Urinary Excretion of Luteinizing Hormone in Boys and Adult Men

Sciarra, N; Leone, U

doi:10.1677/joe.0.0460229

Cited by 5 publications

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“…of LH per 24 hours). This observation confirms that there is the same sharp rise in the urinary excretion of LH in the female at puberty as is found in the male (Sciarra and Leone, 1970). Moreover, the LH output in normal menstruating women increased with age, but not significantly.…”

Section: Normal Menstruating Womensupporting

confidence: 85%

“…LH output increased significantly with age in both boys and men. The rate of this increase was the same in h t h groups but there was a sharp rise at puberty (Sciarra and Leone, 1970). In the present study we report on the urinary excretion of LH in girls and normal menstruating women with a view to verifying the results obtained in the males and to delineating the change in LH excretion during puberty in the female.…”

supporting

confidence: 62%

“…of LH per 24 hours) was similar to that (29-3 i.u.) observed in adult men (Sciarra and Leone, 1970). Thus, with respect to LH, the pituitary glands of both males and females appear to have the same secretion power but differ in the excretion rate.…”

Section: Normal Menstruating Womenmentioning

confidence: 87%

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Urinary Excretion of Luteinizing Hormone in Girls and Normal Menstruating Women

Sciarra¹,

Maijnelli²

1972

BJOG

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Summary The 24‐hour urinary excretion of luteinizing hormone (LH) was determinded in 24 girls, aged 4 to 11 years, and in 15 normal menstruating women, aged 18 to 44 years, by an immunological method using the haemagglutination inhibition reaction after a tannic acid extraction. LH was detected in every subject investigated. The mean value for urinary LH excretion in girls was equivalent to 3.8 i.u. (2nd IRP‐HMG) per 24 hours (range 1.2–8.0) and was 29.8 i.u. per 24 hours (range 24.0 to 38.0) in adult women. In girls the LH output increased significantly with age. In normally menstruating adult women, the LH output increased slightly but not significantly with age.

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Section: Normal Menstruating Womensupporting

confidence: 85%

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confidence: 62%

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Urinary Excretion of Luteinizing Hormone in Girls and Normal Menstruating Women

Sciarra¹,

Maijnelli²

1972

BJOG

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“…of FSH and 6.5 i.u. of LH (Sciarra and Leone, 1970). However, a positive test might be obtained with urinary and serial extracts from intact human subjects because of cross-reaction between HCG and LH (Wide, Roos andGemzell, 1961 : Leone andSciarra, 1966).…”

Section: Zmnzunoassaymentioning

confidence: 99%

Human Chorion1c Gonadotrophin in Hydatidiform Moles

Sciarra

1970

BJOG

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The concentration of human chorionic gonadotrophin in fluid content from differently-sized groups of hydatid vesicles, serum and urine was determined in five patients with hydatidiform mole by an immunological method. The HCG concentration of fluid content from small hydatid vesicles (0.3-0-7 cm. in diameter) was significantly higher than that of fluid content from large hydatid vesicles (0.8-1.2 cm.). The HCG value of serum was always much lower than that of fluid content from both small and large hydatid vesicles. The vesicle/serum ratio of HCG concentration ranged from about 1 . 5 to 4.5. The urinary level of the hormone was higher than that of both serum and vesicular fluid, except in one case. The results have been related to the different hypotheses of the pathogenesis of hydatidiform mole. The results seem to support Hertig's hypothesis which considered (1) the trophoblastic hyperplasia to be a result of the enlargement of the villusvesicle and (2) the hydatid fluid to be a product of the active trophoblastic tissue of the mole.

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“…Several authors have demonstrated measurable gonadotropin levels in serum [5,18,26,53] and in urine [11,24,35,43] of prepubertal males, but the relation of these levels to testosterone secretion has not been clearly eludicated. Some authors [3,43] have reported gradually rising excretion of luteinizing hormone (LH) in urine of males during childhood, with a more abrupt 2-fold increase at puberty. Buckler and Clayton [4] showed low LH excretion levels from age 3 months to 6 years, after which gradually rising levels were seen, with a further marked increase at puberty.…”

Section: Introductionmentioning

confidence: 99%

Pituitary-Gonadal Relations in Male Children and Adolescents

1972

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ExtractData are provided on levels of circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone in healthy male children and adolescents, and these levels are correlated with the stage of sexual maturation, bone maturation, whole body 40 K content, and the 24-hr excretion of creatinine, estrogens, 17-hydroxycorticosteroids, total 17-ketosteroids, and fractionated ll-deoxy-17-ketosteroids (see Tables I and II).Before age 6 there was no significant change with age in testis size or hormone concentrations. From age 6-10 years there was a gradual rise in testis size (Fig. 1), serum FSH (Fig. 4) and serum LH (Fig. 3), but no change in plasma testosterone (Fig. 2), which remained below 40 ng/100 ml. From age 11-17 years there was a doubling of mean testis length, continued rise in serum FSH, and a steeper rise in LH; these changes were accompanied by a 20-fold increase in plasma testosterone concentration, the appearance of male secondary sexual characteristics ( Figure 5), more rapid bone maturation and whole body 40 K accretion, and enhanced excretion of estrogens and ll-deoxy-17-ketosteroids. Mean levels of FSH in the adult range (>10 jug/100 ml) were achieved by age 8, and levels reached a plateau by age 15 (Fig. 6). Adult LH levels ( >2.5 ^g/100 ml) were reached by age 13 and a plateau was observed after 17 years. Plasma testosterone also ceased to rise after age 17.The data suggest that the testis may undergo progressive gonadotropin-mediated maturation in late childhood. Testosterone secretion by the Leydig cells at puberty may result from a further rise in LH levels. SpeculationPituitary secretion of gonadotropins, particularly FSH, in male children is a gradual phenomenon, antedating by several years the release of testosterone by the testis. This gradual rise may represent a progressive reduction in hypothalamic sensitivity to feedback by testicular steroids other than testosterone. In late childhood, rising FSH and LH levels may induce increased activity of the enzymes responsible for both synthesis and catabolism of testosterone. At puberty, an LH-mediated reduction in reductase activity might then result in testosterone accumulation and secretion. Introductionnadotropins and steroid hormones in man permits a The present availability of sensitive and specific isoreevaluation of the pituitary and Leydig cell changes tope displacement assays for circulating levels of gowhich initiate and maintain normal male sexual devel-

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Urinary Excretion of Luteinizing Hormone in Boys and Adult Men

Cited by 5 publications

References 0 publications

Urinary Excretion of Luteinizing Hormone in Girls and Normal Menstruating Women

Urinary Excretion of Luteinizing Hormone in Girls and Normal Menstruating Women

Human Chorion1c Gonadotrophin in Hydatidiform Moles

Pituitary-Gonadal Relations in Male Children and Adolescents

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