Urinary magnesium predicts risk of cardiovascular disease in Chronic Kidney Disease stage 1–4 patients

Xie, Yanyun; Peng, Zhangzhe; Wang, Jinwei; Xiao, Xiangcheng; Wang, Wei; Huang, Ling; Tang, Wenbin; Li, Xiaozhao; Wang, Fang; Tao, Ling; He, Kevin; Wanggou, Siyi; Xu, Hui; Zhao, Ming‐Hui; Zhang, Luxia; Wang, Xiaoqin; Yuan, Jun; Zhou, Qiaoling; Yuan, Qiongjing; Chen, Menghua; Zhou, Xiaoling; S, Fu; Li, Shaomei; Zha, Yan; Huang, Rongsai; Liu, Zhangsuo; Wang, Li; Liao, Pu; Liu, Jian; Li, Suhua; Xiong, Zuying; Liang, Wei; Zhao, Jinghong; Mu, Jiao; Lian, Xin; Liao, Yunjuan; Gan, Hua; Liao, Liping; Wang, Rong; Lv, Zhimei; Liao, Yunhua; Pan, Ling; Yang, Xiaoping; Lin, Zhifeng; Tong, Zongwu; Zhu, Yun; He, Qiang; Wu, Fuquan; Li, Rong; Rong, Kai; Wang, Caili; Zhang, Yanhui; Wang, Yue; Wen, Tao; Wu, Hua; Bán, Zoltán; Li, Rongshan; Wang, Lihua; Du, Feng; Wu, Yonggui; Zhang, Wei; Lin, Shan; Xu, Pengcheng; Lin, Hongli; Zhao, Hong; Pei, Fei; Zhang, Haisong; Gao, Yan; Sun, Luying; Li, Xia; Wang, Wenke; Lv, Fengling; Wang, Deguang; Wang, Xuerong; Xu, Di; Tang, Lijun; Ma, Yingchun; Wang, Tingting; Fu, Ping; Wang, Tingli; Xing, Changying; Zhang, Chengning; Xu, Xudong; He, Hongyong; Liao, Xiaohui; Xie, Shengkun; Hu, Guicai; Huang, Lan

doi:10.1016/j.clnu.2020.10.036

Cited by 7 publications

(4 citation statements)

References 206 publications

(291 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the progressive decline of TFG in patients with CKD is associated with a significant reduction in appetite and food intake, which may impair mg intake [72,73]. In the present study, the median mg consumption was below that recommended for men and women, with no statistically significant difference between genders.…”

Section: Variablescontrasting

confidence: 63%

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Dias¹,

Brito²,

Martins³

et al. 2022

Preprint

View full text Add to dashboard Cite

(1) Background: Reduced magnesium (Mg) levels may be associated with a faster de-cline in renal function. The aim of this study was to evaluate the association of serum and uri-nary Mg levels with body composition and inflammatory markers; (2) Methods: Lon-gitudinal study with patients with chronic kidney disease undergoing non-dialysis treatment in stages 3A, 3B and 4. Venous samples were collected after a 12-hour night fast. Body composition was evaluated by Double X-Ray Emission Absorptiometry and Air Displacement Plethysmog-raphy; (3) Results: The sample consisted of 134 patients. In the adjusted linear regression model, uric acid, percentage of lean mass and ali-mentar intake of Mg were positively associated with the sergic Mg. Triglyceride levels, WC and fat mass percentage were negatively associated with serum Mg. For the Mg urinal, in the adjusted model, the eGFR (estimated glomerular filtration rate), IL (interleukin 6), food intake of Mg and the percentage of lean mass showed a positive correlation.; (4) Conclusions: Serum Mg levels were positively associated with lean mass and negatively with total and central body fat and urinary Mg was positively associated with IL6 and lean mass.

show abstract

Section: Variablescontrasting

confidence: 63%

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Dias¹,

Brito²,

Martins³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the effect of reduced urinary magnesium excretion on clinical outcomes seems to be controversial: a higher risk for CVD was observed in those with reduced urinary magnesium excretion in a general population, although plasma magnesium concentrations or dietary intake were not provided[ 32 ]. More recently, after adjusting for several potential confounders, a positive association between 24-h urinary magnesium and cardiovascular events was found in patients with CKD and normal serum magnesium levels [ 33 ]. This may be related to an impaired ability of the kidney to completely reabsorb the filtered load of magnesium in CKD.…”

