Urinary Nerve Growth Factor in full-term, preterm and intra uterine growth restriction neonates: Association with brain growth at 30–40 days of postnatal period and with neuro-development outcome at two years. A pilot study

Aisa, Maria Cristina; Barbati, Antonella; Cappuccini, Benito; Rosa, Francesca; Gerli, Sandro; Clerici, Graziano; Kaptilnyy, Vitaly Alexandrovich; Ishenko, Anatoly Ivanovich; Renzo, Gian Carlo Di

doi:10.1016/j.neulet.2020.135459

Cited by 7 publications

(22 citation statements)

References 35 publications

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“…Some studies reported relevant clinical correlations between serum NGF levels and neurodevelopmental outcomes among the neonatal population, suggesting that these neurotrophins should be further explored as a biomarker of neuronal repair ( 20 , 39 ). Similar conclusions were drawn by Aisa et al, which correlated urinary NGF measured at 30–40 days of the postnatal period with brain growth, assessed at the same time point, and with the neurodevelopment outcome at 2 years of age evaluated by the Griffiths-II test ( 21 ). Similar investigations were conducted also by Massaro et al which correlated serum BDNF value with NDV outcome in newborns with hypoxic-ischemic encephalopathy ( 36 ).…”

Section: Discussionsupporting

confidence: 80%

“…Krey et al demonstrated that NFs' levels influence motor and cognitive function ( 12 ). In observational studies, it has been demonstrated that NGF has a positive correlation with the Bayley score at 24 months of life and brain volumes, implying that this neurotrophin can be used to identify infants at high risk of NDV ( 20 , 21 ). It has demonstrated the presence of NFs in breast milk and higher levels of NGF in breastfed infants, born with small gestational age weight ( 22 – 24 ).…”

Section: Introductionmentioning

confidence: 99%

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Early nutritional intake influences the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor in preterm newborns

Nardo

Petrella²,

Chiara³

et al. 2022

Front. Neurol.

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IntroductionParenteral nutrition (PN) may have detrimental effects on neurodevelopment in preterm newborns. Moreover, enteral nutrition (EN) seems to be protective. To understand the mechanisms of how neurological development can be influenced by the route of administration of nutritional intake, we investigated the relationship between the serum levels of the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and nutritional intake received in early life by preterm newborns.Materials and methodsSpecimens of blood were obtained at 28 days of life (DOL) for NGF/BDNF determination in neonates <32 weeks of gestation and/or with birth weight <1,500 g, consecutively observed in the neonatal intensive care unit. We analyzed the relation between amino acid content and energy intake and NGF/BDNF measurements at 28 DOL. PN protein intake was referred to as the total amounts of amino acid intake received daily.ResultsWe enrolled 20 newborns (gestational age 30.45 ± 1.76 weeks, birth weight 1,340 ± 352.63 g). Serum NGF value at 28 DOL was positively correlated with enteral protein and energy intake (r = 0.767; r = 0.746, p < 0.001), whereas, negatively correlated with parenteral amino acid and energy intake (r = −0.652, p < 0.001; r = −0.466, p < 0.05). Similar significant correlations were described between BDNF level at 28 DOL and enteral energy intake (r = 0.493, p < 0.05). Multivariate regression analysis showed that NGF level at 28 DOL depends on enteral protein and energy intake administrated in the 1st week of life.ConclusionNeurotrophin values varied according to the route of nutrition administration in preterm newborns. NGF/BDNF serum levels are influenced positively and negatively by EN and PN, respectively.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Early nutritional intake influences the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor in preterm newborns

Nardo

Petrella²,

Chiara³

et al. 2022

Front. Neurol.

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“…In this study, short intervention time and insufficient breastfeeding with a low breastfeeding rate (approximately 18.18%) may lead to the insignificant change of BDNF urine levels in the PDSP group. Another study showed that the concentrations of BDNF in the urine of preterm infants 30 to 40 days after birth were not significantly related to the neurodevelopmental outcome at 2 years of age 30. It may hint that the timing of BDNF in promoting neurodevelopment is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Urine BDNF was collected according to the procedure of the noninvasive sampling technique in a previous study. 30 The urine specimens of all infants were collected at T 0 by researchers and at T 2 by parents, transferred 1 mL to sterile tubes, and prepared for further analysis. Before discharge from the hospital, the researchers instructed the parents on how to collect and store urine.…”

Section: Bdnf Levelsmentioning

confidence: 99%

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Exploring Effect of Postdischarge Developmental Support Program on Preterm Infant Neurodevelopment and BDNF Gene DNA Methylation

Zhang¹,

Cao²,

Yue³

et al. 2022

Advances in Neonatal Care

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Background: Although developmental supportive care is an effective approach to improve the long-term psychomotor and/or neurobehavioral function of preterm infants, very limited studies have focused on the impact of after-discharge developmental support. The underlying epigenetic changes are unclear. Purpose: This study aimed to explore the preliminary effect of an evidence-based Postdischarge Developmental Support Program (PDSP) on preterm infant neurodevelopment and underlying epigenetic changes, including brain-derived neurotrophic factor (BDNF) gene-related DNA methylation and expression. Methods: In this randomized controlled pilot trial, the preterm infant-parent dyads were randomized into either the intervention group/PDSP group (n = 22) or the control group/usual care group (n = 22). The neurodevelopmental outcomes of preterm infants were measured by Ages & Stages Questionnaires. Urine BDNF concentration level was tested by the enzyme-linked immunosorbent assay. Infant saliva specimens were collected to analyze the methylation level of BDNF gene promoter I at pre- and postintervention test. Results: After PDSP intervention, the total neurodevelopmental and the 5 domain scores of the PDSP group were all significantly higher than those of the control group (P < .05). The BDNF levels decreased significantly only within control group (P = .01). The difference in BDNF concentration and methylation levels between groups was not statistically significant. Implications for Practice and Research: Postdischarge Developmental Support Program may promote the neurodevelopment of preterm infants but has no effect on BDNF's expression and gene methylation level at 3 months of corrected age. The epigenetic mechanism of PDSP needs further study using a larger sample and longer follow-up.

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Nocturnal enuresis — a new look at the old problem

Smirnova

Belyakova

Kuprienko

et al. 2023

Urology reports (St. - Petersburg)

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Nocturnal enuresis is the most common functional disorder of the urinary system in children, significantly reducing the quality of life of both patients and their parents. There are several hypotheses for the development of this disease, none of which can be taken as dominant. In this regard, Nocturnal enuresis is considered as a polyetiological condition. This review details the main factors that are associated with the development of nocturnal enuresis in children. These include hereditary predisposition, bladder dysfunction, sleep and awakening disorders, delayed maturation of central nervous system structures, disruption of the circadian rhythm of antidiuretic hormone and aquaporin-2 production. Despite many publications on nocturnal enuresis in children, many aspects of the pathogenesis of the disease remain unclear and require further study.

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Urinary Nerve Growth Factor in full-term, preterm and intra uterine growth restriction neonates: Association with brain growth at 30–40 days of postnatal period and with neuro-development outcome at two years. A pilot study

Cited by 7 publications

References 35 publications

Early nutritional intake influences the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor in preterm newborns

Early nutritional intake influences the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor in preterm newborns

Exploring Effect of Postdischarge Developmental Support Program on Preterm Infant Neurodevelopment and BDNF Gene DNA Methylation

Nocturnal enuresis — a new look at the old problem

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