Urinary Gonadotrophin Excretion in Osteoarthritis

Lansbury, John; Fb, Rogers

doi:10.1097/00000441-195610000-00008

Cited by 9 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, experiments with ovarectomized macacs receiving estrogen replacement therapy have revealed a diminished expression of OA (Ham et al 2002). Although numerous groups have studied serum and urinary sex hormone concentrations in women suffering from OA, the way in which estrogens are involved in the pathogenesis of this disease remains unclear (Rogers and Lansbury 1956;Dequeker 1985;Cutollo et al 1986;Spector et al 1987). Several studies have shown that estrogens affect oxidative stress induced by reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

2005

View full text Add to dashboard Cite

Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by incubating them with combined Fe2SO4, vitamin C, and hydrogen peroxide. The release of thiobarbituric-acid-reactive substances (TBARS, lipid peroxidation) and lactate dehydrogenase (LDH, membrane damage) was measured photometrically. Various estradiol doses and vitamin E, serving as control with an established anti-oxidative capacity, were applied either upon each exchange of medium and during radical production (strategy 1) or only during radical production (strategy 2). In chondrocytes incubated according to strategy 1, the production of TBARS and LDH release were significantly suppressed by 10(-10)-10(-4) M estradiol or by vitamin E. Under strategy 2, the production of TBARS was significantly suppressed at estradiol concentrations higher than 10(-6) M, whereas LDH release was inhibited at concentrations of 10(-6)-10(-4) M. Vitamin E showed no significant effects. As repeated application of estradiol and vitamin E produced the best results, estradiol, like vitamin E, was speculated to accumulate in the plasma membrane and to decrease membrane fluidity resulting in protection against lipid peroxidation (non-genomic effect). Thus, in contrast to the neuroprotective effect of 17beta-estradiol in supraphysiological doses reported recently, the anti-oxidative potential of estradiol appears to protect articular chondrocytes from ROS-induced damage when the hormone is given repeatedly in a physiological range. Decreased estradiol levels may therefore contribute to menopausal OA in the long term.

show abstract

Section: Introductionmentioning

confidence: 99%

Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

2005

View full text Add to dashboard Cite

show abstract

Therapeutische Aspekte

Wagenhäuser¹

1984

Rheumatologie B

View full text Add to dashboard Cite

Endogenous sex steroid levels in women with generalised osteoarthritis

1991

View full text Add to dashboard Cite

Epidemiologic and clinical observations have suggested a relationship between generalised osteoarthritis (GOA) and hormonal and menopausal factors in women. We explored the hypothesis that postmenopausal women with GOA have altered sex hormone status compared with control women. We studied 112 women (mean age 64) with GOA. Controls were 151 women (mean age 54) from the general population without clinical evidence of hand or knee OA. All women were postmenopausal. Serum was assayed by RIA for testosterone, oestradiol, sex hormone binding globulin (SHBG), and dyhydroepiandrosterone sulphate (DHEAS). Because of the differences in mean ages, the results were compared according to equal age groups divided on the basis of tertiles. SHBG was lower in the GOA group, reaching significance in the middle group 53-61 years (58.0 vs 67.9 nmol/l p less than 0.05). Testosterone was slightly higher in GOA women aged under 53. No consistent differences were seen in the older age group or for the other sex steroids. These preliminary data suggest that middle-aged women with GOA have lower circulating SHBG levels. This implies that higher circulating free oestrogens and androgens are present suggesting a role in the aetiopathogenesis of GOA.

show abstract

Urinary Gonadotrophin Excretion in Osteoarthritis

Cited by 9 publications

References 0 publications

Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

Therapeutische Aspekte

Endogenous sex steroid levels in women with generalised osteoarthritis

Contact Info

Product

Resources

About