Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs

Fieten, Hille; Hugen, S.; Ingh, T.S.G.A.M. van den; Hendriks, W.H.; Vernooij, J.C.M.; Bode, P.; Watson, Adrian; Leegwater, P.A.J.; Rothuizen, J.

doi:10.1016/j.tvjl.2013.03.003

Cited by 18 publications

(24 citation statements)

References 14 publications

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“…In Labrador retrievers, the urinary copper/zinc ratio in a single urine sample was significantly associated with hepatic copper concentration. However, due to overlap in urine copper/zinc ratio between dogs with normal and high hepatic copper, the diagnostic value of this parameter is limited . Copper in serum does not correlate with hepatic copper concentration, and, currently, other possible biomarkers for copper status in the dog, including ceruloplasmin, are under investigation in our lab.…”

Section: Laboratory Diagnosismentioning

confidence: 98%

“…Parallel to the use of urine copper excretion in therapeutic monitoring in Wilson's disease, urinary copper and zinc excretion in relation to hepatic copper concentration was evaluated for use as a noninvasive screening tool for copper . In Labrador retrievers, the urinary copper/zinc ratio in a single urine sample was significantly associated with hepatic copper concentration.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

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New canine models of copper toxicosis: diagnosis, treatment, and genetics

Fieten

Penning

Leegwater

et al. 2014

Annals of the New York Academy of Sciences

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The One Health principle recognizes that human health, animal health, and environmental health are inextricably linked. An excellent example is the study of naturally occurring copper toxicosis in dogs to help understand human disorders of copper metabolism. Besides the Bedlington terrier, where copper toxicosis is caused by a mutation in the COMMD1 gene, more complex hereditary forms of copper-associated hepatitis were recognized recently in other dog breeds. The Labrador retriever is one such breed, where an interplay between genetic susceptibility and exposure to copper lead to clinical copper toxicosis. Purebred dog populations are ideal for gene mapping studies, and because genes involved in copper metabolism are highly conserved across species, newly identified gene mutations in the dog may help unravel the genetic complexity of different human forms of copper toxicosis. Furthermore, increasing knowledge with respect to diagnosis and treatment strategies will benefit both species.

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Section: Laboratory Diagnosismentioning

confidence: 98%

Section: Laboratory Diagnosismentioning

confidence: 99%

New canine models of copper toxicosis: diagnosis, treatment, and genetics

Fieten

Penning

Leegwater

et al. 2014

Annals of the New York Academy of Sciences

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“…The most common toxic injury causing CH in dogs is a consequence of hepatic copper (Cu) excess . Copper‐associated CH (CuCH) may develop in any breed, including mixed breeds, but the Bedlington Terrier (BT), Dalmatian, Labrador Retriever (LR), Doberman Pinscher, and West Highland White Terrier are predisposed.…”

Section: Etiologymentioning

confidence: 99%

“…Specific criteria for the diagnosis of immune‐mediated hepatitis in dogs have not been developed. An immune basis in some dogs with idiopathic CH is suggested by several criteria (Table ) which include the presence of lymphocytic infiltrates in the liver, abnormal expression of major histocompatibility complex class II proteins, positive serum autoantibodies, familial history of liver disease, association with other immune‐mediated disorders, female predisposition, and favorable response to immunosuppression . A presumptive clinical diagnosis of immune‐mediated CH in the dog requires elimination of other etiologies and a favorable response to immunosuppressive treatment.…”

Section: Etiologymentioning

confidence: 99%

“…D‐penicillamine (D‐Pen) is the Cu chelator of choice (Table ). This drug binds hepatic Cu which subsequently is eliminated in urine . In addition, D‐Pen increases metallothionein in hepatocytes (detoxifying intracellular Cu) and enterocytes (facilitating fecal elimination) and has mild anti‐inflammatory and anti‐fibrotic properties .…”

Section: Treatmentmentioning

confidence: 99%

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ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Webster

Cullen

Penninck

et al. 2019

Veterinary Internal Medicne

198

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This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical research in hepatology in dogs. It was generated from expert opinion and information gathered from searching of PubMed for manuscripts on CH, the Veterinary Information Network for abstracts and conference proceeding from annual meetings of the American College of Veterinary Medicine and the European College of Veterinary Medicine, and selected manuscripts from the human literature on CH. The panel recognizes that the diagnosis and treatment of CH in the dog is a complex process that requires integration of clinical presentation with clinical pathology, diagnostic imaging, and hepatic biopsy. Essential to this process is an index of suspicion for CH, knowledge of how to best collect tissue samples, access to a pathologist with experience in assessing hepatic histopathology, knowledge of reasonable medical interventions, and a strategy for monitoring treatment response and complications.

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