Urinary Excretion of Uric Acid in the Dalmatian and Non-Dalmatian Dog Following Administration of Diodrast, Sodium Salicylate and a Mercurial Diuretic

Miller, George E.; Danzig, Leonard S.; Talbott, John H.

doi:10.1152/ajplegacy.1950.164.1.155

Cited by 14 publications

(2 citation statements)

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“…Sperling et al 38 suggest that the solubility of uric acid is maintained by THP and that increased uric acid content may result in decreased quantities of THP or reduced activity of THP. Recall that results of some studies 8,[27][28][29][30][31] of purine metabolism in Dalmatians were interpreted to indicate that the magnitude of increased serum and urine uric acid concentrations was similar in males and females. If those observations are valid, they indicate that increased urine uric acid concentration would likely decrease urine THP concentration in male and female Dalmatians and therefore would be unlikely to explain the sex-related difference in detection of urate uroliths.…”

Section: Small Animals/ Exoticmentioning

confidence: 99%

Evaluation of the association between sex and risk of forming urate uroliths in Dalmatians

Albasan

Lulich

Osborne

et al. 2005

javma

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Section: Small Animals/ Exoticmentioning

confidence: 99%

Evaluation of the association between sex and risk of forming urate uroliths in Dalmatians

Albasan

Lulich

Osborne

et al. 2005

javma

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“…In these species serum UA levels only increase to the levels encountered in humans when there is hepatic dysfunction 4,7,10,14,24,30 . However, UA is predominantly excreted in the urine and could be affected by renal insufficiency 17,18,21,23,25,36 .…”

Section: Introductionmentioning

confidence: 99%

The utility of uric acid assay in dogs as an indicator of functional hepatic mass

Hill

Leisewitz

Goddard

2011

J. S. Afr. Vet. Assoc.

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Uric acid was used as a test for liver disease before the advent of enzymology. Three old studies criticised uric acid as a test of liver function. Uric acid, as an end-product of purine metabolism in the liver, deserved re-evaluation as a liver function test. Serumtotal bile acids are widely accepted as the most reliable liver function test. This study compared the ability of serumuric acid concentration to assess liver function with that of serumpre-prandial bile acids in dogs. In addition, due to the renal excretion of uric acid the 2 assays were also compared in a renal disease group. Using a control group of healthy dogs, a group of dogs with congenital vascular liver disease, a group of dogs with non-vascular parenchymal liver diseases and a renal disease group, the ability of uric acid and pre-prandial bile acids was compared to detect reduced functional hepatic mass overall and in the vascular or parenchymal liver disease groups separately. Sensitivities, specificities and predictive value parameters were calculated for each test. The medians of uric acid concentration did not differ significantly between any of the groups, whereas pre-prandial bile acids medians were significantly higher in the liver disease groups compared with the normal and renal disease group of dogs. The sensitivity of uric acid in detecting liver disease overall was 65% while the specificity of uric acid in detecting liver disease overall was 59 %. The sensitivity and specificity of uric acid in detecting congenital vascular liver disease was 68%and 59 %, respectively. The sensitivity and specificity of uric acid in detecting parenchymal liver disease was 63%and 60 %, respectively. The overall positive and negative predictive values for uric acid in detecting liver disease were poor and the data in this study indicated uric acid to be an unreliable test of liver function. In dogs suffering from renal compromise serum uric acid concentrations may increase into the abnormal range due to its renal route of excretion

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Drugs Affecting the Renal Handling of Uric Acid

Fanelli¹

1976

Methods in Pharmacology

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Urinary Excretion of Uric Acid in the Dalmatian and Non-Dalmatian Dog Following Administration of Diodrast, Sodium Salicylate and a Mercurial Diuretic

Cited by 14 publications

References 0 publications

Evaluation of the association between sex and risk of forming urate uroliths in Dalmatians

Evaluation of the association between sex and risk of forming urate uroliths in Dalmatians

The utility of uric acid assay in dogs as an indicator of functional hepatic mass

Drugs Affecting the Renal Handling of Uric Acid

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