Urinary excretion of and alanine aminopeptidase in patients receiving amikacin or cis-platinum

Diener, U.; Knoll, E.; Langer, Bruno; Rautenstrauch, H; Ratge, D.; Wisser, H.

doi:10.1016/0009-8981(81)90373-9

Cited by 79 publications

(29 citation statements)

References 14 publications

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“…In patients treated with some antineoplastic agents, nephrotoxic side-effects are observed [2,3,6,8,9,12,14,15,19,30,32,33,35], The question is whether nephrotoxic effects occur in hospital workers who are occupationally ex posed to antineoplastic agents. Up to now, no such data have been published.…”

Section: Discussionmentioning

confidence: 99%

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Occupational exposure to antineoplastic agents and parameters for renal dysfunction

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Verplanke

Herber

et al. 1997

International Archives of Occupational and Environmental Health

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To study the nephrotoxic effects of occupa tional exposure to antineoplastic agents, the early renal effect parameters retinol-binding protein (RBP) and albumin (ALB) were determined in the urine of 11 hospital workers involved in the preparation and ad ministration of antineoplastic agents and in 23 hospital workers not involved in drug handling, who served as nonexposed controls. No significant difference was found between the exposed group and the nonexposed control group with respect to the early renal effect parameters RBP and ALB. Although it was demon strated that the hospital workers were exposed to cyclophosphamide (CP) and probably other antineoplastc agents, the results of the present study show that these exposure levels did not cause nephrotoxic effects.

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Section: Discussionmentioning

confidence: 99%

“…These parameters are widely used in occupational medicine for the detec tion of nephrotoxic effects in workers exposed to chem icals [16,35]. They are also applied clinically to control nephrotoxic side-effects of drugs such as aminoglyco sides [3] and antineoplastic agents like cisplatin [2,3,6,8,9,12,14,15,19,30,32,33,35].…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to antineoplastic agents and parameters for renal dysfunction

Sessink

Verplanke

Herber

et al. 1997

International Archives of Occupational and Environmental Health

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“…Normal serum contains only one isoenzyme, while in liver, biliary or pancreatic disease additional fractions are found. The enzyme is found in urine [16].…”

Section: Markers For Assessment Of Renal Damagementioning

confidence: 99%

Renal Enzymes and Microglobulins in Patients with Rheumathoid Arthritis

Spasovski¹

2014

J Nephrol Ther

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“…Unter Cisplatintherapie ist z. B. die Alaninaminopeptidase-Ausscheidung höher als die N-Acetyl-ß-Z>-glucosaminidase-Ausscheidung, wäh-rend sich dies bei Amikacin-Therapie umgekehrt verhält (13 (14). Erforderlich sind stets Angaben der diagnostischen Validitätskenngrößen Sensitivität, Spezifität, Effizienz.…”

Section: Nephrotoxizitätunclassified

Harnenzyme im Experiment und in der Klinik. Bericht über ein Symposium der Humboldt-Universität Berlin und des Bezirkskrankenhauses Frankfurt/Oder in Frankfurt/Oder (DDR), 22.-25. 4. 1987

Jung

Burchardt²

1987

Clinical Chemistry and Laboratory Medicine

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Zusammenfassung: Es wird über ein Symposium berichtet, das sich ausschließlich der Problematik "Harnenzyme" widmete. Auf dem Symposium mit 58 Teilnehmern aus 10 Ländern wurde in 39 Vorträgen der aktuelle Wissensstand der Harnenzymdiagnostik von der Grundlagenforschung bis zur klinischen Anwendbarkeit dargelegt und diskutiert. Der Bericht faßt die wesentlichen Punkte der Vorträge und Diskussionen zusammen. Urine enzymes in research and in the clinic Report on the Symposium of the Humboldt-Universität Berlin and the Bezirkskrankenhaus Frankfurt l O der Frankfurt/Oder, April 22-25, 1987Summary: The Symposium was dedicated exclusively to the subject of urine enzymes. Thirty nine lectures were given, in which 58 participants from 10 countries presented and discussed our present state of knowledge in the field of urine enzyme diagnosis, covering all aspects from fundamental research to its clinical application. This report summarizes the essential points of interest that arose from the lectures and discussions.Vortragende:

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Urinary excretion of and alanine aminopeptidase in patients receiving amikacin or cis-platinum

Cited by 79 publications

References 14 publications

Occupational exposure to antineoplastic agents and parameters for renal dysfunction

Occupational exposure to antineoplastic agents and parameters for renal dysfunction

Renal Enzymes and Microglobulins in Patients with Rheumathoid Arthritis

Harnenzyme im Experiment und in der Klinik. Bericht über ein Symposium der Humboldt-Universität Berlin und des Bezirkskrankenhauses Frankfurt/Oder in Frankfurt/Oder (DDR), 22.-25. 4. 1987

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