Urinary Phytoestrogen Levels Are Associated with Female Hormonal Cancers: An Analysis of NHANES Data From 1999 to 2010

Lee, Alice W.; Poynor, Valerie; McEligot, Archana Jaiswal

doi:10.1080/01635581.2021.2020304

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…These findings provide compelling evidence of the harmful effects of N-EDCs on reproductive health, although beneficial effects or no correlation have also been reported [ 6 , 27 , 34 , 41 , 52 ].…”

Section: Discussionmentioning

confidence: 87%

“…Endometriosis is a disease in which tissue similar to the lining of the uterus (the endometrium) grows outside of the uterus [ 7 ]. Multiple studies have reported the negative effects of a PE-rich diet on the risk and progression of endometriosis [ 13 , 19 , 20 , 21 , 34 , 41 , 53 , 59 ]; additionally, an epidemiological study reported by Messina et al found that the incidence of endometriosis was higher in Asian women than in Caucasian women, which may be attributed to their soy-rich diet [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The toxicological effects resulting from interaction with N-EDCs have also been found in the ovaries. The authors reported polycystic ovary syndrome (PCOS), morphological changes, and impairment of folliculogenesis as the main toxicological effects [ 13 , 18 , 27 , 28 , 34 , 35 , 41 ]. A study by Křížová et al found that exposure to daidzein and genistein during the first 5 days of life induced changes in ovarian morphology in mice [ 27 ], which was consistent with the results observed for the uterus by the same authors.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, life-long exposure to N-EDCs can significantly impact the development or progression of breast cancer [18,27,52]. This is supported by a considerable number of epidemiological studies [6,34,41,42] or in vitro/in vivo studies [28,40,[43][44][45]59] that associate N-EDC exposure levels with an increased risk of breast cancer.…”

Section: The Female Reproductive System and N-edcsmentioning

confidence: 95%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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Endocrine-disrupting compounds are chemicals that alter the normal functioning of the endocrine system of living organisms. They can be natural (N-EDCs) or synthetic compounds (S-EDCs). N-EDCs can belong to different groups, such as phytoestrogens (PEs), including flavonoids, or mycotoxins originating from plants or fungi, and cyanotoxins, derived from bacteria. Humans encounter these substances in their daily lives. The aim of this rapid review (RR) is to provide a fine mapping of N-EDCs and their toxicological effects on human health in terms of various medical conditions or adverse consequences. This work is based on an extensive literature search and follows a rigorous step-by-step approach (search strategy, analysis strategy and data extraction), to select eligible papers published between 2019 and 2023 in the PubMed database, and to define a set of aspects characterizing N-EDCs and the different human target systems. Of the N-EDCs identified in this RR, flavonoids are the most representative class. Male and female reproductive systems were the targets most affected by N-EDCs, followed by the endocrine, nervous, bone and cardiovascular systems. In addition, the perinatal, pubertal and pregnancy periods were found to be particularly susceptible to natural endocrine disruptors. Considering their current daily use, more toxicological research on N-EDCs is required.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Female Reproductive System and N-edcsmentioning

confidence: 95%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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“…Genistein (GE) and daidzein (DAZ) are the two main isoflavones in soybeans, and are classified as phytoestrogens, because of the similarities of their structures to estrogens [178,179]. Studies have shown that GE and DAZ play unique roles in the treatment of postmenopausal cerebral ischemia.…”

Section: Isoflavonesmentioning

confidence: 99%

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

et al. 2022

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Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. In the past few decades, polyphenolic compounds have shown great potential in animal models of IS because of their high biocompatibility and ability to target multiple ischemic cascade signaling pathways, although low bioavailability is an issue that limits the applications of several polyphenols. Here, we review the pathophysiological changes following cerebral ischemia and summarize the research progress regarding the applications of polyphenolic compounds in the treatment of IS over the past 5 years. Furthermore, we discuss several potential strategies for improving the bioavailability of polyphenolic compounds as well as some essential issues that remain to be addressed for the translation of the related therapies to the clinic.

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Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis

Szukiewicz¹

2023

Preprint

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Phytoestrogens (PEs) are estrogen-like nonsteroidal compounds derived from plants (e.g., nuts, seeds, fruits and vegetables) and fungi that are structurally similar to 17β-estradiol. PEs bind to all types of estrogen receptors, including ERα and ERβ receptors, the nuclear receptors, and a membrane-bound estrogen receptor known as the G protein-coupled estrogen receptor (GPER). As endocrine-disrupting chemicals (EDCs) with pro‐ or antiestrogenic properties, PEs can potentially disrupt hormonal regulation of homeostasis, resulting in developmental and reproductive abnormalities. However, the lack of PEs in the diet does not result in the development of deficiency symptoms. To properly assess the benefits and risks associated with the use of a PE-rich diet, it is necessary to distinguish between endocrine disruption (endocrine-mediated adverse effects) and nonspecific effects on the endocrine system. Endometriosis is an estrogen-dependent disease of unknown etiopathogenesis, in which tissue similar to the lining of the uterus (the endometrium) grows outside of the uterus with subsequent complications being manifested as a result of local inflammatory reactions. Endometriosis affects 10–15% of women of reproductive age and is associated with chronic pelvic pain, dysmenorrhoea, dyspareunia and infertility. In this review, the endocrine-disruptive actions of PEs are reviewed in the context of endometriosis to determine whether a PE-rich diet has a positive or negative effect on the risk and course of endometriosis.

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Urinary Phytoestrogen Levels Are Associated with Female Hormonal Cancers: An Analysis of NHANES Data From 1999 to 2010

Cited by 4 publications

References 28 publications

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis

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