Urinary Microbial and Metabolomic Profiles in Kidney Stone Disease

Guo, Hong; Lin, Jinxiu; Fu, Xiong; Yu, Zuhu; Su, Pan; Huang, Yuxin

doi:10.3389/fcimb.2022.953392

Cited by 15 publications

(18 citation statements)

References 41 publications

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“…In parallel to the protective metabolites, several lines of evidence suggest that a number of amino acid metabolic pathways are closely related to the formation of kidney stone [4,[32][33][34]. Correspondingly, our research results manifest that serum cysteine is stimulative factors towards urolithiasis.…”

Section: Discussionsupporting

confidence: 67%

Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites

Hu,

Pan,

Deng

et al. 2023

Preprint

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Urolithiasis is a highly prevalent global disease closely related to metabolic factors, but we have little understanding of its underlying mechanisms. Analysis of blood metabolites may enable better comprehension of the underlying biological pathogenesis. The emergence of genome-wide association studies (GWAS) can provide an opportunity to reveal the relationship between urolithiasis and human blood metabolites through Mendelian randomization (MR). In our study, we used a two-sample MR analysis to investigate the causal relationships between urolithiasis and metabolites. The random-effects inverse-variance weighted (IVW) estimation method was used as the major method with several other estimators as supplementary methods. According to our results, we identified 11 known (5 protective and 6 risk) serum metabolites associated with urolithiasis. Among the known protective metabolites, two were lipids (3-hydroxybutyrate (BHBA) and dehydroisoandrosterone sulfate), one amino acid (Isobutyrylcarnitine), one carbohydrate (mannose), and one cofactors and vitamins (Bilirubin (Z, Z)). The known risk metabolites included two lipids (glycerol and cortisone), one amino acid (cysteine), one carbohydrate (erythronate), one peptide (pro-hydroxy-pro) and one fatty acid (eicosenoate (20:1n9 or 11)). Additionally, six metabolic pathways have been identified to be associated with urolithiasis. The evidence of human blood metabolites influencing urolithiasis provided by our results supports future efforts to improve based metabolites therapies to prevent onset of urolithiasis.

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Section: Discussionsupporting

confidence: 67%

Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites

Hu,

Pan,

Deng

et al. 2023

Preprint

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“…stones [39]. Regular monitoring of urinary parameters, including urine pH, calcium, and oxalate levels, can help identify at-risk individuals and enable early intervention.…”

Section: Plos Onementioning

confidence: 99%

Risk relationship between inflammatory bowel disease and urolithiasis: A two-sample Mendelian randomization study

Fu,

Zhu,

Chen

et al. 2024

PLoS ONE

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Background The causal genetic relationship between common parenteral manifestations of inflammatory bowel disease (IBD) and urolithiasis remains unclear because their timing is difficult to determine. This study investigated the causal genetic association between IBD and urolithiasis using Mendelian randomization (MR) based on data from large population-based genome-wide association studies (GWASs). Methods A two-sample MR analysis was performed to assess the potential relationship between IBD and urolithiasis. Specific single nucleotide polymorphism data were obtained from GWASs, including IBD (n = 59957) and its main subtypes, Crohn’s disease (CD) (n = 40266) and ulcerative colitis (UC) (n = 45975). Summarized data on urolithiasis (n = 218792) were obtained from different GWAS studies. A random-effects model was analyzed using inverse-variance weighting, MR-Egger, and weighted medians. Results Genetic predisposition to IBD and the risk of urolithiasis were significantly associated [odds ratio (OR), 1.04 (95% confidence interval [CI], 1.00–.08), P = 0.01]. Consistently, the weighted median method yielded similar results [OR, 1.06 (95% CI, 1.00–1.12), P = 0.02]. The MR-Egger method also demonstrated comparable findings [OR, 1.02 (95% CI, 0.96–1.08), P = 0.45]. Both funnel plots and MR-Egger intercepts indicated no directional pleiotropic effects between IBD and urolithiasis. CD was strongly associated with it in its subtype analysis [OR, 1.04 (95% CI, 1.01–1.07), P = 0.01], and UC was also causally associated with urolithiasis, although the association was not significant [OR, 0.99 (95% CI, 0.95–1.03), P = 0.71]. Conclusion A unidirectional positive causal correlation was identified between IBD and urolithiasis, with varying degrees of association observed among the different subtypes of IBD. Recognizing the increased incidence of urolithiasis in patients with IBD is crucial in clinical practice. Early detection and surveillance of IBD, improved patient awareness, adoption of preventive strategies, and promotion of collaborative efforts among healthcare providers regarding treatment methodologies are vital for improving patient outcomes.

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“…Gao et al. proposed that E. coli, Staphylococcus , and Lactobacillus were strong predictors of renal calculi and first reported that Mycoplasma and Micrococcus were also involved in kidney stones, but their potential significance in kidney stones still needs to be studied in more detail ( 156 ).…”

Section: Other Metabolic Changesmentioning

confidence: 99%

Metabolic changes in kidney stone disease

Yao

Duan

et al. 2023

Front. Immunol.

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Kidney stone disease (KSD) is one of the earliest medical diseases known, but the mechanism of its formation and metabolic changes remain unclear. The formation of kidney stones is a extensive and complicated process, which is regulated by metabolic changes in various substances. In this manuscript, we summarized the progress of research on metabolic changes in kidney stone disease and discuss the valuable role of some new potential targets. We reviewed the influence of metabolism of some common substances on stone formation, such as the regulation of oxalate, the release of reactive oxygen species (ROS), macrophage polarization, the levels of hormones, and the alternation of other substances. New insights into changes in substance metabolism changes in kidney stone disease, as well as emerging research techniques, will provide new directions in the treatment of stones. Reviewing the great progress that has been made in this field will help to improve the understanding by urologists, nephrologists, and health care providers of the metabolic changes in kidney stone disease, and contribute to explore new metabolic targets for clinical therapy.

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Urinary Microbial and Metabolomic Profiles in Kidney Stone Disease

Cited by 15 publications

References 41 publications

Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites

Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites

Risk relationship between inflammatory bowel disease and urolithiasis: A two-sample Mendelian randomization study

Metabolic changes in kidney stone disease

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