Urinary lysosomal enzyme excretion in pregnant women with hypertensive disorders

Torbé, Andrzej; Chłapowska, Ewelina; Szymańska-Pasternak, Jolanta; Sulecka, Aneta; Bober, Joanna; Kwiatkowska, Ewa; Kwiatkowski, Sebastian; Rzepka, Rafał; Konstanty-Kurkiewicz, Wioletta; Torbé, Bogdan

doi:10.3109/10641955.2014.898305

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Another type of activity presented by the PPAQ-PL questionnaire is passive rest (watching TV or video, using the computer, talking on the phone); in our study, the results in women in the second and third trimesters accounted for 24.1% and 14.5% of CA, respectively. The results of other authors' studies (Torbé et al 2013) confirm that pregnant women are reluctant to engage in physical activity and prefer passive rest, but in our study, ladies who were in the second trimester of pregnancy rested more, while pregnant women in the third trimester clearly limited passive rest.…”

Section: Third Trimestersupporting

confidence: 80%

Evaluation of physical activity of women in the second and third trimester of pregnancy using the standardized PPAQ questionnaire-a pilot study

Plachetka,

Głowacka,

Grajek

et al. 2023

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Pregnancy is a unique period in a woman's life, so every pregnant woman should be aware of the importance of physical exercise during pregnancy. The purpose of this study was to compare the physical activity of women in the second and third trimesters of pregnancy. The standardized Physical Activity Questionnaire for Pregnant Women (PPAQ-PL) was used to achieve the purpose of the study. Thirty women in the age range of 18-35 years (28 years±3.54) participated in the study. Analysis of the results showed that higher values of total weekly energy expenditure were obtained by the group of women in the third trimester of pregnancy (206.37 MET/h/week) compared to pregnant women in the second trimester (140.42MET/h/week). The women differed in terms of energy expenditure in activities such as housework (in women in the second trimester 49.1% of total activity, in the third trimester 56.7%), passive rest (24.1% and 14.5%), professional work (12.9% and 7.7%), sports and exercise (2.8% and 6.6%), and moving around (10.6% and 14.5%). In both women in the second and third trimesters of pregnancy, a low level of activity intensity prevailed (58.08% and 55.64%). Energy expenditure on sports and exercise consistent with the recommended for the second trimester (≥28 MET/h/week) was declared by only 6% of the women surveyed, while in the third trimester the recommended energy expenditure on physical activity (≥16 MET/h/week) was fulfilled by 29% of pregnant women. There is an ongoing need to educate women about the benefits of systematic prenatal activity.

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Section: Third Trimestersupporting

confidence: 80%

Evaluation of physical activity of women in the second and third trimester of pregnancy using the standardized PPAQ questionnaire-a pilot study

Plachetka,

Głowacka,

Grajek

et al. 2023

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Vascular and renal mechanisms of preeclampsia

Wang

Shields

Ekperikpe

et al. 2023

Current Opinion in Physiology

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Proteinuria is Associated with Urinary Loss of Cubilin and Vitamin D-Binding Protein in Patients with Preeclampsia

Albejante

Kunz

Ferreira

et al. 2020

Sci Rep

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Women with preeclampsia (PE) form a vulnerable group for vitamin D3 deficiency. Reabsorption of vitamin D3 occurs in the proximal tubule after being endocytosed in combination with DBP (vitamin D binding protein) by the megalin/cubilin receptor. Because proteinuria promotes tubule injury and dysfunction, we hypothesized that the proteinuria present in pe could promote the loss of these components into the urine. Twenty preeclamptic patients and ten normal pregnant women with a gestational age greater than 20 weeks composed three groups: NC, normotensive control pregnant patients; PE, non-proteinuric preeclamptic patients; and PPE, preeclamptic patients with proteinuria. When proteinuria was absent, preeclampsia was diagnosed accordingly to the American college of Obstetricians and Gynecologists' (ACOG) guideline. The presence of 24-hour proteinuria equal to or greater than 300 mg was considered to form the PPE group. Urinary cubilin, megalin, and DBP were measured by ELISA and normalized by urinary creatinine. Regarding gestational age, there was no difference between the groups. NC group had arterial pressure within normal values, whereas PE and PPE groups had a significant increase (p < 0.01). As expected, PPE group presented elevated ACR (p < 0.05), accompanied by large amounts of cubilin and DBP in the urine (p < 0.05 vs. NC and PE). No difference was found in urinary megalin. PPE patients showed more chance of shedding cubilin into the urine compared to non-proteinuric patients (odds ratio 12.7 (1.2-136.3). In conclusion, this study further tightens the relationship between pe and vitamin D 3 deficiency, since proteinuria present in pe induces the loss of molecules responsible for renal tubular vitamin D 3 reabsorption for subsequent activation. Combined with other factors, the proteinuria may intensify vitamin D 3 deficiency in PE. Preeclampsia (PE) is a multisystem disorder of pregnancy in which renal damage has a significant contribution. A set level of proteinuria has been used to predict high-risk groups and define treatment for PE. In terms of physiopathology, proteinuria emerges due to processes that disturb the glomerular filtration barrier. Besides the classical mechanisms of glomerular damage such as endotheliosis and loss of podocytes 1,2 , an evidence for tubular injury have also been reported. Markers of proximal tubule injury such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and retinol-binding protein (RBP) were higher in the urine of PE patients than in urine of healthy pregnancies 3 In addition, urinary lysosomal enzyme excretion is elevated in patients with PE compared to a pregnant woman with chronic hypertension 4. Burwick et al. demonstrated that pregnancies affected by severe PE have high amounts of KIM-1 in the urine, which was closely correlated with urinary complement activation products, suggesting that tubular injury in PE is intensified by inflammation-activated complement 5. Direct effects of proteinuria on tubular cell damage have been ...

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Urinary lysosomal enzyme excretion in pregnant women with hypertensive disorders

Cited by 5 publications

References 19 publications

Evaluation of physical activity of women in the second and third trimester of pregnancy using the standardized PPAQ questionnaire-a pilot study

Evaluation of physical activity of women in the second and third trimester of pregnancy using the standardized PPAQ questionnaire-a pilot study

Vascular and renal mechanisms of preeclampsia

Proteinuria is Associated with Urinary Loss of Cubilin and Vitamin D-Binding Protein in Patients with Preeclampsia

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