Urinary Neopterin in Monoclonal Gammopathies

Denz, H.; Fuchs, Dietmar; Hausen, Arno; Huber, H.; Nachbaur, David; Reibnegger, Gilbert; Thaler, Josef; Werner, Ernst R.; Wächter, Helmut

doi:10.1515/pteridines.1990.2.2.107

Cited by 3 publications

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“…Such a phenomenon can be best explained by IFN-γ-mediated IDO expression within the tumors. This conclusion is also supported by a correlation found between neopterin concentrations and kyn/trp, which suggests that under these conditions endogenous production of IFN-γ is increased, and by the finding of an increased expression of IFN-γ in cancer patients reported earlier [77].…”

Section: Ifn-γ In Patients With Malignant Disease -Friend or Foe?supporting

confidence: 65%

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

Brandacher¹,

Winkler²,

Schroecksnadel³

et al. 2006

CDM

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Insufficient immunosurveillance is an important aspect in early tumorigenesis and in the pathogenesis of malignant disease. In the later course of cancer, the development of immunodeficiency is considered the major reason for disease progression and death. Within the anti-tumoral host defense reaction, Th1-type cytokine interferon-gamma (IFN-gamma) is of particular relevance. IFN-gamma stimulates several anti-proliferative and thus tumoricidal biochemical pathways in macrophages and other cells and also in tumor cell lines. These include inducible nitric oxide synthase, indoleamine (2, 3)-dioxygenase, an enzyme degrading the essential amino acid tryptophan, and the production of reactive oxygen species and neopterin in human macrophages and dendritic cells. Although the anti-proliferative strategy of the immune system aims to inhibit the growth of malignant cells, it can also affect T-cell response and thus contribute to the development of immunodeficiency. Accelerated degradation of tryptophan and increased production of neopterin were found to parallel the course of malignant diseases. Moreover, a higher degree of these metabolic changes characterizes poor prognosis and is associated with the development of anemia, weight loss and depressive mood in patients. Available data suggest that immunodeficiency in cancer patients may develop as a long-term side-effect of the antiproliferative and pro-apoptotic mechanisms elicited within Th1-type immune response, and enhanced production of pro-inflammatory cytokine IFN-gamma seems to be critically involved.

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Section: Ifn-γ In Patients With Malignant Disease -Friend or Foe?supporting

confidence: 65%

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

Brandacher¹,

Winkler²,

Schroecksnadel³

et al. 2006

CDM

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“…При этом маркером происходящих иммунохимических изменений, индуцируемых цитокинами, является неоптерин (НП) [9]. Исследованиями продемонстрирована клинико-диагностическая роль определения НП при различных патологических процессах [10][11][12][13].Успешный опыт применения лабораторных тестов на определение НП в клинической практике позволяет рассматривать его в качестве вспомогательного маркера активности иммуновоспалительного процесса и тяжести течения АтД и диктует необходимость проведения дальнейших исследований в этом направлении.…”

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Clinical and Diagnostic Value of Determination of Neopterin in Atopic Dermatitis in Children

Ben¹,

Yanchevskaya²,

Mesnyankina³

2018

Kuban. nauсh. med. vestnik

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Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

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High-Dose Recombinant Human Erythropoietin Stimulates Reticulocyte Production in Patients with Multiple Organ Dysfunction Syndrome

Gabriel

Kozek

Chiari

et al. 1998

The Journal of Trauma: Injury, Infection, and Critical Care

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Urinary Neopterin in Monoclonal Gammopathies

Cited by 3 publications

References 1 publication

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

Clinical and Diagnostic Value of Determination of Neopterin in Atopic Dermatitis in Children

High-Dose Recombinant Human Erythropoietin Stimulates Reticulocyte Production in Patients with Multiple Organ Dysfunction Syndrome

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Urinary Neopterin in Monoclonal Gammopathies

Cited by 3 publications

References 1 publication

Antitumoral Activity of Interferon-&#947; Involved in Impaired Immune Function in Cancer Patients

Antitumoral Activity of Interferon-&#947; Involved in Impaired Immune Function in Cancer Patients

Clinical and Diagnostic Value of Determination of Neopterin in Atopic Dermatitis in Children

High-Dose Recombinant Human Erythropoietin Stimulates Reticulocyte Production in Patients with Multiple Organ Dysfunction Syndrome

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Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients