Urinary Excretion of Brush-Border Antigen Revealed by Monoclonal Antibody: Early Indicator of Toxic Nephropathy

Renal impairment caused by chronic occupational chromate exposure

“…This result is in agreement with the previous reports (Wang et al 1994;Liu et al 1998). Francine and Mutti (Franchini et al 1978;Mutti et al 1985) described nephrotoxicity in workers of chromate-producing, tannery, chrome plating, and welding plants as indicated by an increased frequency of enzymuria and proteinuria. Lindberg and Vesterberg (Lindberg and Vesterberg 1983a, b) also observed a dose-response curve in urinary 2 M level in the workers who worked for chromate-producing plants.…”

Urinary Excretion of Podocalyxin Indicates Glomerular Epithelial Cell Injuries in Glomerulonephritis

“…Among several noninvasive procedures introduced to determine the sites of renal diseases, immunological methods have been employed to detect site-specific renal antigens in urine samples and found useful in identifying tubular antigens in the urine of patients experiencing rejection of renal transplantation or drug toxicity [10][11][12][13], However, no simple and noninvasive clinically applicable procedure is available to detect injuries of glomeruli or glomerular epithelial cells. Our new approach described here satisfactorily detects urinary podocalyxin excretion.…”

Urinary N -acetyl-β-glucosaminidase as an indicator of renal dysfunction in electroplating workers

“…However, this does not mean that this injury does not occur. The question as to whether chronic exposure to chromium compounds can induce nephrotoxic eects remains controversial [4,11,12,15,20,27,28]. Low-molecular-weight proteinuria in chromium workers arises as a result of chronic low-level exposure to chromium [11].…”