Urinary L-FABP as a marker of vesicoureteral reflux in children: could it also have a protective effect on the kidney?

Benzer, Meryem; Neijmann, Şebnem Tekin; Gültekin, Nazlı Dilay; Tekin, Aslı Uluturk

doi:10.1007/s11255-016-1389-6

Cited by 8 publications

(10 citation statements)

References 44 publications

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“…Several studies have proved that L-FABP is a promising biomarker of various kidney diseases as type 2 diabetes, vesicoureteral reflux, and B12 deficiency [21][22][23]. In the current study, urinary L-FABP was significantly higher in T1D subjects than in controls and also in the diabetic group it was significantly higher in microalbuminuric than in normoalbuminuric diabetic subjects.…”

Section: Discussionsupporting

confidence: 61%

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

AbuShady

Fathy

et al. 2018

Asian J Pharm Clin Res

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Objectives: Renal failure and premature mortality are fatal prognosis of diabetic nephropathy. To improve patient outcome, early diagnosis of diabetic nephropathy is necessary. The study was designed to evaluate urinary liver-type fatty acid binding protein (L-FABP), as an early biomarker of tubulointerstitial injury, and its association with the clinical characteristics of type 1 diabetic children.Methods: Fifty randomly selected patients with type 1 diabetes mellitus (DM) attending the diabetes outpatient clinic of Ain Shams University Children’s Hospital were included in the study. 50 age and sex-matched healthy subjects were enrolled as controls. Urinary L-FABP, 24 h urine albumin, hemoglobin A1c (HbA1c), serum creatinine, and lipid profile were measured.Results: Diabetic subjects had higher mean urinary L-FABP than controls (p<0.05). In microalbuminuric diabetic subjects, the mean urinary L-FABP was detected to be significantly higher than that in normoalbuminuric diabetic subjects, and significantly higher values of the mean urinary L-FABP were detected in the microalbuminuric and the normoalbuminuric subjects than the controls (p<0.05). Multiple linear regression analysis showed that duration of DM and HbA1c was the main predictors of urinary L-FABP in diabetic subjects.Conclusion: In patients with childhood-onset T1D, urinary L-FABP may be used as an indicator of renal injury in early stages of nephropathy, even in the normoalbuminuric state.

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Section: Discussionsupporting

confidence: 61%

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

AbuShady

Fathy

et al. 2018

Asian J Pharm Clin Res

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“…This matter makes them obese, and the high BMI index is a known risk factor for lower levels of response to hepatitis B vaccine. [ 15 16 17 18 29 30 ] This explanation may be the probable reason for the lower levels of response to the hepatitis B vaccine in students of our study and those of other countries. Baba Mahmoodi[ 29 ] reported that smoking and obesity had negative effects on the production of antibodies after vaccination with hepatitis B.…”

Section: Discussionmentioning

confidence: 67%

“…Low levels of response to hepatitis B vaccine in students with higher levels of BMI is maybe due to the distribution of vaccine in fat not in muscle which decrease its absorption. Significant effects of age and BMI on the levels of response to hepatitis B vaccine have been reported from Belgium,[ 15 ] China,[ 16 ] Turkey,[ 17 ] and Iran. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of response to hepatitis B vaccine in iranian 6–18-year-old students

Jouneghani

Chaleshtori

Khoshdel³

et al. 2017

J Res Med Sci

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Background:Hepatitis B is a dangerous disease with high morbidity and mortality rates all around the world. Vaccination is the most important way to its prevention and control. This cross-sectional study was carried out to study the levels of immunogenicity to hepatitis B vaccine in students.Materials and Methods:Six hundred and forty-four students aged 6–18 years including 316 girls and 328 boys were selected from the Chaharmahal Va Bakhtiari province. Selected students had been received three doses of recombinant vaccine (0, 1, and 6 months). Blood samples were taken and the titers of hepatitis B surface antigen were studied.Results:From a total of 644 students, 396 (61.5%) had a titer lesser than 10 mIu/ml and 248 (38.5%) had a titer higher than 10 mIu/ml. Therefore, the level of respond to vaccine with 95% confidence was 38.5% (34.7%–42.4%). Levels of respond to vaccine were related to age, body mass index (BMI), and educational level and were not related to sex and habit of students.Conclusion:Reverse significant relation was seen between the respond to vaccine and age and BMI in a way which the titers of antibody were lower in students with higher age and BMI.

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“…The proposed option for the cure of this disease and to make blood flow better is to use a bioengineered vein (silver microchannel) in the varicose vein. There are similar examples of stent implantation [ 82 , 83 , 84 , 85 ]. The bioengineered blood vessel also appears to be safe for dialysis process.…”

Section: Resultsmentioning

confidence: 99%

Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins

et al. 2017

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Bioengineered veins can benefit humans needing bypass surgery, dialysis, and now, in the treatment of varicose veins. The implant of this vein in varicose veins has significant advantages over the conventional treatment methods. Deep vein thrombosis (DVT), vein patch repair, pulmonary embolus, and tissue-damaging problems can be solved with this implant. Here, the authors have proposed biomedical microdevices as an alternative for varicose veins. MATLAB and ANSYS Fluent have been used for simulations of blood flow for bioengineered veins. The silver based microchannel has been fabricated by using a micromachining process. The dimensions of the silver substrates are 51 mm, 25 mm, and 1.1 mm, in length, width, and depth respectively. The dimensions of microchannels grooved in the substrates are 0.9 mm in width and depth. The boundary conditions for pressure and velocity were considered, from 1.0 kPa to 1.50 kPa, and 0.02 m/s to 0.07 m/s, respectively. These are the actual values of pressure and velocity in varicose veins. The flow rate of 5.843 (0.1 nL/s) and velocity of 5.843 cm/s were determined at Reynolds number 164.88 in experimental testing. The graphs and results from simulations and experiments are in close agreement. These microchannels can be inserted into varicose veins as a replacement to maintain the excellent blood flow in human legs.

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Urinary L-FABP as a marker of vesicoureteral reflux in children: could it also have a protective effect on the kidney?

Cited by 8 publications

References 44 publications

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

Evaluation of response to hepatitis B vaccine in iranian 6–18-year-old students

Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins

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