Urinary incontinence in men: current and developing therapy options

Abstract

The most common form of urinary incontinence in men is urgency incontinence secondary to an OAB, which often co-exists in men, with bladder outflow obstruction (BOO). The pharmacotherapy options to treat OAB include antimuscarinics, β3 agonists and phosphodiesterase inhibitors. Antimuscarinics and β3 agonists are effective in treating OAB, and have been found to have no increased urinary retention risk in the group of patients with co-existing BPO. Emerging medications include the alternative β3 agonists - solabegron and ritobegron. The future may include novel combinations of these therapies.

The efficacy and safety of antimuscarinics for the prevention or treatment of catheter-related bladder discomfort: a systematic review and meta-analysis of randomized controlled trials

“…Five muscarinic receptor subtypes (M1–M5) in vivo mediate distinct physiological functions according to their locations and receptor subtypes (Bai et al 2015 ). All of them have been detected in the bladder; it was thought that the most physiologically relevant subtypes were M2 and M3, with M2 being more abundant in the detrusor muscle but M3 being more active in eliciting detrusor contraction (Burden and Abrams 2016 ). M2 and M3 are mainly located in the detrusor muscle, urothelium, and efferent nerves (Yamanishi et al 2001 ).…”

Research trends of acupuncture therapy on stress urinary incontinence from 1992 to 2022: A bibliometric analysis

“…He contributed to the classification and assessment of male lower urinary tract symptoms [ 44 ] as well as the treatment of male stress urinary [ 45 , 46 ]. He assessed operative procedures [ 47 ], especially for female stress urinary incontinence [ 48 , 49 ]. He also made recommendations for optimizing care for perinatal women [ 50 ] and nocturia patients [ 51 ].…”

Pooled analysis of the efficacy and safety of intraoperative dexmedetomidine on postoperative catheter‐related bladder discomfort

“…18 Thus, most patients may have a strong vocal response, flail limbs, and even attempt to pull out the urinary catheter, which may lead to an increased incidence of sever postoperative complications. 19 We made this pooled analysis from seven high-quality RCTs including 607 participants to compare intraoperative dexmedetomidine administration in postoperative CRBD with placebo. Compared with placebo, patients treated with intraoperative dexmedetomidine had a lower incidence of early postoperative CRBD (0-6 hours), while there was no meaningful difference between the two sets in the incidence of relatively late CRBD at 12 or 24 hours postoperatively.…”

“…Clinically, patients with indwelling urinary catheter are found suffering from a variety of catheter‐related symptoms, such as urgency, frequency, urge incontinence, and suprapubic pain 18 . Thus, most patients may have a strong vocal response, flail limbs, and even attempt to pull out the urinary catheter, which may lead to an increased incidence of sever postoperative complications 19 …”