2009
DOI: 10.1093/humrep/dep006
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Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility

Abstract: Increased urinary concentrations of 1-OHP, 2-OHF and Sum PAH metabolites were associated with increased male idiopathic infertility risks, while the idiopathic infertile subjects with abnormal semen might be at higher risk.

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Cited by 77 publications
(55 citation statements)
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“…Higher idiopathic infertility risk was found in the group of idiopathic infertile subjects with the abnormal semen quality [26]. In the next study by the same authors i.e.…”
Section: Discussionmentioning
confidence: 66%
See 1 more Smart Citation
“…Higher idiopathic infertility risk was found in the group of idiopathic infertile subjects with the abnormal semen quality [26]. In the next study by the same authors i.e.…”
Section: Discussionmentioning
confidence: 66%
“…Another study found that the presence of PAH-DNA adducts in sperm is associated with abnormal morphology [25]. [26] report that exposure to PAHs at environmental levels is associated with an increased risk of male IJOMEH 2013;26(5) 792 stained according to Papanicolaou [31]. A total of 200 sperm samples were analyzed.…”
Section: Introductionmentioning
confidence: 99%
“…In general, PAHs are present in fossil fuels (oil and coal), tar deposits and overcooked food and are generated when incomplete combustion of organic material occurs. Exposure to these compounds has been correlated with a higher risk of infertility as men with idiopathic infertility and abnormal sperm parameters were shown to have increased levels of urinary PAH metabolites when compared to controls (Xia et al 2009). Furthermore, non-genomic studies ( Table 1) have shown that although modest effects on human sperm motility were observed after immediate Endocrine disruptors and mature spermatozoa exposure to diesel particulate extracts, a marked alteration in all CASA parameters reflecting sperm movement and hyperactivation (motility, curvilinear velocity, straight line velocity, linearity, and amplitude of lateral head displacement) was elicited upon 18 h of exposure (Fredricsson et al 1993).…”
Section: Polycyclic Aromatic Hydrocarbonsmentioning
confidence: 99%
“…Besides being detected in urine (Jonsson et al 2005, Xia et al 2009, Jurewicz et al 2013, breast milk (Chikuni et al 1991, Mocarelli et al 2011, and blood serum (Younglai et al 2002, Mocarelli et al 2008, important amounts of EDCs have also been found in secretions of the female reproductive tract, cervical mucus and follicular and seminal fluids (Tsutsumi et al 1998, Younglai et al 2002, Drbohlav et al 2005. This is particularly relevant as spermatozoa steep in these reproductive fluids/secretions on their journey toward the oocyte and are therefore in direct contact with such toxicants, an important route of exposure that should not be neglected.…”
Section: Introductionmentioning
confidence: 99%
“…The urine 1-hydroxypyrene, as a sensitive PAH-exposure biomarker, was determined as previously described (32). The analytes were hydrolyzed with use of b-glucuronidase/arylsulfatase (98%; Sigma-Aldrich, St. Louis, MO) and were separated from the matrix by solid-phase extraction.…”
Section: Analysis Of Exposure To Pahsmentioning
confidence: 99%