Urinary infection, renal lithiasis and bladder cancer in Spain

González, Carlos; Errezola, M.; Izarzugaza, Isabel; López‐Abente, Gonzalo; Escolar, Antonio; Nebot, M; Riboli, Elio

doi:10.1016/0277-5379(91)90395-t

Cited by 36 publications

(27 citation statements)

References 7 publications

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“…Alternatively, UTIs may have a later-stage effect in bladder carcinogenesis by promoting initiated tumors (La Vecchia et al, 1991). In addition, studies that found increased risks from UTIs (Claude et al, 1986;Kantor et al, 1988;Gonzalez et al, 1991) did not discriminate between the different types of UTI. This is an important consideration, as different types of UTI may have different impacts on bladder cancer risk.…”

Section: Discussionmentioning

confidence: 94%

“…A number of case -control studies have examined the possible association of UTIs with bladder cancer in developed countries (Howe et al, 1980;Kantor et al, 1984;Claude et al, 1986;Piper et al, 1986;Kjaer et al, 1989;Gonzalez et al, 1991;La Vecchia et al, 1991;Sturgeon et al, 1994;Jhamb et al, 2007). The overall evidence supports an increased risk from UTIs.…”

Section: Discussionmentioning

confidence: 99%

“…The overall evidence supports an increased risk from UTIs. However, in general, a much higher risk was observed for infections occurring approximately within 5 years of cancer diagnosis, and the risk was substantially reduced or disappeared when infections occurred many years before cancer diagnosis (Howe et al, 1980;Gonzalez et al, 1991;La Vecchia et al, 1991;Jhamb et al, 2007). As the dates of UTIs were not obtained in all these studies, it is also possible that the occurrence of UTIs may be a consequence of early bladder cancer before its diagnosis, rather than a cause of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…An experimental study in rats has shown associations between chronic infections with Escherichia coli and early bladder neoplasia (Davis et al, 1991), and it has been suggested that the high rates of bladder cancer in some parts of Africa and the Middle East may be due to the high prevalence of chronic infection with Schistosoma haematobium (IARC, 1994). A review of published epidemiological studies regarding the association between bladder infections and transitional cell carcinoma (TCC), the predominant type in developed countries, shows inconsistent results (Howe et al, 1980;Kantor et al, 1984;Claude et al, 1986;Piper et al, 1986;Kjaer et al, 1989;Gonzalez et al, 1991;La Vecchia et al, 1991;Sturgeon et al, 1994;Jhamb et al, 2007) and reveals a need for future studies to determine whether UTIs increase the risk of bladder cancer.…”

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confidence: 99%

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Urinary tract infections and reduced risk of bladder cancer in Los Angeles

et al. 2009

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We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a populationbased case -control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46 -0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18 -0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Urinary tract infections and reduced risk of bladder cancer in Los Angeles

et al. 2009

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“…Urinary tract infections have been associated with bladder cancer risk in many case -control studies (Howe et al, 1980;Kantor et al, 1984;Claude et al, 1986;Piper et al, 1986;Gonzalez et al, 1991;La Vecchia et al, 1991). In one study, increased risk was observed among individuals who reported their first UTI 15 or more years before diagnosis (OR ¼ 2.3, 95% CI ¼ 1.0 -5.2) (La Vecchia et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Gonorrhoea and male bladder cancer in a prospective study

2006

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Diet and bladder cancer in Spain: A multi‐centre case‐control study

Riboli

González²,

López‐Abente

et al. 1991

Intl Journal of Cancer

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124

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A multi-centre case-control study on bladder cancer and diet was carried out in 5 regions of Spain. We report results on 432 male cases and 792 matched controls. Usual dietary habits were investigated by means of an interview-based dietary history questionnaire. Bladder-cancer cases were selected from the registers of 12 hospitals located in the study areas. Each case was matched by sex, age and area of residence to 2 controls, one identified in the same hospital and one drawn from population lists. Descriptive analyses indicated that the average dietary pattern was typical of Mediterranean populations: a high P/S ratio, high intake of fish, fruits and vegetables and moderate or low intake of meat and dairy products. Relative risks for specific foods and nutrients were adjusted for tobacco smoking and energy intake. Subjects in the highest quarter of intake of saturated fat had a significantly increased risk of bladder cancer (RR for highest quarter = 2.25; 95% CI = 1.42 to 3.55). Moderate increases in risk for high intake of mono-unsaturated fats and calcium, and a slight decrease for iron were also found, but these disappeared after adjustment for saturated fat. Intake of vitamin E was related to slightly reduced risk (RR for highest quarter = 0.72; 95% CI = 0.48 to 1.09) which was not modified by adjustment for fat. No association was found with intake of retinol or carotene. These results, along with those of previous studies, suggest that saturated fat intake may influence the occurrence of bladder cancer.

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Urinary infection, renal lithiasis and bladder cancer in Spain

Cited by 36 publications

References 7 publications

Urinary tract infections and reduced risk of bladder cancer in Los Angeles

Urinary tract infections and reduced risk of bladder cancer in Los Angeles

Gonorrhoea and male bladder cancer in a prospective study

Diet and bladder cancer in Spain: A multi‐centre case‐control study

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