Urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C measurements for early diagnosis of acute kidney injury in children admitted to PICU

Kari, Jameela A.; Shalaby, Mohamed; Sofyani, Kholoud; Sanad, Ahmad Saleh; Ossra, Albaraa Fuad; Halabi, Rayan; Aljuhani, Maha Hassan; Toffaha, Wael Mohammad; Moria, Feras Aymen; Sabry, Samar; Ahmed, Hanan AbdelAziz; Alhasan, Khalid; Sharief, Sara Nawfal; Safdar, Osama Y

doi:10.1007/s12519-017-0110-x

Cited by 25 publications

(12 citation statements)

References 26 publications

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“…Some studies have also found that exogenous NGAL protein plays a protective role in ischemia/reperfusion injury, providing a new way for the prevention and treatment of renal ischemia/reperfusion injury [27]. Kari et al demonstrated that urinary NGAL and serum Cys-C could predict AKI early in children admitted to an intensive care unit [28]. The results of our study showed that the urine NGAL level of the mild group, moderate group and severe group was higher than that of normal control group, the urine NGAL level of severe group was higher than that of mild group, and the urine NGAL level of moderate group was higher than that of mild group.…”

Section: F I G U R E 1 Roc Curve Analysis Resultsmentioning

confidence: 99%

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The Value of Urine NAG, NGAL Combined with Serum Cys-C in Early Diagnosis of Neonatal Hyperbilirubinemia-related Acute Kidney Injury

Wang¹,

Jin²,

Shen³

et al. 2020

Signa Vitae

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Objective: To explore the early diagnostic value of urinary NAG, NGAL and serum Cys-C detection for neonatal hyperbilirubinemia-related acute kidney injury (AKI) in full-term neonates with hyperbilirubinemia. Methodology: One hundred and ninety-six full-term jaundiced newborns were categorized as mild (n = 65), moderate (n = 69) or severe hyperbilirubinemia (n = 62). The severe group was divided into a non-AKI group (n = 35) and an AKI group (n = 27). Sixty-five full-term newborns with normal serum bilirubin and renal function were analyzed as a normal control group. Urine NAG, urine NGAL and serum Cys-C weremeasured. The value of urinary NAG, NGAL combined with serum Cys-C in early diagnosis of neonatal hyperbilirubinemia-related AKI was evaluated by Receiver Operating Characteristic Curve (ROC). Result: Levels of urine NAG, NGAL and serum Cys-C in the mild, moderateand severe groups were higher than those in the normal control group (p < 0.001), the above indexes levels in the severe group were higher than those in the mildand moderate groups (p < 0.001), and the above indexes levels in the moderate group were higher than those in the mild group (p < 0.001). Pearson correlation analysis showed that serum Cys-C was positively correlated with urinary NAG and urinary NGAL in AKI group (r = 0.805, p < 0.001; r = 0.864, p < 0.001); there was a positive correlation between urinary NAG and urinary NGAL in AKI group (r = 0.948, p < 0.001). AUC of urinary NAG, urinary NGAL combined with serum Cys-C in diagnosing neonatal hyperbilirubinemia-related AKI is 0.900 (95%CI: 0.824-0.976), which is higher than that of urinary NAG, urinary NGAL and serum Cys-C alone. Conclusion: Combined measurement of urine NAG, NGAL and serum Cys-C is helpful for early diagnosis of neonatal hyperbilirubinemia-related AKI.

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Section: F I G U R E 1 Roc Curve Analysis Resultsmentioning

confidence: 99%

“…Cysteine protease inhibitor C (Cys-C) is an endogenous indicator reflecting glomerular filtration rate [13]. Studies have confirmed that serum Cys-C could be used as a diagnostic tool for AKI [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Value of Urine NAG, NGAL Combined with Serum Cys-C in Early Diagnosis of Neonatal Hyperbilirubinemia-related Acute Kidney Injury

Wang¹,

Jin²,

Shen³

et al. 2020

Signa Vitae

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“…It is involved in fatty acid metabolism 12) . In patients with acute kidney injury, increased levels of urinary NGAL and LFABP can detect renal injury more sensitively than the conventional diagnostic criterion (i.e., increase of serum creatinine and/or decrease of urine output 10,16,17) . Several studies have reported that urinary LFABP levels may reflect renal injury in early stages of nephropathy in patients with diabetes, even in normoalbuminuric state 14,18) .…”

