Urinary Incontinence in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome Is Independent of Treatment Strategy

An accessory cavitated uterine mass (or malformation) (ACUM) is an isolated cystic uterine lesion located at the lateral aspect of the myometrium just below the insertion of the round ligament. Often the source of severe dysmenorrhea and pelvic pain, this condition is classified as a Müllerian abnormality. Understanding ACUMs, recognizing their clinical appearance, diagnosing an ACUM with ultrasound or magnetic resonance imaging, and advising patients about conservative, medicinal, and surgical treatment options is important to all clinicians. Although ACUM primarily presents with severe dysmenorrhea but can have other clinical symptoms, we have provided a few sample cases to help clinicians prepare for ACUM encounters. We also reviewed the other published literature available on ACUM regarding clinical presentation, etiology, and management. Last but not least, based on our research and the work of others, we offer a set of characteristics that will be useful in diagnosing and treating ACUM. ACUM diagnosis is crucial in clinically suspicious circumstances, and early treatment significantly enhances patients' quality of life.

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“…By the end of the first trimester, other Müllerian duct structures are complete. 23,24 The two main hypotheses about the emergence of ACUM are:…”

Section: E Ti O Lo Gymentioning

confidence: 99%

Accessory cavitated uterine malformation: Enhancing awareness about this unexplored perpetrator of dysmenorrhea

Mondal

Bhave

2023

Intl J Gynecology & Obste

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“…The further cranial end of MDs from both sides fuse vertically to form the uterine body and cervix, and the caudal part of MDs fuse to form the upper portion of the vagina. The vagina then canalizes and fuses with the embryonic cloaca to complete the vaginal canal [ 9 , 10 ]. Ovarian development in utero, on the other hand, is a complex process.…”

Section: Introductionmentioning

confidence: 99%

“…Four components of the ovaries, namely the surface epithelium, ovarian stroma, primordial germ cells, and sex cords, develop from the coelomic epithelium, sub-coelomic mesoderm, yolk sac endoderm, and invagination of cortical coelomic epithelium, respectively [ 11 ]. Favorable conditions for optimal development of the female genital system are the presence of both functional X chromosomes (46 XX) and the absence of the SRY gene [ 9 ]. Various agents can influence embryogenesis to cause structural abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis of Müllerian Agenesis Causing Congenital Uterine Factor Infertility—A Systematic Review

Dube,

Kar,

Jhancy

et al. 2023

IJMS

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Infertility affects around 1 in 5 couples in the world. Congenital absence of the uterus results in absolute infertility in females. Müllerian agenesis is the nondevelopment of the uterus. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a condition of uterovaginal agenesis in the presence of normal ovaries and the 46 XX Karyotype. With advancements in reproductive techniques, women with MA having biological offspring is possible. The exact etiology of MA is unknown, although several genes and mechanisms affect the development of Müllerian ducts. Through this systematic review of the available literature, we searched for the genetic basis of MA. The aims included identification of the genes, chromosomal locations, changes responsible for MA, and fertility options, in order to offer proper management and counseling to these women with MA. A total of 85 studies were identified through searches. Most of the studies identified multiple genes at various locations, although the commonest involved chromosomes 1, 17, and 22. There is also conflicting evidence of the involvement of various candidate genes in the studies. The etiology of MA seems to be multifactorial and complex, involving multiple genes and mechanisms including various mutations and mosaicism.

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“…The copyright holder for this preprint this version posted January 21, 2023. ; https://doi.org/10.1101/2023.01.19.524743 doi: bioRxiv preprint 4 conflicting evidence suggests a potential mesodermal origin (Boutin et al, 1992;Hardy, 2010;Moncada-Madrazo and Rodríguez Valero, 2022). Oral epithelia, including the tonsils, are derived from both the ectoderm and the endoderm (Grevellec and Tucker, 2010;Rossen and Thomsen, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, the cervical epithelium is likely derived from the endoderm (Robboy et al, 2017), the innermost layer of the developing embryo. In mice, however, conflicting evidence suggests a potential mesodermal origin (Boutin et al, 1992; Hardy, 2010; Moncada-Madrazo and Rodríguez Valero, 2022). Oral epithelia, including the tonsils, are derived from both the ectoderm and the endoderm (Grevellec and Tucker, 2010; Rossen and Thomsen, 2001).…”

Section: Introductionmentioning

confidence: 99%

Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

Jackson

Rajadhyaksha

Loeffler

et al. 2023

Preprint

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Three-dimensional (3D) culturing techniques can recapitulate the stratified nature of multicellular epithelial tissues. Organotypic 3D epithelial tissue culture methods have several applications, including the study of tissue development and function, drug discovery and toxicity testing, host-pathogen interactions, and the development of tissue-engineered constructs for use in regenerative medicine. We grew 3D organotypic epithelial tissues from foreskin, cervix, and tonsil-derived primary cells and characterized the transcriptome of thesein vitrotissue equivalents. Using the same 3D culturing method, all three tissues yielded stratified squamous epithelium, validated histologically using basal and superficial epithelial cell markers. The goal of this study was to use RNA-seq to compare gene expression patterns in these three types of epithelial tissues to gain a better understanding of the molecular mechanisms underlying their function and identify potential therapeutic targets for various diseases. Functional profiling by over-representation and gene set enrichment analysis revealed tissue-specific differences:i.e., cutaneous homeostasis and lipid metabolism in foreskin, extracellular matrix remodeling in cervix, and baseline innate immune differences in tonsil. Specifically, tonsillar epithelia may play an active role in shaping the immune microenvironment of the tonsil balancing inflammation and immune responses in the face of constant exposure to microbial insults. Overall, these data serve as a resource, with gene sets made available for the research community to explore, and as a foundation for understanding the epithelial heterogeneity and how it may impact theirin vitrouse. An online resource is available to investigate these data (https://viz.datascience.arizona.edu/3DEpiEx/).

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Urinary Incontinence in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome Is Independent of Treatment Strategy

Cited by 4 publications

References 0 publications

Accessory cavitated uterine malformation: Enhancing awareness about this unexplored perpetrator of dysmenorrhea

Accessory cavitated uterine malformation: Enhancing awareness about this unexplored perpetrator of dysmenorrhea

Molecular Basis of Müllerian Agenesis Causing Congenital Uterine Factor Infertility—A Systematic Review

Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

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