Urinary Glycosaminoglycan Excretion in NIDDM Subjects: Its Relationship to Albuminura

McAuliffe, Aileen V.; Fisher, Elizabeth; McLennan, Susan V.; Yue, Dennis K.; Turtle, John R.

doi:10.1002/(sici)1096-9136(199608)13:8<758::aid-dia160>3.0.co;2-t

Cited by 21 publications

(10 citation statements)

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“…As it has been proposed before that an increased loss of glycosaminoglycans from the GBM alters glomerular charge selectivity, leading to loss of albumin in the urine. [15][16][17]281 Results of biochemical parameters are in agreement with electron microscopic and light microscopic findings. In electron microscopic examination total number of alcian blue stained particles in I pm 2 area on the GBM was decreased in untreated diabetic rats compared with healthy animals.…”

Section: Discussionsupporting

confidence: 75%

“…Tel. : +90 216 4490347, Fax: +90 216 4280013, e-mail: dyavuz@turk.net parameters: albuminuria, which reflects the defect in glomerular permeability, I131 red blood cell anionic charge (RBCCh) that mirrors the electrostatic charge on the glomerular basement membrane, I141 urine glycosaminoglycan, which is the major elements of glomerular anionic barrier, as an marker of GAG loss from GBM, [5][6][7][8][9][10][11][12][13][14][15][16][17] and the glomerular basement membrane heparan sulfate particles distribution and count that represent the charge selective barrier. Il…”

Section: Introductionmentioning

confidence: 99%

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Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

Yavuz

Ersöz

Tuncel

et al. 2001

Journal of Diabetes Research

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We investigated the effect of aminoguanidine (AG) administration on GBM thickness, glomerular heparan sulfate (HS) content, and urinary albumin and HS excretion in diabetic rats. After induction of diabetes, female Wistar rats were divided into 2 groups: Group AGDM (n=11) received 1g/L aminoguanidine bicarbonate in drinking water, group DC (n=12) was given only tap water. Control rats received AG (group AGH, n=8) or tap water (group HC, n=8). At the end of a period of 8 weeks, urinary albumin and glycosaminoglycan (GAG) excretion was detected. GBM heparan sulfate distribution and count was determined under the electron microscope. The AGDM group had lower urinary albumin and GAG excretion than diabetic controls. GBM thickness was increased in diabetic rats compared to groups of AGDM and HC. In AGDM group alcian blue stained particle distribution and count in the GBM was similar to healthy controls. In conclusion AG prevents the decrease of anionic charged molecules in the GBM and GBM thickening. This can be one of the mechanisms by which AG decreases albuminuria in diabetic rats.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

Yavuz

Ersöz

Tuncel

et al. 2001

Journal of Diabetes Research

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“…However, conflicting results have been reported on the urinary glycosaminoglycan excretion in different pathological conditions (13–15). Vermylen et al .…”

Section: Discussionmentioning

confidence: 99%

“…However, conflicting results have been reported on the urinary glycosaminoglycan excretion in different pathological conditions (13)(14)(15). Vermylen et al demonstrated a significant increase in urinary HSPG in children with congenital nephrotic syndrome, and proposed that the basic defect in this disease syndrome was the failure to incorporate HSPG into the macromolecular structure of the GBM, resulting in the loss of HSPG into the urine (16).…”

Section: Discussionmentioning

confidence: 99%

Urinary heparan sulfate proteoglycan excretion in black African women with pre‐eclampsia

Khedun¹,

Naicker

Moodley³

et al. 2002

Acta Obstet Gynecol Scand

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This study demonstrates a reduction of glomerular charge in pre-eclampsia. The strong correlation between the severity of proteinuria and the loss of charge supports the hypothesis that the loss of glomerular charge induces structural changes of the filtration barrier, and may be the mechanism responsible for the proteinuria in pre-eclampsia. Furthermore, the elevated levels of urinary proteoglycan (heparan and chondroitin sulfate proteoglycans) in this disorder show a loss into the urine rather than a neutralization of these macromolecules.

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“…Наибольшие значения зафиксированы у больных с клинически явной ДН (рис. 1), что согласуется с другими данны ми [15,18]. Обнаружена слабая корреляция между показателями экскрецией ГАГ, уровнем гликогемоглобина (г=0,34, р<0,05) и среднесуточной гликемией (г=0,31, р<0,05).…”

Section: результаты и их обсуждениеunclassified

Obmen glikozaminoglikanov i aktivnost' lizosomal'nykh fermentov u bol'nykh s diabeticheskoy nefropatiey

Бондарь¹,

Klimentov²,

Paul³

et al. 2002

Diabetes mellitus

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Urinary Glycosaminoglycan Excretion in NIDDM Subjects: Its Relationship to Albuminura

Cited by 21 publications

References 0 publications

Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

Urinary heparan sulfate proteoglycan excretion in black African women with pre‐eclampsia

Obmen glikozaminoglikanov i aktivnost' lizosomal'nykh fermentov u bol'nykh s diabeticheskoy nefropatiey

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