Urinary Neopterin as a New Biochemical Marker for the Monitoring of Disease Activity and Prognosis in Membranous Nephropathy Associated with Hepatitis B Surface Antigenemia

Lin, Ching-Yuang

doi:10.1159/000185722

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…These include: various immune-mediated clinical conditions, including transplantation rejection (11); hepatitis and other viral infections, such as human immunodeficiency virus and cytomegalovirus; bacterial infections (3,12, 13); autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis; tumors, such as hepatocellular carcinoma, stomach cancer, or uroepithelial cancer (14,15); congestive heart failure; renal failure; coronary artery disease; and, myocardial infarction. Weiss et al reported that neopterin is a marker for disease progression and complication in diabetes mellitus, such as glycation end-product pentosidine, and other inflammatory molecules, such as interleukin-6 and C-reactive protein (CRP) are (16).…”

Section: Discussionmentioning

confidence: 99%

“…Neopterin levels in body fluids are elevated in a variety of diseases in which T cells or macrophages are activated (1,2). Therefore, neopterin levels can be useful for the evaluation of disease activity and prognosis in a variety of conditions (3-7). …”

Section: Introductionmentioning

confidence: 99%

“…Lin reported that increased urinary neopterin levels are related to increases in interlukin-2 and the interferon γ observed in the membranous nephropathy associated with hepatitis B, which is generally accompanied by the nephrotic syndrome or severe proteinuria (3). He noted that neopterin is not specific in this case, but it is clear that neopterin is useful in the monitoring the clinical course, or even as a prognostic marker.…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Significance of Serum and Urinary Neopterin Levels in Several Renal Diseases

et al. 2006

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Neopterin is a pyrazino-pyrimidine compound, and is known to be a marker associated with cell-mediated immunity in various diseases. We hypothesized that the levels of serum and urine neopterin would be elevated in renal disease, and would correlate with certain clinical parameters. We evaluated serum and urinary neopterin levels in patients with several renal diseases, including nephrotic syndrome (NS, n=19), chronic renal failure (CRF, n=8), end stage renal disease (ESRD, n=64) and controls (n=22). Serum neopterin was elevated in patients with CRF and ESRD, as compared to controls. Urinary neopterin levels were also found to be elevated in patients with CRF and ESRD, as compared to controls. Serum neopterin levels showed significant positive correlation with age, serum BUN and creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, serum albumin and total iron binding capacity. Urine neopterin levels exhibited positive correlation with age and serum creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, BUN and serum albumin. In conclusion, increased serum and urinary neopterin levels were found in some patients with renal disease and were correlated with certain clinical parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Clinical Significance of Serum and Urinary Neopterin Levels in Several Renal Diseases

et al. 2006

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“…Its levels are elevated in several conditions including autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis [4]; infections such as hepatitis, human immunodeficiency virus, and cytomegalovirus [5–7]; cancers like hepatocellular, gastric, and urothelial carcinomas [8, 9]; congestive heart failure; coronary artery disease and myocardial infarction and transplant rejection [10–13]. Neopterin has been reported as a marker of disease progression and complication in diabetes [14].…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease

Yadav

Sharma

Jha

2012

Mediators of Inflammation

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Background. The serum levels of neopterin, a marker associated with cell-mediated immunity are elevated in chronic kidney disease (CKD). We evaluated serum neopterin levels and investigated its association with markers of inflammation in a cross-section of CKD subjects without known cardiovascular disease. Methods. Serum neopterin levels were measured in 118 patients with stage 3–5 CKD and 41 healthy subjects with normal kidney function (HC). Patients with known cardiovascular disease were excluded. We also estimated highly sensitive CRP (hsCRP) and interluekin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the CKD subjects. All assays were done using commercially available ELISA kits. The correlation between neopterin and markers of inflammation were investigated. Results. Of the CKD population, 82 were in stage 5 (60 stage 5 D), 24 in stage 4, and 12 in stage 3. The mean age was 51.04 ± 1.3 years and 66% were males. The commonest cause of CKD was diabetes (36%). Serum neopterin levels were 5-fold higher in CKD patients as compared to HC (74.8 ± 3.6 versus 15.0 ± 2.8 nmol/L, P < 0.0001). There was a graded increase of serum neopterin from stages 3 to 4 and 5. CKD 5 D patients exhibited significantly higher levels compared to nondialysis stage 5 patients (P < 0.0001). An inverse correlation was noted between serum neopterin and eGFR (r = −0.359, P < 0.0001). Serum neopterin correlated with hsCRP (r = 0.285, P = 0.002), IL-6 (r = 0.212, P = 0.034), and IFN-γ (r = 0.32, P = 0.001) but not with TNF-α. Conclusion. Serum neopterin level is elevated and correlates with the severity of CKD. The elevation correlates with elevation of most, but not all, inflammatory markers. Its role in future development of cardiovascular disease and modulation with anti-inflammatory therapies needs further studies.

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“…Neopterin has been reported to be a useful marker in detecting graft rejection and cytomegalovirus infection in kidney transplant recipients 3,19–29 . In contrast, the information about interrelation between neopterin and glomerulonephritis has been very limited 30–32 . Godai et al 10 reported that urinary neopterin was a valuable marker for the differential diagnosis of membranous nephropathy associated with hepatitis B surface antigenemia and yet to serve as a prognostic indicator.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of neopterin levels in patients undergoing hemodialysis

Aşçı

Baydar

Çetinkaya

et al. 2010

Hemodialysis International

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Neopterin is a diagnostic or a prognostic biomarker for several pathologies including renal diseases. However, the association between neopterin status and causative main reasons such as diabetes and hypertension for renal disease remains unclear. The aim of the study was to evaluate neopterin levels in diabetes and hypertension patients treated with/without hemodialysis. According to primary renal disorders, the patients undergoing hemodialysis were classified into 4 groups as diabetic nephropathy, hypertensive nephropathy, reflux nephropathy or interstitial nephritis, and others. The controls consisted of healthy subjects, hypertensive subjects, and diabetic individuals without any renal disorder. In the study, both urinary and serum neopterin levels were measured using high performance liquid chromatography and enzyme-linked immunosorbant assay in patients undergoing regular hemodialysis therapy (n=71). The effects of the duration of hemodialysis and treatment of erythropoietin and/or iron on neopterin levels were also evaluated. Neopterin levels were found to be higher in hemodialysis patients than in the healthy controls (P<0.05). A significant difference in neopterin levels was also found between diabetic control patients and diabetic nephropathy patients (P<0.05). A similar significant difference was detected in neopterin levels between hypertensive patients with/without nephropathy (P<0.05). Neopterin may be an early critical marker for progression of nephropathy in diabetic and hypertensive patients in early stages.

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Urinary Neopterin as a New Biochemical Marker for the Monitoring of Disease Activity and Prognosis in Membranous Nephropathy Associated with Hepatitis B Surface Antigenemia

Cited by 10 publications

References 10 publications

The Clinical Significance of Serum and Urinary Neopterin Levels in Several Renal Diseases

The Clinical Significance of Serum and Urinary Neopterin Levels in Several Renal Diseases

Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease

Evaluation of neopterin levels in patients undergoing hemodialysis

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