Urinary excretion of free norepinephrine and free epinephrine in patients with acute myocardial infarction in relation to its clinical course

Januszewicz, W; Sznajderman, M; Wocial, B; Preibisz, J

doi:10.1016/0002-8703(68)90229-9

Cited by 46 publications

(7 citation statements)

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“…This, however, depends on the renal flow. In a previous study, for example, patients with uncomplicated infarcts had higher urinary catecholamines than the patients with complications, since the latter group had a decreased renal flow (Klein et al, 1968;Januszewicz et al, 1968). Hayashi et al (1969) reported increased urinary catecholamine output in the first 48-72 hours after infarction and are in agreement with our results.…”

Section: Discussionsupporting

confidence: 92%

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Catecholamines and free fatty acids in myocardial infarction and angina.

Sharma¹

1977

J Clin Pathol

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SUMMARY Total urinary catecholamines and plasma free fatty acids (FFA) were estimated serially in 50 patients with myocardial infarction (A) and in 27 cases of angina (B). A group of 24 normal healthy subjects (C) were also studied as controls. Catecholamines were significantly high (p < 0 001) in group A in the first 48 hours after infarction as compared to group C. Group B did not show significant variation from the normals (C). FFA also tended to increase only in group A in the first 48 hours. Both the parameters had returned to normal by 72 hours. The significance of the findings is discussed.Considerable interest has been shown lately in the role of catecholamines and free fatty acids (FFA) in ischaemic heart disease. These have been characterised as important prognostic indicators of the severity of myocardial damage (Oliver et al., 1968;Januszewicz et al., 1968;Hayashi et al., 1969;McDonald et al., 1969;Taylor et al., 1969;Rutenberg et al., 1969). These biochemical measurements probably reflect generalised metabolic response to the stress of ischaemia. Cases of myocardial infarction and ischaemia without infarction (angina) differ primarily in the extent and degree of damage to the heart. The pathogenesis in both these clinical entities is apparently the same. The possible significance of catecholamines in the development of angina has been reviewed by Black and Prichard (1973). It is widely assumed that angina follows an imbalance in the oxygen supply and demand. Catecholamines increase demand by raising heart rate and force of contraction of the heart and by stimulating cardiac metabolism, commonly referred to as an oxygenwasting effect (Sarnoff et al., 1965). For example, the effect of raised FFA levels after isoprenaline infusion is to raise myocardial oxygen consumption significantly more than the effect of heart work alone (Mj0s, 1971). Accordingly, we estimated total urinary catecholamine excretion and plasma FFA in cases of acute myocardial infarction and angina. A group of normal, healthy, age-matched subjects were also studied for comparison. The results are reported.

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Section: Discussionsupporting

confidence: 92%

“…These have been characterised as important prognostic indicators of the severity of myocardial damage (Oliver et al, 1968;Januszewicz et al, 1968;Hayashi et al, 1969;McDonald et al, 1969;Taylor et al, 1969;Rutenberg et al, 1969). These biochemical measurements probably reflect generalised metabolic response to the stress of ischaemia.…”

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confidence: 99%

Catecholamines and free fatty acids in myocardial infarction and angina.

Sharma¹

1977

J Clin Pathol

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“…[9][10][11][12][13][14] Patients with acute myocardial infarction frequently exhibit excessive adrenergic activity as evidenced by an elevation of plasma and 24-hour urinary catecholamines. [15][16][17][18][19][20][21][22][23] It was therefore hypothesized that the abbreviated electromechanical systole characteristic of patients with myocardial infarction is a direct reflection of increased sympathetic nervous system activity. The.present investigation was designed to test this hypothesis.…”

Section: Ine Excretionmentioning

confidence: 99%

Shortening of Electromechanical Systole as a Manifestation of Excessive Adrenergic Stimulation in Acute Myocardial Infarction

et al. 1972

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“…A close relation between increased catecholamine excretion and development of cardiac arrhythmias has been suggested in patients with acute myocardial infarction.4 5 It is the purpose of this paper to examine the urinary excretion rate of catecholamines in patients with acute myocardial infarction and to analyze the factors which may increase urinary catecholamine excretion. Special attention is directed to the incidence of heart failure and cardiac arrhythmias in relation to catecholamine excretion rates.…”

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confidence: 99%

Urinary Catecholamine Excretion in Myocardial Infarction

Hayashi

Moss

1969

Circulation

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SUMMARYThe catecholamine excretion rates in urine were studied in three groups of patients with acute myocardial infarction. Group I patients had no complications. Group II patients had minor complications. In groups I and II urine was obtained during the first night of the patient's admission. Group III patients had major complications, and urine was collected during one episode of complications. Catecholamines were measured by spectrophotofluorometric assay using the trihydroxyindole method.A lack of elevation in basal catecholamine excretion in patients without complications and an elevated catecholamine excretion in those with complications suggest that myocardial necrosis or ischemia per se is not responsible for increased catecholamine excretion and that the increase in catecholamine excretion may reflect the presence of complicating factors.Recurrent or persisting chest pain, pulmonary congestion or edema, and ventricular arrhythmias were almost always associated with elevated catecholamine excretion. Although in some cases a causal relationship of these complications with observed increase in catecholamine excretion is suggested, further study is required for a definitive conclusion.

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Urinary excretion of free norepinephrine and free epinephrine in patients with acute myocardial infarction in relation to its clinical course

Cited by 46 publications

References 7 publications

Catecholamines and free fatty acids in myocardial infarction and angina.

Catecholamines and free fatty acids in myocardial infarction and angina.

Shortening of Electromechanical Systole as a Manifestation of Excessive Adrenergic Stimulation in Acute Myocardial Infarction

Urinary Catecholamine Excretion in Myocardial Infarction

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