Urinary Interleukin 18 for Detection of Acute Kidney Injury: A Meta-analysis

Liu, Yawei; Guo, Weijian; Zhang, Jiayou; Xu, Chao; Yu, Shengqiang; Mao, Zhiguo; Wu, Jun; Ye, Chaoyang; Mei, Changlin; Dai, Bing

doi:10.1053/j.ajkd.2013.05.014

Cited by 107 publications

(82 citation statements)

References 45 publications

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“…Studies involving 258 patients who underwent coronary artery bypass surgery confirmed that IL-18 could predict AKI after coronary artery bypass surgery [81,88,89]. However, some researchers have also indicated that IL-18 appears not to be valuable in identifying patients who develop AKI after cardiac surgery [90,91].…”

Section: Interleukin-18 (Il-18) and Il-6mentioning

confidence: 99%

Early Predictors of Acute Kidney Injury: A Narrative Review

Liu

Guan

et al. 2016

Kidney Blood Press Res

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Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient. More ideal biomarkers are needed to be identified. Therefore, future studies are necessary to explore more effective biomarkers for AKI clinical practice, which would play an important role in the early diagnosis and intervention treatment of AKI. This review summarizes the important biomarkers identified by previous studies and aims to highlight the advancements that might provide new methods for early clinical diagnosis and effective therapeutic options, along with prediction of response to treatment for AKI.

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Section: Interleukin-18 (Il-18) and Il-6mentioning

confidence: 99%

Early Predictors of Acute Kidney Injury: A Narrative Review

Liu

Guan

et al. 2016

Kidney Blood Press Res

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“…In addition, NGAL, a protein expressed in neutrophils and renal tubular cells as well as in organs other than the kidney [31,] has been investigated as biomarker in urine and plasma for prediction and prognosis of AKI [32]. Other biomarkers found to be useful for predicting AKI in various clinical settings like cardiac surgery or intensive care units include urinary Interleukin-18 [33] and L-FABP [34]. Finally, the combination of the 2 cell-cycle arrest markers TIMP-2 and IGFBP-7, currently the only FDA-approved diagnostic for AKI, was found to predict the development of AKI with an AUC of at least 0.8 when combined both in critically ill patients [25] and in patients following cardiac surgery [35].…”

Section: Biomarkers In Urine and Bloodmentioning

confidence: 99%

Oliguria and Biomarkers of Acute Kidney Injury: Star Struck Lovers or Strangers in the Night?

Lehner

Forni

Joannidis

2016

Nephron

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Oliguria is a common phenomenon that is found in hospitalized patients . Although a rapid reduction in urine excretion rate may reflect a precipitous fall in the glomerular filtration rate, in many cases it may not. Given the common physiological finding of oliguria, we explore the relationship between the functional biomarker of renal injury (oliguria) with the increasing number of markers of renal injury to see if this combination may aid in risk stratification.

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“…118 Parikh et al 102 evaluated the role of urinary NGAL and IL-18 to predict delayed graft function in kidney transplanted patients from cadaver donors: urinary IL-18 (like urinary NGAL) represents an early, predictive biomarker of delayed graft function after kidney transplantation. 102 Urinary IL-18, like urinary NGAL, is an early noninvasive, accurate predictor of the need for dialysis within the first week after kidney transplantation.…”

mentioning

confidence: 99%

The potential use of biomarkers in predicting contrast-induced acute kidney injury

Andreucci¹,

Faga²,

Riccio³

et al. 2016

IJNRD

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Contrast-induced acute kidney injury (CI-AKI) is a problem associated with the use of iodinated contrast media, causing kidney dysfunction in patients with preexisting renal failure. It accounts for 12% of all hospital-acquired kidney failure and increases the length of hospitalization, a situation that is worsening with increasing numbers of patients with comorbidities, including those requiring cardiovascular interventional procedures. So far, its diagnosis has relied upon the rise in creatinine levels, which is a late marker of kidney damage and is believed to be inadequate. Therefore, there is an urgent need for biomarkers that can detect CI-AKI sooner and more reliably. In recent years, many new biomarkers have been characterized for AKI, and these are discussed particularly with their use in known CI-AKI models and studies and include neutrophil gelatinase-associated lipocalin, cystatin C (Cys-C), kidney injury molecule-1, interleukin-18, N-acetyl-β-d-glucosaminidase, and L-type fatty acid-binding protein (L-FABP). The potential of miRNA and metabolomic technology is also mentioned. Early detection of CI-AKI may lead to early intervention and therefore improve patient outcome, and in future any one or a combination of several of these markers together with development in technology for their analysis may prove effective in this respect.

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Urinary Interleukin 18 for Detection of Acute Kidney Injury: A Meta-analysis

Cited by 107 publications

References 45 publications

Early Predictors of Acute Kidney Injury: A Narrative Review

Early Predictors of Acute Kidney Injury: A Narrative Review

Oliguria and Biomarkers of Acute Kidney Injury: Star Struck Lovers or Strangers in the Night?

The potential use of biomarkers in predicting contrast-induced acute kidney injury

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