Urinary Mercury Levels and Predictors of Exposure among a Group of Italian Children

Astolfi, Maria Luisa; Vitali, Matteo; Marconi, Elisabetta; Martellucci, Stefano; Mattei, Vincenzo; Canepari, Silvia; Protano, Carmela

doi:10.3390/ijerph17249225

Cited by 11 publications

(3 citation statements)

References 60 publications

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“…Two different sites in central Italy were individuated for the study: a rural area, at low population and traffic density, and an urban area, at medium population and traffic density [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Exposure Profile to Traffic Related Pollution in Pediatric Age: A Biomonitoring Study

Antonucci

Protano

Astolfi

et al. 2021

IJERPH

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The aim of this study was to trace an exposure profile to traffic-derived pollution during pediatric age. For this purpose, two biomonitoring campaigns for the determination of urinary (u-) methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE), tert-amyl methyl ether (TAME), and diisopropyl ether (DIPE) were carried out in two different periods of the year (summer 2017 and winter 2018), among a large sample of healthy children (n = 736; 5–11 years old) living in rural and urban areas in central Italy. The quantification of u-MTBE, u-ETBE, u-TAME, and u-DIPE was performed by HS-SPME-GC/MS technique and information on participants was collected by a questionnaire. u-DIPE concentrations resulted always under the LOQ. u-TAME mean levels were similar in both seasons (18.7 ng L−1 in summer vs. 18.9 ng L−1 in winter), while u-MTBE and u-ETBE levels were, respectively, 69.9 and 423.5 ng L−1 (summer) and 53.3 and 66.2 ng L−1 (winter). Main predictors of urinary excretion resulted the time spent in motor vehicles, being male and younger.

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Section: Methodsmentioning

confidence: 99%

Exposure Profile to Traffic Related Pollution in Pediatric Age: A Biomonitoring Study

Antonucci

Protano

Astolfi

et al. 2021

IJERPH

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“…Urinary elements were analyzed by ICP-MS (820-MS; Bruker, Bremen, Germany) equipped with a collision reaction interface (CRI) for Ba, Be, Bi, Cd, Cs, Cu, Fe, Ni, Pb, Rb, Sb, Se, Sr, Te, and V and by CV-AFS (AFS 8220 Titan, FullTech Instruments, Rome, Italy) for Hg, as described previously, with minor modifications [20][21][22]. The parameters and operating conditions of ICP-MS are detailed elsewhere [23].…”

Section: Analytical Determination Of Urinary Elementsmentioning

confidence: 99%

Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals

Buonaurio

Astolfi

Pigini

et al. 2021

Cancers

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Urinary concentrations of 16 different exposure biomarkers to metals were determined at the beginning and at the end of a working shift on a group of workers in the metal carpentry industry. Five different oxidative stress biomarkers were also measured, such as the oxidation products of RNA and DNA metabolized and excreted in the urine. The results of workers exposed to metals were compared to those of a control group. The metal concentrations found in these workers were well below the occupational exposure limit values and exceeded the mean concentrations of the same metals in the urine of the control group by a factor of four at maximum. Barium (Ba), mercury (Hg), lead (Pb) and strontium (Sr) were correlated with the RNA oxidative stress biomarker, 8-oxo-7, 8-dihydroguanosine (8-oxoGuo), which was found able to discriminate exposed workers from controls with a high level of specificity and sensitivity. The power of this early diagnostic technique was assessed by means of the ROC curve. Ba, rubidium (Rb), Sr, tellurium (Te), and vanadium (V) were correlated with the level of the protein oxidation biomarker 3-Nitrotyrosine (3-NO2Tyr), and Ba, beryllium (Be), copper (Cu), and Rb with 5-methylcytidine (5-MeCyt), an epigenetic marker of RNA damage. These effect biomarkers can help in identifying those workers that can be defined as “occupationally exposed” even at low exposure levels, and they can provide information about the impact that such doses have on their health.

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“…A CV-AFS (AFS 8220 Titan, FullTech Instruments, Rome, Italy) was used for Hg determination. The preparations of the calibration standards and the detailed ICP-MS and CV-AFS operating conditions were described in previous papers [ 62 , 63 , 64 ]. The limits of determination (LoDs) and quantification (LoQs) were calculated, respectively, as three and ten times σ/b, where σ is the standard deviation of blank determination (ten replicates) and b is the slope of the calibration curve.…”

Section: Methodsmentioning

confidence: 99%

Biomonitoring of Exposure to Urban Pollutants and Oxidative Stress during the COVID-19 Lockdown in Rome Residents

Buonaurio

Borra

Pigini

et al. 2022

Toxics

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Background: The objective of this study is to evaluate the effects of traffic on human health comparing biomonitoring data measured during the COVID-19 lockdown, when restrictions led to a 40% reduction in airborne benzene in Rome and a 36% reduction in road traffic, to the same parameters measured in 2021. Methods: Biomonitoring was performed on 49 volunteers, determining the urinary metabolites of the most abundant traffic pollutants, such as benzene and PAHs, and oxidative stress biomarkers by HPLC/MS-MS, 28 elements by ICP/MS and metabolic phenotypes by NMR. Results: Means of s-phenylmercaputric acid (SPMA), metabolites of naphthalene and nitropyrene in 2020 are 20% lower than in 2021, while 1-OH-pyrene was 30% lower. A reduction of 40% for 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodGuo) and 60% for 8-oxo-7,8-dihydroguanine (8-oxoGua) were found in 2020 compared to 2021. The concentrations of B, Co, Cu and Sb in 2021 are significantly higher than in the 2020. NMR untargeted metabolomic analysis identified 35 urinary metabolites. Results show in 2021 a decrease in succinic acid, a product of the Krebs cycle promoting inflammation. Conclusions: Urban pollution due to traffic is partly responsible for oxidative stress of nucleic acids, but other factors also have a role, enhancing the importance of communication about a healthy lifestyle in the prevention of cancer diseases.

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Urinary Mercury Levels and Predictors of Exposure among a Group of Italian Children

Cited by 11 publications

References 60 publications

Exposure Profile to Traffic Related Pollution in Pediatric Age: A Biomonitoring Study

Exposure Profile to Traffic Related Pollution in Pediatric Age: A Biomonitoring Study

Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals

Biomonitoring of Exposure to Urban Pollutants and Oxidative Stress during the COVID-19 Lockdown in Rome Residents

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