers did not pay attention to the fact that in different food products, the ratio of polyamine levels often varies within very wide limits. Therefore, as some researchers report a polyamine-deficient diet prescribed to cancer patients is not always effective. We analyzed various literary sources and identified products that do not contain polyamines or contain them in very low quantities. Based on the analysis of available literary data, when patients are admitted to oncology clinics, along with generally accepted laboratory diagnostic criteria, it is necessary to include diagnostic indicators for determining the levels of aliphatic polyamines in erythrocytes and blood plasma, including putrescine, spermidine, spermine, and cadaverine. Due to this approach, oncologists and nutritionists may have a real opportunity to prescribe a selective polyamine-deficient diet. For patients with advanced cancer, we recommend the use of a polyamine-free diet instead of a polyamine-deficient one.

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Section: Role Of Aliphatic Polyamines In Certain Malignant Neoplasmsmentioning

confidence: 95%

Section: Role Of Aliphatic Polyamines In Certain Malignant Neoplasmsmentioning

confidence: 99%

Selective Administration of Polyamine-Deficient and Polyamine-Free Diets to Cancer Patients

Avagyan,

Zilfyan,

Muradyan

2023

NAMJ

View full text Add to dashboard Cite

show abstract

“…While studying metastatic tumors of the gastrointestinal tract, different levels of specific polyamines (putrescine, spermidine and spermine) were found in the urine of patients, depending on the nature and location of tumors in the abdominal cavity and pelvic area [Lipton A et al, 1975]. As noted by the authors, spermidine and spermine indices determined in rather high concentrations among the patients observed, turned out to be more informative.…”

mentioning

confidence: 90%

“…Highly informative data on the shifts in the polyamine system, considered as objective criteria for the diagnosis and prognosis of a number of malignant tumors are presented in the researches many authors [Lipton A et al, 1975;Rudman D et al, 1979;Garnica A et al, 1982;Osswald H et al, 1986;Saydjari R et al, 1989;Lawton F et al, 1990].…”

mentioning

confidence: 99%

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Potential significance of aliphatic polyamines, α-synucleins and Helicobacter Pylori in diagnostics and prognosis of some malignant tumors.

Avagyan

Zilfyan

Muradyan

et al. 2022

NAMJ

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Polyamines (putrescine, spermidine and spermine) as well as γ- and α-synucleins are currently the subject of a special comprehensive study due to their direct influence on the formation of neoplastic processes. This review article presents informative data on the role of aliphatic polyamines (putrescine, spermidine, spermine) in the induction of a number of oncological diseases with their localization in the digestive and urinary systems. Aspects related to the synthesis and aggregation of γ-synucleins into malignantly reborn cells have been discussed. The article provides information on the possible prevention of further growth of malignant cells, by inhibiting enzymatic processes responsible for the polyamine synthesis. In case of prolonged persistence of Helicobacter Pylori in the stomach, an enhanced synthesis of polyamines and cumulation in situ of oligo- and aggregated gamma synucleins occurs in mucous membrane cells. It is possible that all of the abovementioned factors in total directly and/or indirectly have a stimulating effect on the processes of the malignancy of gastric mucosal cells. The subject of special discussion was the latest literature data, according to which, under the conditions of Helicobacter Pylori persistence in the digestive tract organs, in the gastric mucosal cells an enhanced synthesis of putrescine occurs, high concentrations of which can have a co-carcinogenic effect on normally functioning target cells. From a qualitatively new point of view, the fact of cumulation in malignantly reborn cells of an aggregated gamma synuclein, which was found during Helicobacter Pylori infection, should be considered.

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The role of early diagnosis in controlling large bowel cancer.An overview

Sherlock¹,

Winawer²

1977

Cancer

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Since early diagnosis is essential to improve the cure rate for large bowel cancer, we must use all known investigative tools to make a diagnosis in symptomatic patients in addition to periodic selective investigation of high-risk groups, such a8 those with familial polyposis, inflammatory bowel disease, previous polyps or cancer. However, our goal must be more ambitious than this. If we wait until patients have symptoms of colorectal cancer, the cure rate will significantly decrease. A mass-screening approach, therefore, is needed for the asymptomatic patient. One such approach commences with the testing for occult blood in the stool followed by intensive investigation for the source of bleeding. Newer techniques. now under investigation, such as determination of CEA in colonic washings,.ptterns of enzymes in blood and other.body fluids, fluorescent cytology and tn u i h isotopic surface labeling of colonic cells, may help to identify individuals either harboring an occult neoplasm or at increased risk for the development of colon or rectal cancer. The application of these parameters and the early recognition of precancerous lesions may lead to earlier diagnosis or diagnosis in the incipient stage of disease, which, in turn, should lead to improved survival.

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Urinary polyamine levels in patients with gastrointestinal malignancy

Cited by 20 publications

References 3 publications

Selective Administration of Polyamine-Deficient and Polyamine-Free Diets to Cancer Patients

Selective Administration of Polyamine-Deficient and Polyamine-Free Diets to Cancer Patients

Potential significance of aliphatic polyamines, α-synucleins and Helicobacter Pylori in diagnostics and prognosis of some malignant tumors.

The role of early diagnosis in controlling large bowel cancer.An overview

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