Urinary PGF- 2α and Carotid intima Media Thickness in Simple Obese Children: a Cross-sectional Study

Abstract

Background: Obese children of all ages show signs of low-grade chronic inflammation. Circulating acute phase reactants (CPR) and urinary PGF-2α are used to determine the severity of inflammation. Childhood obesity-related inflammation seems to have a key role in the advancement of atherosclerosis. Obesity is a key contributor in the evolution of metabolic disorder and collection of cardiovascular risk variables that may lead to heart illness and stroke. Doppler ultrasound estimations of the intima media thickness (IMT) are a practical, direct, and noninvasive method for evaluating and detecting preclinical artery wall diseases. It was connected to cardiovascular risk variables and was able to foresee the likelihood of future cardio-cerebrovascular disease. Objectives: The aim of this research was to look into inflammatory status as measured by serum highly sensitive acute phase reactants (hs-CPR), oxidative stress as measured by urinary PGF-2α, early arterial wall anomalies as measured by IMT, and associations between the above studied parameters, clinical, and anthropometric measurements. Methods: The research included 40 obese children aged 4 to 12 years who were chosen from The Outpatient Clinic of