Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia

Reuter, Stefan; O'Donovan, Donough J; Hegemier, Suzanne; Smith, E. O’Brian; Heird, William C.; Fernandes, Caraciolo J.

doi:10.1038/sj.jp.7211684

Cited by 17 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, hyperoxia limits the formation of IsoPs. Therefore IsoPs are poor prognostic predictive biomarkers for the development of oxygen-derived chronic lung disease in preterm infants [80]. On the contrary, formation of IsoFs becomes favored at higher oxygen tensions rendering these biomarkers especially relevant for clinical research in neonatology and predictive of BPD development [81] (Fig.…”

Section: Introductionmentioning

confidence: 99%

Oxygen and oxidative stress in the perinatal period

et al. 2017

View full text Add to dashboard Cite

Fetal life evolves in a hypoxic environment. Changes in the oxygen content in utero caused by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the mother lead to increased free radical production and correlate with perinatal outcomes.In the fetal-to-neonatal transition asphyxia is characterized by intermittent periods of hypoxia ischemia that may evolve to hypoxic ischemic encephalopathy associated with neurocognitive, motor, and neurosensorial impairment. Free radicals generated upon reoxygenation may notably increase brain damage. Hence, clinical trials have shown that the use of 100% oxygen given with positive pressure in the airways of the newborn infant during resuscitation causes more oxidative stress than using air, and increases mortality.Preterm infants are endowed with an immature lung and antioxidant system. Clinical stabilization of preterm infants after birth frequently requires positive pressure ventilation with a gas admixture that contains oxygen to achieve a normal heart rate and arterial oxygen saturation. In randomized controlled trials the use high oxygen concentrations (90% to 100%) has caused more oxidative stress and clinical complications that the use of lower oxygen concentrations (30–60%). A correlation between the amount of oxygen received during resuscitation and the level of biomarkers of oxidative stress and clinical outcomes was established. Thus, based on clinical outcomes and analytical results of oxidative stress biomarkers relevant changes were introduced in the resuscitation policies. However, it should be underscored that analysis of oxidative stress biomarkers in biofluids has only been used in experimental and clinical research but not in clinical routine. The complexity of the technical procedures, lack of automation, and cost of these determinations have hindered the routine use of biomarkers in the clinical setting. Overcoming these technical and economical difficulties constitutes a challenge for the immediate future since accurate evaluation of oxidative stress would contribute to improve the quality of care of our neonatal patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Oxygen and oxidative stress in the perinatal period

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Therefore, we tested whether urine biomarkers of ROS were associated with GRP levels (Figure 4). We found that urinary GRP was associated with concurrent urinary allantoin ( P = .003), 22 a uric acid oxidation product, and 8‐OHdG ( P = .01), 23 reflecting oxidized nucleic acids, but not with urine 2,3‐dinor iPF2α‐III, a urinary metabolite of the isoprostane, 8‐iso‐PGF2α ( P = .87), 30 a nonenzymatic oxidation product of arachidonic acid. Although BPD has been associated with oxidative stress, 31 in our study cohort, urine biomarkers of ROS in the first postnatal week were not associated with BPD (Table S3).…”

Section: Resultsmentioning

confidence: 84%

“…Interestingly, GRP, 15 8‐OHdG, 23 and allantoin 35 concentrations in the urine reflect levels found in airway surface liquid and in blood. Other ROS biomarkers such as 8‐iso‐PGF2α are present in the airway surface liquid and plasma but are not concentrated in the urine 30 and, therefore, may not be useful as urinary biomarkers for BPD. Thus, although plasma F 2 ‐isoprostane early postbirth is associated with BPD 36 or with increased oxygen requirement at 40 weeks PMA, 37 urinary 8‐iso‐PGF2α is not associated with BPD 30 or, in our cohort study, with levels of urinary GRP.…”

Section: Discussionmentioning

confidence: 99%

Urine gastrin‐releasing peptide in the first week correlates with bronchopulmonary dysplasia and post‐prematurity respiratory disease

