Urinary excretion of radium in dogs

Abstract

Three female adult dogs were injected intravenously with single doses of radium-226 chloride ranging from 20 to 40 µc. Periodic sampling of blood with added heparin and of urine using a bladder catheter were performed for total elapsed times of from 1 week to 21 weeks. Analyses were made of radium in the plasma, the plasma ultrafiltrate and in the urine. Creatinine was determined in plasma and urine. Radium clearance (average = 1.6 ml/min.), creatinine clearance (average = 46 ml/min.), percentage of the plasma radium which is ultrafilterable (average = 70%), and percentage of the ultra-filtrate which is resorbed (average = 95.3%) have been calculated on a basis of the data obtained. Comparing these values for radium with other comparable published values for strontium and calcium it is inferred that the differences in urinary excretion of these materials is principally caused by differences in resorption in the kidney tubules.

Renal transtubular flux of electrolytes in dogs with special reference to calcium

“…On the average, 2-4 times more 85Sr than 45Ca was excreted (Table 1). This finding in dogs agrees with earlier reports for rats (Bauer, Carlsson & Tindquist, 1955), rabbits (MacDonald, Noyes & Lorick, 1957), and man (Spencer, Laszlo & Brothers, 1957;Spencer, Li, Samachson & Laszlo, 1960) and a recent report on clearances in dogs (Della Rosa, cited by Hursh, Lovaas, Piccirilli & Putnam, 1960). Sodium. It would appear from the data reported here that sodium flux occurs relatively close to the glomerulus, though perhaps more distally than does calcium flux.…”

Phase I pharmacokinetic and biodistribution study with escalating doses of 223Ra-dichloride in men with castration-resistant metastatic prostate cancer

“…Kidney activity cleared rapidly and was not seen in images acquired later than 4 h post-injection. This is not surprising, since studies by Hursh et al demonstrated that 94–97 % of filtered radium was reabsorbed [36]. Furthermore, a study by Lloyd et al [38] of the pharmacokinetics of 226 Ra in beagles revealed low urinary excretion in the range of 6.5 % in the first 10 days and whole-body retention of 72.67 %, indicating that feces was the main route of excretion.…”