Urinary excretion of deprenyl metabolites

Lengyel, József; Magyar, K.; Hollósi, I.; Bartók, Tibor; Báthori, Mária; Kalász, Huba; Fürst, Susanna

doi:10.1016/s0021-9673(97)00009-5

Cited by 37 publications

(15 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early metabolism studies have revealed the formation of MA and A by desalkylation, and urinary excretion of these metabolites in high amounts in humans [28,67,73], and rats [41,47,80,108]. DD was also detected in urine, although in much lower concentration than A derivatives [28,41,73,80].…”

Section: Metabolism and Excretion Of R-deprenylmentioning

confidence: 99%

“…DD was also detected in urine, although in much lower concentration than A derivatives [28,41,73,80].…”

Section: Metabolism and Excretion Of R-deprenylmentioning

confidence: 99%

“…High amount of para-hydroxylated amphetamine derivatives were excreted in the urine of rats treated with selegiline [33,41,108], and were also identified in human urine, although in somewhat lower concentration [73,87]. Small amount of para-hydroxy-DD was also found in rat urine [33].…”

Section: Metabolism and Excretion Of R-deprenylmentioning

confidence: 99%

See 2 more Smart Citations

R-Deprenyl: Pharmacological Spectrum of its Activity

et al. 2010

View full text Add to dashboard Cite

Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine potentiating and possible neuroprotective properties it has an established role in the treatment of parkinsonian patients. By inhibiting MAO-B enzyme, R-deprenyl decreases the formation of hydrogen peroxide, alleviating the oxidative stress also reduced by increased expression of antioxidant enzymes (superoxide dismutases and catalase) reported during chronic treatment. It was shown to prevent the detrimental effects of neurotoxins like MPTP and DSP-4. R-Deprenyl elicits neuroprotective and neuronal rescue activities in concentrations too low to inhibit MAO-B. It is extensively metabolized and some of the metabolites possess pharmacological activities, thus their contribution to neuroprotective properties was also suggested. The recently identified deprenyl-N-oxide is extensively studied in our laboratory. Effects other than neuroprotection, like influencing cell adhesion and proliferation cannot be neglected.

show abstract

Section: Metabolism and Excretion Of R-deprenylmentioning

confidence: 99%

“…DD was also detected in urine, although in much lower concentration than A derivatives [28,41,73,80].…”

Section: Metabolism and Excretion Of R-deprenylmentioning

confidence: 99%

See 1 more Smart Citation

R-Deprenyl: Pharmacological Spectrum of its Activity

et al. 2010

View full text Add to dashboard Cite

show abstract

“…RM,O and slope values are proper characteristics of the lipophilicity as it was discussed by Biagi et al (19) in details. The slope of the lines and the RM,O values (that is the RM calculated for 0% of the organic modifier) are given in Figures.…”

Section: Compounds (mentioning

confidence: 90%

Chromatographic investigation and computer simulation of L-deprenyl metabolism

Tarjányi

Kalász

Hollósi³

et al. 1998

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

“…L-Deprenyl and its major metabolites (L-nordeprenyl, L-methamphetamine, and L-amphetamine) can be determined in serum and urine using various separation methods, such as gas chromatography (GC) [4,5], gas chromatography-mass spectrometry (GC-MS) [6,7], high-performance liquid chromatography (HPLC) [8,9], HPLC-MS [10][11][12], and capillary electrophoresis [13,14]. Specificity for the parent compound is given by the use of selected ion monitoring of either GC-MS or HPLC-MS.…”

Section: Introductionmentioning

confidence: 99%

HPLC analysis and detection ofl-deprenyl

Csomor¹,

Laufer²,

Pöstényi³

et al. 2014

Acta Chromatographica

View full text Add to dashboard Cite

Summary. L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

show abstract

Urinary excretion of deprenyl metabolites

Cited by 37 publications

References 20 publications

R-Deprenyl: Pharmacological Spectrum of its Activity

R-Deprenyl: Pharmacological Spectrum of its Activity

Chromatographic investigation and computer simulation of L-deprenyl metabolism

HPLC analysis and detection ofl-deprenyl

Contact Info

Product

Resources

About