Voynow

Fisher

Sunday

et al. 2020

Pediatric Pulmonology

View full text Add to dashboard Cite

Rationale Bronchopulmonary dysplasia (BPD) is associated with post‐prematurity respiratory disease (PRD) in survivors of extreme preterm birth. Identifying early biomarkers that correlate with later development of BPD and PRD may provide insights for intervention. In a preterm baboon model, elevated gastrin‐releasing peptide (GRP) is associated with BPD, and GRP inhibition mitigates BPD occurrence. Objective We performed a prospective cohort study to investigate whether urine GRP levels obtained in the first postnatal week were associated with BPD, PRD, and other urinary biomarkers of oxidative stress. Methods Extremely low gestational age infants (23‐28 completed weeks) were enrolled in a US multicenter observational study, The Prematurity and Respiratory Outcomes Program (http://clinicaltrials.gov/ct2/show/NCT01435187). We used multivariable logistic regression to examine the association between urine GRP in the first postnatal week and multiple respiratory outcomes: BPD, defined as supplemental oxygen use at 36 + 0 weeks postmenstrual age, and post‐PRD, defined by positive quarterly surveys for increased medical utilization over the first year (PRD score). Results A total of 109 of 257 (42%) infants had BPD, and 120 of 217 (55%) had PRD. On adjusted analysis, GRP level more than 80 was associated with BPD (adjusted odds ratio [aOR], 1.83; 95% confidence interval [CI], 1.03‐3.25) and positive PRD score (aOR, 2.46; 95% CI, 1.35‐4.48). Urine GRP levels correlated with duration of NICU ventilatory and oxygen support and with biomarkers of oxidative stress: allantoin and 8‐hydroxydeoxyguanosine. Conclusions Urine GRP in the first postnatal week was associated with concurrent urine biomarkers of oxidative stress and with later diagnoses of BPD and PRD.

show abstract

“…With oxygen toxicity as significant contributor of BPD pathophysiology, some studies aimed to identify metabolite products of oxidant injury in the urine. In one study, F2-isoprostane (F2-IsoP), a metabolite formed by lipid peroxidation of cellular membranes, was measured in 40 preterm infants with and without BPD, but found no significant of F2-IsoP in the neonatal period ( 83 ). In another study, leukotriene E4 (LTE4) and 8-hydroxyguanosine (8-OHdG), two oxidant injury markers, were evaluated in the urine of 60 preterm infants.…”

Section: Biomarkersmentioning

confidence: 99%

Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant

et al. 2016

View full text Add to dashboard Cite

Bronchopulmonary dysplasia (BPD) is a chronic inflammatory lung disease of very-lowbirth-weight (VLBW) preterm infants, associated with arrested lung development and a need for supplemental oxygen. Over the past few decades, the incidence of BPD has significantly raised as a result of improved survival of VLBW infants requiring mechanical ventilation. While early disease detection is critical to prevent chronic lung remodeling and complications later in life, BPD is often difficult to diagnose and prevent due to the lack of good biomarkers for identification of infants at risk, and overlapping symptoms with other diseases, such as pulmonary hypertension (PH). Due to the current lack of effective treatment available for BPD and PH, research is currently focused on primary prevention strategies, and identification of biomarkers for early diagnosis, that could also represent potential therapeutic targets. In addition, novel histopathological, biochemical, and molecular factors have been identified in the lung tissue and in biological fluids of BPD and PH patients that could associate with the disease phenotype. In this review, we provide an overview of biomarkers for pediatric BPD and PH that have been identified in clinical studies using various biological fluids. We also present a brief summary of the information available on current strategies and guidelines to prevent and diagnose BPD and PH, as well as their pathophysiology, risk factors, and experimental therapies currently available.

show abstract

Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia

Cited by 17 publications

References 19 publications

Oxygen and oxidative stress in the perinatal period

Oxygen and oxidative stress in the perinatal period

Urine gastrin‐releasing peptide in the first week correlates with bronchopulmonary dysplasia and post‐prematurity respiratory disease

Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant

Contact Info

Product

Resources

About