Section: Discussionmentioning

confidence: 99%

Urinary metabolic profile and stone composition in kidney stone formers with and without heart disease

et al. 2021

View full text Add to dashboard Cite

Objective Kidney stone disease seems to be associated with an increased risk of incident cardiovascular outcomes; the aim of this study is to identify differences in 24-h urine excretory profiles and stone composition among stone formers with and without cardiovascular disease (CVD). Methods Data from patients attending the Department of Renal Medicine’s metabolic stone clinic from 1995 to 2012 were reviewed. The sample was divided according to the presence or absence of CVD (myocardial infarction, angina, coronary revascularization, or surgery for calcified heart valves). Univariable and multivariable regression models, adjusted for age, sex, BMI, hypertension, diabetes, eGFR, plasma bicarbonate and potential renal acid load of foods were used to investigate differences across groups. Results 1826 patients had available data for 24-h urine analysis. Among these, 108 (5.9%) had a history of CVD. Those with CVD were older, have higher prevalence of hypertension and diabetes and lower eGFR. Univariable analysis showed that patients with CVD had significantly lower 24-h urinary excretions for citrate (2.4 vs 2.6 mmol/24 h, p = 0.04), magnesium (3.9 vs 4.2 mmol/24 h, p = 0.03) and urinary pH (6.1 vs 6.2, p = 0.02). After adjustment for confounders, differences in urinary citrate and magnesium excretions remained significant. No differences in the probability of stone formation or stone compositions were found. Conclusions Stone formers with CVD have lower renal alkali excretion, possibly suggesting higher acid retention in stone formers with cardiovascular comorbidities. Randomized clinical trials including medications and a controlled diet design are needed to confirm the results presented here. Graphic abstract

show abstract

“…However, major supplementation trials with magnesium have reported inconsistent benefits and raised the potential for adverse effects from magnesium overload [ 55 ]. Increased urinary magnesium excretion leads to the development of CVD in CKD G-5 [ 56 ]. Behind the increased magnesium excretion is the elevated magnesium wasting that generates this seemingly paradoxical risk profile.…”

Section: Cardiovascular Mortality In Chronic Kidney Diseasementioning

confidence: 99%

Hypomagnesemia as a Risk Factor and Accelerator for Vascular Aging in Diabetes Mellitus and Chronic Kidney Disease

et al. 2023

View full text Add to dashboard Cite

The age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-examination of modifiable risk factors of accelerated vascular ageing in chronic kidney diseases. Attempts to modulate vascular risk with cholesterol-lowering agents have largely failed in advanced chronic kidney disease (CKD). In addition to nitrogen waste products, many pathological biochemical processes also play a role in vascular calcification in chronic kidney damage. Magnesium, a cation vital for the body, may substantially reduce cardiovascular diseases’ risk and progression. This narrative review aimed to address the relationship between hypomagnesemia and vascular calcification, which promotes further cardiovascular complications in diabetes, aging, and CKD. Articles with predefined keywords were searched for in the PubMed and Google Scholar databases with specific inclusion and exclusion criteria. We hypothesized that a decrease in serum magnesium levels contributes to increased vascular calcification and thereby increases cardiovascular mortality. In summary, based on existing evidence in the literature, it appears that simple and inexpensive oral magnesium supplementation may reduce the cardiovascular mortality of patients who are already severely affected by such diseases; in this context, the concept of ‘normal’ vs. ‘ideal’ serum magnesium levels should be carefully re-examined.

show abstract

Urinary magnesium predicts risk of cardiovascular disease in Chronic Kidney Disease stage 1–4 patients

Cited by 7 publications

References 206 publications

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Urinary metabolic profile and stone composition in kidney stone formers with and without heart disease

Hypomagnesemia as a Risk Factor and Accelerator for Vascular Aging in Diabetes Mellitus and Chronic Kidney Disease

Contact Info

Product

Resources

About