Urinary metabolome identifies signatures of oligozoospermic infertile men

Zhang, Jie; Huang, Zhenzhen; Chen, Minjian; Xia, Yankai; Martin, Francis L.; Hang, Wei; Shen, Heqing

doi:10.1016/j.fertnstert.2014.03.033

Cited by 53 publications

(31 citation statements)

References 49 publications

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“…Bioinformatics increases the value of metabolomic analysis by assessing general biochemical and signaling pathways that may be altered in disease states [15]. To date, few metabolomics studies for human male factor infertility have been reported [16][17][18][19]. Therefore, we performed an NMR metabolomic analysis of human seminal plasma from normal fertile controls and men with oligospermic infertility.…”

Section: Introductionmentioning

confidence: 99%

Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans

et al. 2020

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Infertility affects 12–15% of couples worldwide, and male factors are the cause of nearly half of all cases. Studying seminal fluid composition could lead to additional diagnostic accuracy and a better understanding of the pathophysiology of male factor infertility. Metabolomics offers a new opportunity to evaluate biomarkers and better understand pathological mechanisms. The aim of the study was to identify new markers or therapeutic targets to improve outcomes in male factor or idiopathic infertility patients. Semen samples were obtained from 29 men with a normal spermogram test, and from 18 oligozoospermic men. Samples were processed and analyzed by Nuclear Magnetic Resonance spectroscopy and, subsequently, multivariate and univariate statistical analyses. Receiving Operator Curves (ROC) and Spearman correlations were also performed. An Orthogonal Partial Least Square Discriminant Analysis supervised multivariate model was devised to compare the groups. The levels of fructose, myo-inositol, aspartate and choline were altered. Moreover, Spearman Correlation associated fructose, aspartate and myo-inositol with the total amount of spermatozoa, total motile spermatozoa, % of immotility and % of “in situ” spermatozoic motility respectively. NMR-based metabolomics allowed the identification of a specific metabolic fingerprint of the seminal fluids of patients affected by oligozoospermia.

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Section: Introductionmentioning

confidence: 99%

Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans

et al. 2020

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“…Oligozoospermic infertile men showed altered urinary metabolic profiles compared with the fertile control population, and this differentiation indicates that oligozoospermia may have resulted from energy and antioxidative perturbations in spermatogenesis [7]. Serum metabolic analysis revealed different metabolic activity patterns in a group of uncontrolled subjects with different sperm concentrations and identified protein complement C3f as a potential biomarker [5].…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Profiling Identifies Characterization of Non-Obstructive Azoospermic Men

Zhang

Liu

et al. 2017

IJMS

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Male infertility is considered a common health problem, and non-obstructive azoospermia with unclear pathogenesis is one of the most challenging tasks for clinicians. The objective of this study was to investigate the differential serum metabolic pattern in non-obstructive azoospermic men and to determine potential biomarkers related to spermatogenic dysfunction. Serum samples from patients with non-obstructive azoospermia (n = 22) and healthy controls (n = 31) were examined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Serum metabolomic profiling could differentiate non-obstructive azoospermic patients from healthy control subjects. A total of 24 metabolites were screened and identified as potential markers, many of which are involved in energy production, oxidative stress and cell apoptosis in spermatogenesis. Moreover, the results showed that various metabolic pathways, including d-glutamine and d-glutamate metabolism, taurine and hypotaurine metabolism, pyruvate metabolism, the citrate cycle and alanine, aspartate and glutamate metabolism, were disrupted in patients with non-obstructive azoospermia. Our results indicated that the serum metabolic disorders may contribute to the etiology of non-obstructive azoospermia. This study suggested that serum metabolomics could identify unique metabolic patterns of non-obstructive azoospermia and provide novel insights into the pathogenesis underlying male infertility.

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“…Whether expulsion is higher or lower in adolescents using the LNG20 versus LNG14 IUD is unknown, as women younger than 18 were excluded from comparative trials [32, 35]. A multicenter, single-arm study of the LNG14 IUD in adolescents found one-year expulsion rate of 3.3% [36]. Amenorrhea occurs in 13% of adult women with the LNG14 IUD compared to 24% of the women with the LNG20 IUD after three years [35].…”

Section: Long Acting Reversible Contraceptive (Larc) Methodsmentioning

confidence: 99%

Contraception for Adolescents: Focusing on Long-Acting Reversible Contraceptives (LARC) to Improve Reproductive Health Outcomes

Kaneshiro

Salcedo

2015

Curr Obstet Gynecol Rep

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Adolescent pregnancy rates in the U.S. have reached an all-time low from their peak in the 1980s and 1990s. However, the U.S. maintains the highest rate of teenage pregnancy among developed nations. Adolescents experience higher typical use failure rates for user-dependent contraceptives compared to their adult counterparts. Long-acting reversible contraception (LARC), IUDs and implants, have failure rates that are both very low and independent of user age. In settings where the most effective methods are prioritized and access barriers are removed, the majority of adolescents initiate LARC. Use of LARC by adolescents significantly reduces rates of overall and repeat teen pregnancy. All methods of contraception are safe for use in teens, including IUDs and DMPA. Dual use of LARC and barrier methods to reduce risk of sexually transmitted infection, is the optimal contraceptive strategy for most adolescents. Adolescent access to evidence-based and confidential contraceptive services, provided in a manner that respects autonomy, is a vital public health goal.

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Urinary metabolome identifies signatures of oligozoospermic infertile men

Cited by 53 publications

References 49 publications

Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans

Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans

Serum Metabolomic Profiling Identifies Characterization of Non-Obstructive Azoospermic Men

Contraception for Adolescents: Focusing on Long-Acting Reversible Contraceptives (LARC) to Improve Reproductive Health Outcomes

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