1985
DOI: 10.1203/00006450-198502000-00010
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Urinary Excretion of an Isomer of Bilirubin during Phototherapy

Abstract: Lumirubin, a water-soluble photoproduct of bilirubin formed in vivo during phototherapy, is excreted in the urine. In premature infants with little or no bilirubin conjugating activity, lumirubin is the principal yellow pigment found in the urine during phototherapy. The clearance rate of lumirubin in nine premature infants varied from 0.05 to 0.65 ml/min and increased with postconceptional age in parallel with increased creatinine clearance rate. The amount of lumirubin excreted per 24 h was estimated to be f… Show more

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Cited by 26 publications
(17 citation statements)
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“…[Note that in Fig. 1 a the peak areas do not reflect the relative concentrations of the bilirubin isomers, because of different molar extinction coefficients at 465 nm (21).] However, lumirubin is cleared from the serum more rapidly than is the configurational isomer.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…[Note that in Fig. 1 a the peak areas do not reflect the relative concentrations of the bilirubin isomers, because of different molar extinction coefficients at 465 nm (21).] However, lumirubin is cleared from the serum more rapidly than is the configurational isomer.…”
Section: Discussionmentioning
confidence: 99%
“…However, serial sampling at 15-20 min intervals for 180 min from 14 individual fetuses (91-139 days) showed that TSH was secreted in a markedly exaggerated pulsatile manner compared to that observed after birth. The mean amplitude of TSH pulses fell (p < 0.005) from 5.9 2 8.1 pU/ml in the fetuses to 2.1 + 1.1 pU/ml in five neonatal lambs (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) days) and to 1.5 f 0.4 pU/ml in three adult nonpregnant ewes. The mean pulse frequency for the 14 fetuses was 0.7 + 0.3 pulses/h and was reduced (p < 0.001) to 0.3 + 0.1 pulseslh in lambs and to 0.3 f 0.1 pulses/h in the ewes.…”
mentioning
confidence: 99%
“…Identification of the photoisomers was based on Chromatographie retention times. Extinction coefficients of photoisomers have been reported by several authors (2,29,30) but the values do not always agree. As we used different HPLC separation conditions, the detector response was not corrected for absorption differences of photoisomers at this wavelength, and the results are expressed as peak area.…”
Section: High Performance Liquid Chromatographymentioning
confidence: 90%
“…Some of the (EE)‐C change (EZ)‐C for thermal and/or catalytic (E→Z) reversion in urine, like configurational photoisomers. The total amounts of these photoisomers in urine are very small compared to the amounts in serum, but these photoisomers in urine can be detected by using high‐performance liquid chromatography (HPLC) 1–4 .…”
mentioning
confidence: 99%
“…Configurational photoisomers include (ZZ)-BR, (EZ)-BR and (ZE)-BR, and structural photoisomers include (EZ)-C and (EE)-C. Some BR photoisomers, which had been very low in urine levels before phototherapy, have been detected in urine of neonates with hyperbilirubinemia during phototherapy. [1][2][3][4] Both serum (EZ)-BR and (ZE)-BR are excreted in urine, but serum (ZZ)-BR is not directly excreted in urine because of its hydrophobicity. 2 Detected (ZZ)-BR in the urine is reverted from urine (ZE)-/(EZ)-BR.…”
mentioning
confidence: 99%