Urinary fibrin/fibrinogen degradation products measured using an anti‐fibrinogen antibody predict orthostatic proteinuria

Abstract

Comparison of uFDP levels in supine/upright urine can be reliable for diagnosing OP and differentiating it from active GN. This article is protected by copyright. All rights reserved.

Value of micro-proteinuria in combination with ultrasonography of the left renal vein in the diagnosis of orthostatic proteinuria

“…Macro-molecular proteins such as IgG and C3 may appear in the proteinuria upon standing (25). Kanai et al found the comparison of urinary fibrin/fibrinogen degradation products (uFDP) level in supine/upright urine could be reliable for the diagnosis and differentiation of OP and active GN (26). Our results showed Alb/Cr and IgG/Cr in the morning urine were higher than those in the urine collected after activity in the OP group.…”

Orthostatic proteinuria revisited: new clinical impact of the “old” clinical entity?

“…Thus, most cases of OP tend to show spontaneous remission with time and have a favorable long-term prognosis (1,2). However, no validated clinical diagnostic index for differential diagnosis of OP and glomerulonephritis (GN) has been established to date (10)(11)(12). OP is not a new clinical entity but still lacks clear definitive diagnostic criteria.…”

“…To date, some interesting papers that aimed to identify urinary simple biomarkers of OP to determine their diagnostic values have been published (10,12). Previously, Ohshima reported that the ratio of urinary IgG/IgA and serum IgG/IgA were significantly decreased in patients with GN than that in patients with OP (10).…”

“…However, the sample size remained low (n=14) and the diagnosis of OP depended only on the upright lordotic posture test result. Recently, Kanai et al reported that the urinary fibrin/ fibrinogen degradation products (FDP) obtained in the upright position was significantly increased in patients with OP than in patients with GN (12). They concluded that the urinary FDP/Cr ratio showed high sensitivity and specificity in differentiating OP from active GN in either supine or upright position (12).…”

“…Recently, Kanai et al reported that the urinary fibrin/ fibrinogen degradation products (FDP) obtained in the upright position was significantly increased in patients with OP than in patients with GN (12). They concluded that the urinary FDP/Cr ratio showed high sensitivity and specificity in differentiating OP from active GN in either supine or upright position (12). However, the number of subjects was less (n=16) and the diagnosis of OP depended only on the upright lordotic posture test result.…”