Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers

Jeong, Hyeon Cheol; Park, Jung Eun; Seo, Yo-Han; Kim, Min‐Gul; Shin, Kyung‐Jae

doi:10.3390/pharmaceutics13040522

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…In addition to opium alkaloids, other molecules Table 4 BLAST matching Scientific name (species) and GenBank accession codes of the nucleotide sequences that highly matched with the matK and rbcL genes of ancient samples. In all cases the percentage of query coverage was 100%, the percentage of identity was 100% for Olea europaea and 98.44% for Papaver sp., while the E value (significance of the result, max value is 0.0) was 4e −27 for matK and 1e (Imenshahidi and Hosseinzadeh 2019;Al-Snafi 2020;Jeong et al 2021). However, even in forensic science, reticuline is considered to be a marker of opium use (Al-Amri et al 2004).…”

Section: Potterymentioning

confidence: 87%

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

D’Agostino

Marco

Rolfo

et al. 2023

Veget Hist Archaeobot

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At the site of Grotta Mora Cavorso (Lazio, Italy), an unusual archaeological find, made of two coarse pottery vessels, was recovered from burial levels radiocarbon dated to 6,405–6,275 bp. These artefacts were analysed using several methods, for interpretation of the cultural practices of the earliest inhabitants in central Italy. This first molecular evidence about the potential processing and storage of poppy-based products in Neolithic pottery was obtained by detecting ancient DNA (aDNA) and chemical compounds. This study represents the second evidence from the Mediterranean area of the use of Papaver L. (poppies), although the actual use(s) of these plants then, for example as sedatives, drugs, or food, remains uncertain. Also, the employment of Olea europaea L. (olive) derivatives in foods or for other purposes was suggested, in agreement with the recovery of fruit stones at the site. The results of the present archaeobotanical investigation show the environmental knowledge of the first prehistoric communities living in central Italy, who might have shared their ethnobotanical practices.

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Section: Potterymentioning

confidence: 87%

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

D’Agostino

Marco

Rolfo

et al. 2023

Veget Hist Archaeobot

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“…We screened six common metabolites in serum and rumen fluid of lactating cattle, including D-(-)-fructose, salicylic acid, 2,3-dinor prostaglandin E1, PC (26:1/26:1), corchorifatty acid F, and suberic acid. Suberic acid, azelaic acid, and pimelic acids are involved in lipid transport and metabolism, fatty acid metabolism, and lipid peroxidation, respectively ( 45 ). This indicated that fatty acid peroxidation disorders occur in both heifers and lactating cows.…”

Section: Discussionmentioning

confidence: 99%

Altered rumen microbiome and correlations of the metabolome in heat-stressed dairy cows at different growth stages

Feng,

Zhang,

Liu

et al. 2023

Microbiol Spectr

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Heat stress is one of the major stressors affecting dairy cow production, which causes great losses in animal husbandry production and economic development. This study combined 16S rDNA sequencing, metagenomic sequencing, and metabolomic analysis to investigate the effects of heat stress on the rumen microbiome and metabolism of cows. To achieve this, 10 cows each of growing heifers, heifers, and lactating cows were selected for sample collection in April and August (a total of 60 cows). Ruminal fluid was collected, filtered through gauze, and immediately transferred to liquid nitrogen prior to metagenomic, 16S rDNA sequencing, and metabolomic analyses. Heat stress increased the abundance of pathogenic bacteria, such as Treponema_2 , Sphingobacterium , and Streptococcus , in cattle at all growth stages, with the structure and composition of rumen microbial communities being the most affected by heat stress in growing heifers and the least affected by heat stress in lactating cows. Heat stress led to a significant decrease in carbohydrate metabolic function in growing heifers and heifers, whereas microbial function was the most stable in lactating cows, suggesting that changes in microbial function are not only more conserved than microbial composition but are also affected by age. Heat stress led to significant enrichment of fatty acyl metabolites in growing heifers, heifers, and lactating cows, and the heat stress indicator species Bacillus , Lactococcus , Streptococcus , and Enterococcus were significantly associated with fatty acyl compounds in growing heifers and heifers. Therefore, heat stress alters the metabolic status of cows by modulating fatty acid biosynthesis, the PPAR signaling pathway, and arachidonic acid metabolism through the regulation of long-chain fatty acids and other biomarkers in cows at three growth stages. IMPORTANCE Heat stress is one of the main causes of economic losses in the dairy industry worldwide; however, the mechanisms associated with the metabolic and microbial changes in heat stress remain unclear. Here, we characterized both the changes in metabolites, rumen microbial communities, and their functional potential indices derived from rumen fluid and serum samples from cows at different growth stages and under different climates. This study highlights that the rumen microbe may be involved in the regulation of lipid metabolism by modulating the fatty acyl metabolites. Under heat stress, the changes in the metabolic status of growing heifers, heifers, and lactating cows were closely related to arachidonic acid metabolism, fatty acid biosynthesis, and energy metabolism. Moreover, this study provides new markers for further research to understand the effects of heat stress on the physiological metabolism of Holstein cows and the time-dependent changes associated with growth stages.

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Pharmacometabolomics: A New Horizon in Personalized Medicine

Emwas¹,

Szczepski

McKay³

et al. 2021

Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences

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Pharmacology is the predominant first-line treatment for most pathologies. However, various factors, such as genetics, gender, diet, and health status, significantly influence the efficacy of drugs in different patients, sometimes with fatal consequences. Personalized diagnosis substantially improves treatment efficacy but requires a more comprehensive process for health assessment. Pharmacometabolomics combines metabolomic, genomic, transcriptomic and proteomic approaches and therefore offers data that other analytical methods cannot provide. In this way, pharmacometabolomics more accurately guides medical professionals in predicting an individual’s response to selected drugs. In this chapter, we discuss the potentials and the advantages of metabolomics approaches for designing innovative and personalized drug treatments.

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Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers

Cited by 3 publications

References 34 publications

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

Altered rumen microbiome and correlations of the metabolome in heat-stressed dairy cows at different growth stages

Pharmacometabolomics: A New Horizon in Personalized Medicine

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