Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers

Qian, Xi; Wan, Yanjian; Wang, Aizhen; Xia, Wei; Zong, Yang; He, Zhen-Yu; Xu, Shunqing

doi:10.1016/j.envpol.2021.117913

Cited by 36 publications

(21 citation statements)

References 56 publications

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“…Therefore, MHBMA3 detected in human urine should be one of the two stereoisomers rather than the mixture of the two stereoisomers. It has not been clear whether the difference in the frequency of detection of MHBMA3 between the studies of Qian et al or Kuang et al [ 152 , 153 ] and those reported by other authors [ 44 , 63 , 64 , 139 – 148 , 151 ] is caused by the configuration of the biomarker.…”

Section: Introductionmentioning

confidence: 95%

“…Chiang et al reported that the mean MHBMA3 concentrations in 55 Taiwanese smokers and 55 non-smokers were 129.2 ± 99.2 and 52.3 ± 36.8 ng/mL, respectively [ 140 ], which were considerably higher than that reported by Alwis et al, in particular, the concentrations in non-smokers. A recently published study on the general population in Wuhan, China, reported a surprisingly low frequency of detection at only 9.4% [ 152 ]. Similarly, another study performed in China even failed to detect MHBMA3 in 100 urine samples from children aged 6-12 years [ 153 ].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, another study performed in China even failed to detect MHBMA3 in 100 urine samples from children aged 6-12 years [ 153 ]. A possible explanation for the surprising observations reported in the two studies is that the authors used cis -MHBMA3 as the reference standard and the LOD in the latter study was somewhat high (3.13 ng/mL) [ 152 , 153 ], although in the studies of Alwis et al [ 139 ] and other authors [ 44 , 63 , 64 , 140 – 148 , 151 ], the configuration of the MHBMA3 standard was not specified.…”

Section: Introductionmentioning

confidence: 99%

“…A major issue concerning MHBMA3 is that its configuration is not specified in all studies except for two recent ones [ 152 , 153 ]. This compound has two configurations or two stereoisomers, i.e., trans - and cis -MHBMA3 (Fig.…”

Section: Introductionmentioning

confidence: 99%

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1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases

Chen

Zhang

2022

Genes and Environ

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Abstract1,3-Butadiene (BD) is a petrochemical manufactured in high volumes. It is a human carcinogen and can induce lymphohematopoietic cancers, particularly leukemia, in occupationally-exposed workers. BD is an air pollutant with the major environmental sources being automobile exhaust and tobacco smoke. It is one of the major constituents and is considered the most carcinogenic compound in cigarette smoke. The BD concentrations in urban areas usually vary between 0.01 and 3.3 μg/m3 but can be significantly higher in some microenvironments. For BD exposure of the general population, microenvironments, particularly indoor microenvironments, are the primary determinant and environmental tobacco smoke is the main contributor. BD has high cancer risk and has been ranked the second or the third in the environmental pollutants monitored in most urban areas, with the cancer risks exceeding 10-5. Mutagenicity/carcinogenicity of BD is mediated by its genotoxic metabolites but the specific metabolite(s) responsible for the effects in humans have not been determined. BD can be bioactivated to yield three mutagenic epoxide metabolites by cytochrome P450 enzymes, or potentially be biotransformed into a mutagenic chlorohydrin by myeloperoxidase, a peroxidase almost specifically present in neutrophils and monocytes. Several urinary BD biomarkers have been developed, among which N-acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine is the most sensitive and is suitable for biomonitoring BD exposure in the general population. Exposure to BD has been associated with leukemia, cardiovascular disease, and possibly reproductive effects, and may be associated with several cancers, autism, and asthma in children. Collectively, BD is a ubiquitous pollutant that has been associated with a range of adverse health effects and diseases with children being a subpopulation with potentially greater susceptibility. Its adverse effects on human health may have been underestimated and more studies are needed.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases

Chen

Zhang

2022

Genes and Environ

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“…The special effects of these compounds include their role in reducing stratospheric ozone, global warming, and toxic and carcinogenic effects on human health [ 16 , 17 ]. So far, many studies have been performed to measure VOCs in the air or their urinary metabolites [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Palladium-Doped Single-Walled Carbon Nanotubes as a New Adsorbent for Detecting and Trapping Volatile Organic Compounds: A First Principle Study

2022

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Volatile organic compounds (VOCs) are in the vapor state in the atmosphere and are considered pollutants. Density functional theory (DFT) calculations with the wb97xd exchange correlation functional and the 6-311+G(d,p) basis set are carried out to explore the potential possibility of palladium-doped single-walled carbon nanotubes (Pd/SWCNT-V), serving as the resource for detecting and/or adsorbing acetonitrile (ACN), styrene (STY), and perchloroethylene (PCE) molecules as VOCs. The suggested adsorbent in this study is discussed with structural parameters, frontier molecular orbital theory, molecular electrical potential surfaces (MEPSs), natural bond orbital (NBO) analyses, and the density of states. Furthermore, following the Bader theory of atoms in molecules (AIM), the topological properties of the electron density contributions for intermolecular interactions are analyzed. The obtained results show efficient VOC loading via a strong chemisorption process with a mean adsorption energy of −0.94, −1.27, and −0.54 eV for ACN, STY, and PCE, respectively. Our results show that the Pd/SWCNT-V can be considered a good candidate for VOC removal from the environment.

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A new methodology to reveal potential nucleic acid modifications associated with the risk of endometrial cancer through dispersive solid-phase extraction coupled with UHPLC-QE-Orbitrap-MS/MS and HPLC–UV

Zhao,

Zhang,

Zuo

et al. 2024

Anal Bioanal Chem

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Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers

Cited by 36 publications

References 56 publications

1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases

1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases

Palladium-Doped Single-Walled Carbon Nanotubes as a New Adsorbent for Detecting and Trapping Volatile Organic Compounds: A First Principle Study

A new methodology to reveal potential nucleic acid modifications associated with the risk of endometrial cancer through dispersive solid-phase extraction coupled with UHPLC-QE-Orbitrap-MS/MS and HPLC–UV

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