Urinary NGAL Measured after the First Year Post Kidney Transplantation Predicts Changes in Glomerular Filtration over One-Year Follow-Up

Kielar, Małgorzata; Dumnicka, Paulina; Gala-Błądzińska, Agnieszka; Będkowska-Prokop, Alina; Ignacak, Ewa; Maziarz, Barbara; Ceranowicz, Piotr; Kuśnierz-Cabała, Beata

doi:10.3390/jcm10010043

Cited by 16 publications

(14 citation statements)

References 59 publications

(94 reference statements)

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“…The exclusion criteria were: acute kidney injury defined according the KDIGO 2011 [ 25 ], any condition requiring hospital treatment during three months before the recruitment, and signs or symptoms of any infection (including urinary tract infection) at the time of recruitment. The present study included a subset of a larger group described previously [ 26 ]; the measurements of serum sCD93 were performed in the sera of the first 78 patients recruited.…”

Section: Methodsmentioning

confidence: 99%

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

et al. 2021

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Cluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is released to body fluids in inflammation. Data on sCD93 in kidney diseases are limited. Our aim was to evaluate serum sCD93 in long-term kidney transplant recipients as a marker of inflammation and endothelial dysfunction that may be potentially useful in early recognition of graft dysfunction. Seventy-eight adult patients with functioning kidney graft and stable clinical state were examined at least one year after kidney transplantation. Serum sCD93 was measured by enzyme immunosorbent assay. Estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria were assessed at baseline and over one-year follow-up. Increased sCD93 was associated with lower baseline eGFR independently of the confounders. Moreover, sCD93 was negatively associated with eGFR during one-year follow-up in simple analysis; however, this was not confirmed after adjustment for confounders. Baseline sCD93 was positively associated with baseline albuminuria and with increased proteinuria during the follow-up. Serum sCD93 was not correlated with other studied inflammatory markers (interleukin 6, C-reactive protein, procalcitonin and C3 and C4 complement components). To the best of our knowledge, this is the first report regarding the concentrations of sCD93 in kidney transplant recipients and one of the first reports showing the inverse association between sCD93 and renal function. Serum sCD93 should be further evaluated as a diagnostic and prognostic marker in renal transplantation.

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Section: Methodsmentioning

confidence: 99%

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

et al. 2021

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“…Trailin et al were able to show that high levels of interleukin 2 in urine are associated with worsened eGFR ( 6 ). Kielar et al showed that elevated neutrophil gelatinase-associated lipocalin (NGAL) levels in the urine were associated with an eGFR loss after transplantation ( 7 ). However, sufficient biomarkers to obtain robust and validated information about long-term allograft function and to identify patients at risk, are still lacking today.…”

Section: Introductionmentioning

confidence: 99%

Dickkopf 3—A New Indicator for the Deterioration of Allograft Function After Kidney Transplantation

et al. 2022

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Evidence of tubular atrophy and interstitial fibrosis is prognostically unfavorable and associated with a premature graft loss after kidney transplantation. Recently, Dickkopf 3 (DKK3), a profibrotic glycoprotein released by stressed tubular epithelial cells, has been identified to cause IF/TA by regulating the Wnt/β-catenin signaling and seems to engage a T-cell response. The aim of our study was to determine if a correlation between DKK3 and graft function exists and if DKK3 could be a new indicator to identify patients at risk for a deterioration in graft function. Patients, transplanted between 2016 and 2018, were analyzed with regard to DKK3 in the urine and graft function (creatinine, eGFR, albuminuria). Multivariable analyzes were used including known factors influencing graft function (PRA, donor age) to stress robustness of DKK3. The 3 and 12 month DKK3 values were significant predictors for subsequent graft function up to 36 months. An increase of DKK3 from month 3 to 12 of ≥ 25% showed a higher risk of an impaired graft function, with, e.g., a reduction in eGFR of about 9–10 ml/min in contrast to patients without intensified DKK3 increase. Induction therapy has an influence on DKK3 as patients induced with a T-cell depleting therapy showed a trend toward lower DKK3 values. In summary, our study is the first investigation of DKK3 in kidney transplant recipients and was able to show that DKK3 could forecast graft function. It is recommended to investigate the potential of DKK3 as a predictor of kidney function after transplantation in further studies.

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“…Heyne et al [ 24 ], studying uNGAL in 182 outpatient renal allotransplant recipients on maintenance immunosuppression, noted that determination of urinary NGAL levels could be a parameter to differentiate acute allotransplant rejection from other causes of AKI in follow-up after kidney transplantation. Kielar et al [ 38 ], performing a study on 109 kidney recipients with stable transplant function one year after transplantation, found that uNGAL and sNGAL and NGAL/creatinine can be used to estimate the change in kidney transplant function.…”

Section: Biomarkers Of Allogeneic Kidney Transplant Rejectionmentioning

confidence: 99%

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Rogulska

Wojciechowska‐Koszko

Dołęgowska

et al. 2022

Journal of Immunology Research

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Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead to the rejection of the transplanted organ. The gold standard for evaluating rejection of the transplanted kidney by the recipient’s organism is a biopsy of this organ. However, due to the high invasiveness of this procedure, alternative diagnostic methods are being sought. Therefore, the biomarkers may play an essential predictive role in transplant rejection. A review of the most promising biomarkers for early diagnosis and prognosis prediction of allogenic kidney transplant rejection summarizes novel data on neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), C-X-C motif chemokine 10 (CXCL-10), cystatin C (CysC), osteopontin (OPN), and clusterin (CLU) and analyses the dynamics of changes of the biomarkers mentioned above in kidney diseases and the mechanism of rejection of the transplanted kidney.

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Urinary NGAL Measured after the First Year Post Kidney Transplantation Predicts Changes in Glomerular Filtration over One-Year Follow-Up

Cited by 16 publications

References 59 publications

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

Dickkopf 3—A New Indicator for the Deterioration of Allograft Function After Kidney Transplantation

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

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