Urinary exoglycosidases, reference values in healthy children

Zalewska-Szajda, Beata; Taranta-Janusz, Katarzyna; Chojnowska, Sylwia; Waszkiewicz, Napoleon; Zwierz, Krzysztof; Wasilewska, Anna

doi:10.1016/j.advms.2018.01.004

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…A negative correlation between urinary activity of HEX, HEX A and HEX B (pKat/µg Cr) and age was also found in children and adolescents with SFK and hydronephrosis (21,22) . We showed (46) that urinary activity of FUC, GAL, GLU and MAN in 203 children and adolescents, as in the case of HEX and its isoenzymes, is independent of sex, but depends on age and is statistically significantly higher (p < 0.001) (pKat/μg Cr) in the youngest children (0.5-2.9 years) compared to adolescents (15.0-17.9 years). Furthermore, we showed a negative correlation between the age of children and adolescents and urinary activity (pKat/µg Cr) of FUC (r = −0.36, p < 0.0001); GAL (r = −0.36, p < 0.0001); GLU (r = −0.35, p < 0.0001) and MAN (r = −0.35, p < 0.0001) (46) .…”

Section: Urinary Lysosomal Exoglycosidases In Healthy Children and Ad...mentioning

confidence: 79%

“…We showed (46) that urinary activity of FUC, GAL, GLU and MAN in 203 children and adolescents, as in the case of HEX and its isoenzymes, is independent of sex, but depends on age and is statistically significantly higher (p < 0.001) (pKat/μg Cr) in the youngest children (0.5-2.9 years) compared to adolescents (15.0-17.9 years). Furthermore, we showed a negative correlation between the age of children and adolescents and urinary activity (pKat/µg Cr) of FUC (r = −0.36, p < 0.0001); GAL (r = −0.36, p < 0.0001); GLU (r = −0.35, p < 0.0001) and MAN (r = −0.35, p < 0.0001) (46) . Our study is the first such a large analysis on reference values for urine activity of HEX, its isoenzymes HEX A and HEX B as well as FUC, GAL, GLU and MAN in healthy children and adolescents (42,46) .…”

Section: Urinary Lysosomal Exoglycosidases In Healthy Children and Ad...mentioning

confidence: 79%

“…Our study is the first such a large analysis on reference values for urine activity of HEX, its isoenzymes HEX A and HEX B as well as FUC, GAL, GLU and MAN in healthy children and adolescents (42,46) . The relationship between urinary activity of lysosomal exoglycosidases in children/adolescents and age and the percentile chart within normal values of the 3 rd , 10 th , 25 th , 50 th , 75 th , 90 th and 97 th percentile may be of practical importance for differentiating between healthy and unhealthy children and adolescents (42,46) .…”

Section: Urinary Lysosomal Exoglycosidases In Healthy Children and Ad...mentioning

confidence: 92%

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Lysosomal exoglycosidases in the urine of children and adolescents

Zalewska-Szajda¹,

Taranta-Janusz²,

Gościk³

et al. 2019

PEDIATR MED RODZ

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Standard indices of renal function, i.e. creatinine, glomerular filtration rate (GFR) and endogenous creatinine clearance, still fail to accurately characterise disease processes in kidneys and are not sufficient for proper therapy selection, efficacy prediction and treatment efficacy monitoring for renal diseases. Therefore, markers that allow for an inexpensive, easy and reproducible kidney function assessment should be sought. Lysosomal exoglycosidases, such as N-acetyl-β-D-hexosaminidase (HEX), its isoenzymes A (HEX A) and B (HEX B), α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU) and α-mannosidase (MAN), excreted in minimal amounts in the urine of healthy children and adolescents, yet showing a significant increase in pathological conditions, may be useful in the diagnosis of kidney disease. Such conclusions were a result of our research on the activity of lysosomal exoglycosidases in the urine of healthy children and adolescents compared to children and adolescents with hypertension, ureteropelvic junction obstruction, and congenital or acquired solitary functioning kidney, as well as based on the findings on the urinary activity of lysosomal exoglycosidases in children and adolescents with various kidney diseases, which were obtained by other authors.

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