Section: Discussionmentioning

confidence: 99%

The associations of Urinary Neutrophil Gelatinase-associated Lipocalin (NGAL) and Liver-type Fatty Acid Binding Protein (L-FABP) Levels with Hematuria in Children and Adolescents

Choi¹,

Bin²,

Cho³

et al. 2019

Child Kidney Dis

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We sought to determine associations of urinary neutrophil gelatinaseassociated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP), known markers of renal injury, with hematuria in children and adolescents. Methods: A total of 112 urine samples from 72 patients aged 2 to 18 years with hematuria were enrolled in this study. Urinary concentrations of NGAL and L-FABP were measured by ELISA and compared between subjects with and without proteinuria and between subjects with and without glomerulonephritis diagnosed by renal biopsy. Results: Urinary concentrations of NGAL and L-FABP/creatinine (Cr) in subjects with proteinuria were not significantly different from those in subjects without proteinuria. They were not significant different between subjects with and without glomerulonephritis either. However, both concentrations of urinary NGAL and L-FABP/Cr were positively associated with urinary protein to creatinine ratio. Their levels had a tendency to be increased when proteinuria developed at later visits in subjects with hematuria only at initial visits. Conclusion: Monitoring urinary NGAL and L-FABP levels in addition to conventional risk factors such as proteinuria and serum creatinine might improve the prediction of renal injury in pediatric patients with hematuria.

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“…Simultaneously, the plasma NGAL concentrations increase. Urine NGAL concentrations rise quickly in AKI and dynamically change, which allows for the monitoring of kidney injury [45,46]. The NGAL measurements can have been shown to predict AKI that is caused by bacterial infection [47] and sepsis [34].…”

Section: The Markers Of Tubular Dysfunctionmentioning

confidence: 99%

Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

Wajda

Dumnicka

Maraj

et al. 2019

IJMS

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Acute kidney injury (AKI) is a serious complication of acute pancreatitis (AP), which occurs in up to 70% of patients with severe AP and significantly increases the risk of mortality. At present, AKI is diagnosed based on dynamic increase in serum creatinine and decreased urine output; however, there is a need for earlier and more accurate biomarkers. The aim of the study was to review current evidence on the laboratory tests that were studied as the potential biomarkers of AKI in AP. We also briefly summarized the knowledge coming from the studies including sepsis or ICU patients since severe acute pancreatitis is associated with systemic inflammation and organ failure. Serum cystatin C and serum or urine NGAL have been shown to predict or diagnose AKI in AP; however, this evidence come from the single center studies of low number of patients. Other markers, such as urinary kidney injury molecule-1, cell cycle arrest biomarkers (tissue inhibitor metalloproteinase-2 and urine insulin-like growth factor-binding protein 7), interleukin-18, liver-type fatty acid-binding protein, or calprotectin have been studied in other populations suffering from systemic inflammatory states. In AP, the potential markers of AKI may be significantly influenced by either dehydration or inflammation, and the impact of these factors may be difficult to distinguish from kidney injury. The subject of AKI complicating AP is understudied. More studies are needed, for both exploratory (to choose the best markers) and clinical (to evaluate the diagnostic accuracy of the chosen markers in real clinical settings).

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Urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C measurements for early diagnosis of acute kidney injury in children admitted to PICU

Abstract: uNGAL and s-Cys-C predicts AKI early in critically ill children.

Cited by 25 publications

References 26 publications

The Value of Urine NAG, NGAL Combined with Serum Cys-C in Early Diagnosis of Neonatal Hyperbilirubinemia-related Acute Kidney Injury

The Value of Urine NAG, NGAL Combined with Serum Cys-C in Early Diagnosis of Neonatal Hyperbilirubinemia-related Acute Kidney Injury

The associations of Urinary Neutrophil Gelatinase-associated Lipocalin (NGAL) and Liver-type Fatty Acid Binding Protein (L-FABP) Levels with Hematuria in Children and Adolescents

Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

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