Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility

Xia, Yankai; Zhu, Pengfei; Yan, Han; Lu, Chuncheng; Wang, Shoulin; Gu, Aihua; Fu, Guangbo; Zhao, Rongsheng; Lee, Song; Wang, Xinru

doi:10.1093/humrep/dep006

Cited by 76 publications

(49 citation statements)

References 47 publications

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“…Higher idiopathic infertility risk was found in the group of idiopathic infertile subjects with the abnormal semen quality [26]. In the next study by the same authors i.e.…”

Section: Discussionmentioning

confidence: 66%

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Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Growing evidence supports the reproductive and developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) from prenatal and postnatal exposure, but the results of epidemiological studies regarding harmful effects of PAHs exposure on male reproductive system still remain limited and inconclusive. The aim of the present study was to investigate the relationship between 1-hydroxypyrene, a biomarker of polycyclic aromatic hydrocarbons exposure and semen quality. Materials and Methods:The study population consisted of 277 men attending an infertility clinic for diagnostic purposes and having normal semen concentration of 20-300 mln/ml or slight oligozoospermia (semen concentration: 15-20 mln/ml) (WHO 1999). All the men were healthy and under 45 years of age. All participants were interviewed and provided a semen sample. The interview included questions concerning demographics, socio-economic status, medical history related to past diseases which may have an impact on semen quality, lifestyle factors and occupational information. Concentrations of 1-hydroxypyrene (1-OHP) in the urine samples were analyzed using high performance liquid chromatography (HPLC). Results: A positive association was found between the level of 1-OHP in urine and sperm neck abnormalities as well as the percentage of static sperm cells (p = 0.001, p = 0.018, respectively). Additionally, exposure to PAHs measured by 1-OHP in urine decreased semen volume and the percentage of motile sperm cells (p = 0.014, p = 0.0001, respectively). Conclusions: Presented findings indicate that the environmental level of PAHs exposure adversely affects male semen quality. The future large-scale studies should incorporate different biomarkers to generate a more accurate and full assessment of the effects of PAHs exposure on male fertility.

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“…Higher idiopathic infertility risk was found in the group of idiopathic infertile subjects with the abnormal semen quality [26]. In the next study by the same authors i.e.…”

Section: Discussionmentioning

confidence: 66%

“…Another study found that the presence of PAH-DNA adducts in sperm is associated with abnormal morphology [25]. [26] report that exposure to PAHs at environmental levels is associated with an increased risk of male IJOMEH 2013;26(5) 792 stained according to Papanicolaou [31]. A total of 200 sperm samples were analyzed.…”

Section: Introductionmentioning

confidence: 99%

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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show abstract

“…In general, PAHs are present in fossil fuels (oil and coal), tar deposits and overcooked food and are generated when incomplete combustion of organic material occurs. Exposure to these compounds has been correlated with a higher risk of infertility as men with idiopathic infertility and abnormal sperm parameters were shown to have increased levels of urinary PAH metabolites when compared to controls (Xia et al 2009). Furthermore, non-genomic studies ( Table 1) have shown that although modest effects on human sperm motility were observed after immediate Endocrine disruptors and mature spermatozoa exposure to diesel particulate extracts, a marked alteration in all CASA parameters reflecting sperm movement and hyperactivation (motility, curvilinear velocity, straight line velocity, linearity, and amplitude of lateral head displacement) was elicited upon 18 h of exposure (Fredricsson et al 1993).…”

Section: Polycyclic Aromatic Hydrocarbonsmentioning

confidence: 99%

“…Besides being detected in urine (Jonsson et al 2005, Xia et al 2009, Jurewicz et al 2013, breast milk (Chikuni et al 1991, Mocarelli et al 2011, and blood serum (Younglai et al 2002, Mocarelli et al 2008, important amounts of EDCs have also been found in secretions of the female reproductive tract, cervical mucus and follicular and seminal fluids (Tsutsumi et al 1998, Younglai et al 2002, Drbohlav et al 2005. This is particularly relevant as spermatozoa steep in these reproductive fluids/secretions on their journey toward the oocyte and are therefore in direct contact with such toxicants, an important route of exposure that should not be neglected.…”

Section: Introductionmentioning

confidence: 99%

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Tavares

Escada-Rebelo

Correia³

et al. 2016

Reproduction

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Exposure to toxicants present in the environment, especially the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in male reproductive organs over the past decades. Both human and animal populations are continuously exposed to ubiquitous synthetic and natural-occurring EDCs through diet, dermal contact and/or inhalation, therefore potentially compromising male reproductive health. Although the effects of EDC are likely induced via multiple genomic-based pathways, their non-genomic effects may also be relevant. Furthermore, spermatozoa are transcriptionally inactive cells that can come in direct contact with EDCs in reproductive fluids and secretions and are therefore a good model to address non-genomic effects. This review thus focuses on the non-genomic effects of several important EDCs relevant to mammalian exposure. Notably, EDCs were found to interfere with pre-existing pathways inducing a panoply of deleterious effects to sperm function that included altered intracellular Ca 2C oscillations, induction of oxidative stress, mitochondrial dysfunction, increased DNA damage and decreased sperm motility and viability, among others, potentially jeopardizing male fertility. Although many studies have used non-environmentally relevant concentrations of only one compound for mechanistic studies, it is important to remember that mammals are not exposed to one, but rather to a multitude of environmental EDCs, and synergistic effects may occur. Furthermore, some effects have been detected with single compounds at environmentally relevant concentrations.Reproduction (2016) 151 R1-R13

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“…The urine 1-hydroxypyrene, as a sensitive PAH-exposure biomarker, was determined as previously described (32). The analytes were hydrolyzed with use of b-glucuronidase/arylsulfatase (98%; Sigma-Aldrich, St. Louis, MO) and were separated from the matrix by solid-phase extraction.…”

Section: Analysis Of Exposure To Pahsmentioning

confidence: 99%

Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility

Zhu

et al. 2010

Fertility and Sterility

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Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility

Abstract: Increased urinary concentrations of 1-OHP, 2-OHF and Sum PAH metabolites were associated with increased male idiopathic infertility risks, while the idiopathic infertile subjects with abnormal semen might be at higher risk.

Cited by 76 publications

References 47 publications

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility

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