Urinary F2‐isoprostanes formation in kidney transplantation

Cracowski, Jean‐Luc; Souvignet, Claude; Quirin, N.; Grosbois, Xavier; Bayle, François; Stanke‐Labesque, Françoise; Vialtel, P; Bessard, Germain

doi:10.1034/j.1399-0012.2001.150110.x

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…Further, on the atherosclerosis mechanism, the presence of F2-isoprostanes has been determined in human atherosclerotic lesions [ 58 ]. F2-isoprostanes are created during the nonenzymatic peroxidation of arachidonic acid bound up with phospholipids of cells membranes and lipoproteins [ 59 – 61 ], and they are considered sensitive and specific indicators of oxidative stress intensity in vivo [ 58 , 62 ]. Given reports, such as [ 50 ], of a significant increase in plasma isoprostanes in HD patients, the link between oxidative stress and CVD in HD patients is further highlighted.…”

Section: Analysis and Discussionmentioning

confidence: 99%

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

Poulianiti

Καλτσάτου

Mitrou

et al. 2016

Oxidative Medicine and Cellular Longevity

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Patients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.

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Section: Analysis and Discussionmentioning

confidence: 99%

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

Poulianiti

Καλτσάτου

Mitrou

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Camphausen [168] Urine Not differed Kidney transplantation Crawcowski [171] Urine Not differed ARDS ¼ Acute respiratory distress syndrome; RVD ¼ Renovascular disease; PCI ¼ Percutaneous coronary intervention.…”

Section: Isoprostanes In Dietary Supplementation Studiesmentioning

confidence: 99%

ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation

Basu

2004

Free Radical Research

202

153

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Isoprostanes, are a novel group of prostaglandin-like compounds that are biosynthesised from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical-catalysed reaction. Several of these compounds possess potent biological activity, as evidenced mainly through their pulmonary and renal vasoconstrictive effects, and have short half-lives. It has been shown that isoprostanes act as full or partial agonists through thromboxane receptors. Both human and experimental studies have indicated associations of isoprostanes and severe inflammatory conditions, ischemia-reperfusion, diabetes and atherosclerosis. Reports have shown that F2-isoprostanes are authentic biomarkers of lipid peroxidation and can be used as potential in vivo indicators of oxidant stress in various clinical conditions, as well as in evaluations of antioxidants or drugs for their free radical-scavenging properties. Higher levels of F2-isoprostanes have been found in the normal human pregnancy compared to non-pregnancy, but their physiological role has not been well studied so far. Since bioactive F2-isoprostanes are continuously formed in various tissues and large amounts of these potent compounds are found unmetabolised in their free acid form in the urine in normal basal conditions with a wide inter-individual variation, their role in the regulation of normal physiological functions could be of further biological interest, but has yet to be disclosed. Their potent biological activity has attracted great attention among scientists, since these compounds are found in humans and animals in both physiological and pathological conditions and can be used as reliable biomarkers of lipid peroxidation.

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“…We envision a potential utility for measuring IsoFs in a wide variety of other settings as diverse as oxidative damage to transplant organs during storage in ambient air (22,23), retinopathy of prematurity (24), and the sequelae of hyperbaric oxygen exposure (25). Additionally, mitochondrial dysfunction can be a source of free radical generation and is a feature of a number of disorders including neurodegenerative diseases such as Parkinson's disease (26,27).…”

Section: Discussionmentioning

confidence: 99%

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel

Porter²,

Moore³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

207

178

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Free radicals have been implicated in the pathogenesis of an increasing number of diseases. Lipids, which undergo peroxidation, are major targets of free radical attack. We report the discovery of a pathway of lipid peroxidation that forms a series of isomers in vivo that are characterized by a substituted tetrahydrofuran ring structure, termed isofurans (IsoFs). We have proposed two distinct pathways by which IsoFs can be formed based on 18 O2 and H2 18 O labeling studies. Measurement of F2-isoprostanes (IsoPs), prostaglandin F2-like compounds formed nonenzymatically as products of lipid peroxidation, is considered one of the most reliable approaches for assessing oxidative stress status in vivo. However, one limitation with this approach is that the formation of IsoPs becomes limited at high oxygen tension. In contrast, the formation of IsoFs becomes increasingly favored as oxygen tension increases. IsoFs are present at readily detectable levels in normal fluids and tissues, and levels increase dramatically in CCl 4-treated rats, an animal model of oxidant injury. The ratio of IsoFs to IsoPs in major organs varies according to normal steady-state tissue oxygenation. In addition, IsoFs show a marked increase early in the course of hyperoxia-induced lung injury, whereas IsoPs do not significantly increase. We propose that combined measurement of IsoFs and IsoPs should provide a more reliable index of oxidant stress severity than quantification of either alone because of the opposing modulation of the two pathways by oxygen tension, which can vary widely in different organs and disease states.

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Urinary F2‐isoprostanes formation in kidney transplantation

Abstract: Our study shows no evidence of enhanced lipid peroxidation in the first 5 d following kidney transplantation.

Cited by 11 publications

References 29 publications

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

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