Urinary kidney injury molecule-1 levels in renal stone patients

Balasar, Mehmet; Pişkin, Mehmet Mesut; Topcu, Cemile; Demir, Lütfi Saltuk; Gürbîlek, Mehmet; Kandemir, Abdülkadir; Öztürk, Ahmet

doi:10.1007/s00345-016-1765-y

Cited by 19 publications

(11 citation statements)

References 26 publications

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“…Dede et al [28] stated in their study that post-RIRS second hour KIM-1/Cr ratio was high; yet, KIM-1/Cr levels returned to preoperative levels 24 h after surgery. Balasar et al [30] found that urine KIM-1/Cr ratios of kidney stone patients who underwent PNL and RIRS increased to the postoperative 4th h and decreased below the preoperative value on the 14th day. They stated in their study that with the increase of stone load, KIM-1/Cr levels elevated as well.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

et al. 2021

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Introduction: Kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are the leading novel biomarkers used efficiently in acute kidney injury (AKI). The levels of these biomarkers increase especially in the early period of nephrotoxic and ischemic renal damage. In this study, we aimed to investigate the clinical importance of NGAL and KIM-1 biomarkers used in the effective evaluation of kidney functions in patients with acute unilateral obstructive stone disease (AUOSD) in the management of endoscopic surgery. Materials and Methods: We prospectively included patients who underwent endoscopic surgery due to AUOSD between January 2018 and December 2019. Urine KIM-1 and NGAL values of the patients were measured preoperative period, postoperative 4th h, and postoperative 7th day. The patients were evaluated according to the location and size of the stone, the degree of renal hydronephrosis, the duration of the operation, complications, and JJ stent placement. Results: The study enrolled 50 patients. Urinary KIM-1/Cr and urinary NGAL/Cr ratios were higher in postoperative 4th h than in others (p < 0.001). Also, we found that urinary KIM-1/Cr and urinary NGAL/Cr ratios with Grade 2 and higher hydronephrosis were statistically higher than Grade 0–1 hydronephrosis (p < 0.001 and p: 0.042, respectively). Additionally, a preoperative urinary KIM-1 value of 1.24 ng/mL had a sensitivity of 78% and a specificity of 63% to predict the presence of hydronephrosis. When urine KIM-1 and NGAL results were compared with surgery time, stone size and location, serum creatinine (sCr) value, and Post-Ureteroscopic Lesion Scale grade, the difference was not statistically significant. Postoperative 7th day NGAL/Cr and KIM-1/Cr ratios were statistically higher in those with JJ stents placed (p: 0.03 and p: 0.004, respectively). Conclusion: KIM-1 and NGAL can be used in our assessment of renal function in patients with AUOSD, even if sCr is normal. Also, these biomarkers can predict the presence of hydronephrosis. It can be helpful in determining the time of surgical treatment, as well as providing information in the follow-up of patients with JJ stents after treatment.

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Section: Discussion/conclusionmentioning

confidence: 99%

Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

et al. 2021

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“…Under normal conditions, KIM-1 is absent in the urine; however, it is increased after the development of the following conditions: acute renal failure (caused by ischemia or nephrotoxicity), urolithiasis (particularly in patients who underwent surgical treatment), and cystic kidney disease [ 8 , 31 , 32 ]. Kidney injury molecule-1 expression was found to be significantly associated with glomerular disease and interstitial damage [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Are there any new reliable markers to detect renal injury in obese children?

et al. 2018

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Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children.Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured.Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05).Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.

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“…measured preoperative and postoperative urine KIM-1/Cr levels in patients with micro PNL, RIRS, and PNL. A signi cant decrease was detected in postoperative KIM-1/Cr levels in RIRS and PNL grougroupspared to micro PNL at the end of the study (p = 0.010, p = 0.001 respectively) (20). In another study, KIM-1/Cr and NGAL/Cr levels were detected two hours after the operation at a statistically signi cantly increased level compared to preoperative levels (p = 0.04, p = 0.02 respectively Preoperative KIM-1/Cr levels show the homogeneous distribution of the groups.…”

Section: Discussionmentioning

confidence: 86%

Comparison of retrograde intrarenal stone surgery with and without a ureteral access sheath using Kidney Injury Molecule-1 (KIM-1) levels: A prospective randomized study.

Ecer¹,

Sönmez²,

Aydın³

et al. 2022

European Urology Open Science

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Urinary kidney injury molecule-1 levels in renal stone patients

Abstract: In renal stone patients, the elevated urine KIM-1/Cr ratio levels increase further according to stone size. KIM-1/Cr ratio is a promising marker might be helpful in monitoring the damage created by stone disease.

Cited by 19 publications

References 26 publications

Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

Are there any new reliable markers to detect renal injury in obese children?

Comparison of retrograde intrarenal stone surgery with and without a ureteral access sheath using Kidney Injury Molecule-1 (KIM-1) levels: A prospective randomized study.

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