Urinary Excretion of Certain Amino Acids During ACTH and Cortisone Treatment of Rheumatoid Arthritis.

Brodie, Emily C.; Wallraff, Evelyn B.; Borden, Alice L.; Holbrook, W. Paul; Stephens, C. A. L.; Hill, D. F.; Kent, L J; Kemmerer, A. R.

doi:10.3181/00379727-75-18172

Cited by 24 publications

(2 citation statements)

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“…To be certain in the selection of the latter, however, the levels of other amino acids in RA require confirmation as previous investigations have only agreed on abnormally low serum histidine. [12][13][14][15] It can be concluded that there is a trend towards a reduction in the distribution volume of a histidine load in patients with RA. This occurs in conjunction with a reduction in serum half life but no change in clearance.…”

Section: Discussionmentioning

confidence: 99%

Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritis.

Sitton

Dixon

Astbury

et al. 1988

Annals of the Rheumatic Diseases

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HertsSUMMARY To investigate the cause of low serum histidine in rheumatoid arthritis (RA) single oral and intravenous doses of L-histidine were administered to patients with active RA, and to an equal number of age and sex matched control subjects. In the first study 13 patients and their controls received a 100 mg kg-1 dose of L-histidine as an aqueous slurry. Significant differences were seen in body weight, predose baseline serum histidine concentration, Cmax, t,½, and area under curve, AUCOo In a second study six patients and six controls each received a 50 mg kg-1 dose of L-histidine both orally and intravenously on two separate occasions. The patients with RA had a lower baseline serum histidine concentration, a lower volume of distribution, and a shorter plasma half life than the controls, but these differences were not statistically significant. No difference was seen in bioavailability or clearance. Low serum histidine in RA is unlikely to be due to malabsorption from the gut, uptake by abnormal gut flora, or increased metabolism.

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Section: Discussionmentioning

confidence: 99%

Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritis.

Sitton

Dixon

Astbury

et al. 1988

Annals of the Rheumatic Diseases

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show abstract

“…Decreases in circulating eosinophils and knee blood-flow were maximal at 24 to 48 hr. Brodie et al (199) reported that among patients with rheuma toid arthritis who were medicated with ACTH, there was a highly significant increase in urinary excretion of free threonine, lysine, and tyrosine ; whereas, in cortisone-treated patients, there was excretion of significant amounts of threonine and tyrosine, but urinary lysine excretion was not significantly increased. On the other hand, arginine excretion was not significantly affected by either.…”

Section: Hormones In Rheumatic Diseasementioning

confidence: 94%