Urinary metabolites before and after cleanup and subjective symptoms in volunteer participants in cleanup of the Hebei Spirit oil spill

Ha, Mina; Kwon, Ho-Jang; Cheong, Hae-Kwan; Lim, Sinye; Yoo, Seung Jin; Kim, Eun-Jung; Park, Seok Gun; Lee, Jeongae; Chung, Bong Chul

doi:10.1016/j.scitotenv.2012.04.036

Cited by 49 publications

(28 citation statements)

References 33 publications

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“…These reviewers have found that the majority of the studies reported a spike in acute physical and mental health symptoms following a oil spill exposure. These symptoms included headache, shortness of breath, fatigue, cough, skin rash, diarrhea, low back pain, depression, anxiety, and posttraumatic stress syndrome following the spill ( 17 – 23 ). Earlier studies have also shown that the cleanup workers and local residents had an increased prevalence of respiratory symptoms immediately after their exposure to the oil spill ( 8 , 24 , 25 ) and that these effects persisted for prolonged time periods after the spill ( 26 – 28 ).…”

Section: Introductionmentioning

confidence: 99%

The Development of Long-Term Adverse Health Effects in Oil Spill Cleanup Workers of the Deepwater Horizon Offshore Drilling Rig Disaster

D’Andrea¹,

Reddy²

2018

Front. Public Health

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BackgroundThe purpose of this study was to assess the long-term adverse health effects of the 2010 Deepwater Horizon Gulf oil spill exposure in workers who participated in its cleanup work.MethodsMedical charts of both the oil spill exposed and unexposed subjects were reviewed. The changes in the white blood cells, platelets, hemoglobin, hematocrit, blood urea nitrogen, creatinine, alkaline phosphatase (ALP), aspartate amino transferase (AST), alanine amino transferase (ALT) levels, as well as their pulmonary and cardiac functions were evaluated.ResultsMedical records from 88 subjects (oil spill cleanup workers, n = 44 and unexposed, n = 44) were reviewed during initial and 7 years follow up visits after the disaster occurred. Compared with the unexposed subjects, oil spill exposed subjects had significantly reduced platelet counts (×103/µL) at their initial (254.1 ± 46.7 versus 289.7 ± 63.7, P = 0.000) and follow-up (242.9 ± 55.6 versus 278.4 ± 67.6, P = 0.000) visits compared with the unexposed subjects (254.6 ± 51.9 versus 289.7 ± 63.7, P = 0.008). The hemoglobin and hematocrit levels were increased significantly both at their initial and follow-up visits in the oil spill exposed subjects compared to the unexposed subjects. Similarly, the oil spill exposed subjects had significantly increased ALP, AST, and ALT levels at their initial and follow-up visits compared with those of the unexposed subjects. Illness symptoms that were reported during their initial visit still persisted at their 7-year follow-up visit. Notably, at their 7-year follow-up visit, most of the oil spill exposed subjects had also developed chronic rhinosinusitis and reactive airway dysfunction syndrome as new symptoms that were not reported during their initial visit. Additionally, more abnormalities in pulmonary and cardiac functions were also seen in the oil spill exposed subjects.ConclusionThis long-term follow-up study demonstrates that those people involved in the oil spill cleanup operations experiences persistent alterations or worsening of their hematological, hepatic, pulmonary, and cardiac functions. In addition, these subjects experienced prolonged or worsening illness symptoms even 7 years after their exposure to the oil spill.

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Section: Introductionmentioning

confidence: 99%

The Development of Long-Term Adverse Health Effects in Oil Spill Cleanup Workers of the Deepwater Horizon Offshore Drilling Rig Disaster

D’Andrea¹,

Reddy²

2018

Front. Public Health

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“…obs., pers. comm., 2010; also see Suarez et al 2005;Sim et al 2010;Levy and Nassetta 2011;Ha et al 2012). They were exposed to the following contaminated environments prior to sampling: seawater, air, wetlands, or a sandy beach.…”

Section: Generalmentioning

confidence: 99%

Concentrations in human blood of petroleum hydrocarbons associated with the BP/Deepwater Horizon oil spill, Gulf of Mexico

Sammarco

Kolian²,

Warby³

et al. 2015

Arch Toxicol

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During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and had blood analyses analyzed for volatile organic compounds; samples were drawn 5-19 months after the spill had been capped. We examined the petroleum hydrocarbon concentrations in the blood. The aromatic compounds m,p-xylene, toluene, ethylbenzene, benzene, o-xylene, and styrene, and the alkanes hexane, 3-methylpentane, 2-methylpentane, and iso-octane were detected. Concentrations of the first four aromatics were not significantly different from US National Health and Nutritional Examination Survey/US National Institute of Standards and Technology 95th percentiles, indicating high concentrations of contaminants. The other two aromatics and the alkanes yielded equivocal results or significantly low concentrations. The data suggest that single-ring aromatic compounds are more persistent in the blood than alkanes and may be responsible for the observed symptoms. People should avoid exposure to crude oil through avoidance of the affected region, or utilizing hazardous materials suits if involved in cleanup, or wearing hazardous waste operations and emergency response suits if SCUBA diving. Concentrations of alkanes and PAHs in the blood of coastal residents and workers should be monitored through time well after the spill has been controlled.

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“…Studies on potential health effects of Hebei Spirit oil spill were mostly on immediate or acute health effects which included physical and mental symptoms (Cheong et al, 2011;Ha et al, 2012;Lee et al, 2010;Sim et al, 2010). Acute symptoms such as eye symptoms, headaches, skin symptoms, neurovestibular symptoms and respiratory symptoms, persisted for more than 1 to 2 years after one large oil spill accident (Na et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress biomarkers in long-term participants in clean-up work after the Hebei Spirit oil spill

Noh

Cheong

et al. 2015

Science of The Total Environment

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Urinary metabolites before and after cleanup and subjective symptoms in volunteer participants in cleanup of the Hebei Spirit oil spill

Cited by 49 publications

References 33 publications

The Development of Long-Term Adverse Health Effects in Oil Spill Cleanup Workers of the Deepwater Horizon Offshore Drilling Rig Disaster

The Development of Long-Term Adverse Health Effects in Oil Spill Cleanup Workers of the Deepwater Horizon Offshore Drilling Rig Disaster

Concentrations in human blood of petroleum hydrocarbons associated with the BP/Deepwater Horizon oil spill, Gulf of Mexico

Oxidative stress biomarkers in long-term participants in clean-up work after the Hebei Spirit oil spill

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