Urinary high density lipoprotein in minimal change glomerular disease and chronic glomerulopathies

Lopes‐Virella, Maria F.; Virella, Gabriel; DeBeukelaer, Martin M.; Owens, Caroline; Colwell, John A.

doi:10.1016/0009-8981(79)90187-6

Cited by 30 publications

(8 citation statements)

References 16 publications

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“…Raised total plasma triglyceride and cholesterol concentrations have been noted by most investigators [9,[13][14][15][16] and the cholesterol content of very-low-density lipoprotein (VLDL) and LDL fractions is generally raised [14], Levels of HDL cholesterol have been var iously reported as high [17][18][19], normal [15,20,21] or low [13,14,22], Many of these studies lacked a suitable control population, a fact pointed out by Valeri and coworkers [23]. Using a large population of age-and sexmatched controls Appel demonstrated normal or low HDL cholesterol levels in a group of 20 adult nephrotics [9].…”

Section: Lipid and Lipoprotein Abnormalities In Human Nephroticsmentioning

confidence: 99%

Hyperlipidemia in Nephrotic Syndrome

Wheeler

Varghese

Moorhead³

1989

Am J Nephrol

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Section: Lipid and Lipoprotein Abnormalities In Human Nephroticsmentioning

confidence: 99%

Hyperlipidemia in Nephrotic Syndrome

Wheeler

Varghese

Moorhead³

1989

Am J Nephrol

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“…A defective lipolysis of triglyceride-rich lipoproteins Cholesterol synthesis in the liver is increased, and there may be a suppression of LDL receptor activity leading to decreased LDL updue to reduced lipoprotein lipase activity may be respon sible for increased triglycerides. HDL cholesterol is re duced in severe NS by glomerular filtration and urinary excretion [33]. Increased LDL cholesterol and decreased HDL cholesterol are strong risk factors for accelerated atherosclerosis.…”

mentioning

confidence: 99%

Treatment of Hyperlipidemia in Nephrotic Syndrome: Time for a Change?

Olbricht¹,

Koch²

1992

Nephron

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“…HDL levels have been reported to range from low [11] to normal or high [12][13][14], In this study, the HDL level decreased at the acute stage and recovered rapidly through remission. HDL levels in the controls were positively correlated with serum cholesterol levels.…”

Section: Discussionmentioning

confidence: 59%

Lipoprotein Derangement during Steroid Treatment in Minimal-Change Nephrotic Syndrome

Tsukamoto

Kokubo²,

Horii³

et al. 1996

Nephron

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To study the pathophysiology of hyperlipidemia in nephrotic syndrome, we compared lipid metabolism in the nephrotic stage (stage 1) and in stage 2, when albuminuria had subsided, in 11 patients with minimal-change disease treated with corticosteroid. High-density lipoprotein (HDL) levels were decreased and HDL contained more cholesterol and triglyceride per unit of protein in stage 1 in the patients than in age-matched healthy controls. The urinary protein level was positively correlated only with low-density lipoprotein (LDL) levels, suggesting that the increased albumin clearance stimulated LDL production. Serum cholesterol levels were positively correlated with apolipo-protein E levels and were negatively correlated with lecithin-cholesterol acyltransferase activity in the nephrotic stage; the opposite correlations were seen in controls. Although triglycerides in HDL had normalized at stage 2, triglycerides in LDL and very-low-density lipoprotein did not return toward normal until stage 3, when serum cholesterol levels were normalized.

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Urinary high density lipoprotein in minimal change glomerular disease and chronic glomerulopathies

Cited by 30 publications

References 16 publications

Hyperlipidemia in Nephrotic Syndrome

Hyperlipidemia in Nephrotic Syndrome

Treatment of Hyperlipidemia in Nephrotic Syndrome: Time for a Change?

Lipoprotein Derangement during Steroid Treatment in Minimal-Change Nephrotic Syndrome

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