Urinary Excretion of 17-Hydroxy-Corticosteroids and 17-Ketosteroids in Healthy Subjects, in Relation to Sex, Age, Body Weight and Height

Borth, R; Linder, A. Elizabeth; Riondel, A. M.

doi:10.1530/acta.0.0250033

Cited by 72 publications

(21 citation statements)

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“…We have confirmed in our labor atory that this ratio of 17-KS/17-OHCS progressively declines with increasing age in healthy men ranging in age from 20 to 80 [Abbo, 1966). Furthermore, since 17-KS and 17-OHCS excretion rates depend to some extent on body weight and height [Borth, Linder and Riondel, 1957), their ratio would, to a first order of ap proximation, eliminate this dependence. One would therefore expect…”

supporting

confidence: 76%

“…Since the production and excretion of 17-hydroxycorticosteroids (17-OHCS) does not appreciably decline with age (Borth, Linder and Riondel, 1957; Kelson, 1960;Pincus, 1960; Samuels, 1956; West, Simons, Carter, Kumagai and Englert, 1961;Romanoff, Morris, Welch, Rodrigues and Pincus, 1961), the ratio of 17-KS to 17-OHCS would be expected to decline with increasing age. It has been shown that this ratio progressively declines with increasing age in post-menopausal women (Marmorston, Lewis, Bernstein, Sobel, Kuzma, Alexander, Magidson and Moore, 1957; Sobel and Marmorston, 1958; Sobel, 1960).…”

mentioning

confidence: 99%

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Weight-Lifting and Adrenal Cortex Function in Man

Abbo¹

1966

Geront clin

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supporting

confidence: 76%

mentioning

confidence: 99%

Weight-Lifting and Adrenal Cortex Function in Man

Abbo¹

1966

Geront clin

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“…T h e r e were slight differences between the behavioral groups (Table 1) in age, sex, body weight, degree of illness and duration of hospitalization (20). These factors may have affected plasma hormone levels but probably had less relation than behavioral reaction to the extent of change in these levels during the procedure.…”

Section: Discussionmentioning

confidence: 91%

Psychologic Correlates of Growth Hormone and Adrenal Secretory Responses of Patients Undergoing Cardiac Catheterization

Greene

Conron

Schalch

et al. 1970

Psychosomatic Medicine

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Twenty-two patients were studied during hospital admission for cardiac catheterization. Two independent observers rated their behavior at 15-min intervals over the 3-hour catheterization procedure in categories of affect, arousal and degree of interpersonal engagement. These rated data were used together with information obtained from retrospective interviews to assign each patient to one of the behavioral groups designated anxious-engaged, anxious-not engaged, depressed and calm. Plasma levels of growth hormone, cortisol, free fatty acid and glucose were determined every 30 min during the procedure. Free fatty acid levels rose appreciably in all patients. Calm and depressed patients showed no significant increases in plasma levels of either growth hormone or cortisol. Anxious-engaged patients showed elevations of cortisol but no elevation of growth hormone. Anxious-not engaged patients showed elevations of both growth hormone and cortisol. The several patterns of hormonal change may reflect different neural organizations underlying the several types of coping behavior.Plasma growth hormone levels in man are labile and have been shown to increase in response to different stimuli such as insulin-induced hypoglycemia, surgical pro-

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“…Urinary 17-hydroxycorticosteroid deter¬ mined before operation by the method of Appelby, Gibson, Norymberski & Stubbs (1955) averaged 65-3 mg./day; normal values for a man of this age are 5-19 mg./day with a mean of 10 mg./day (Borth, Linder & Riondel, 1957). Histological examina¬ tion of the adrenal glands removed at operation revealed bilateral hyperplasia.…”

Section: Clinical Datamentioning

confidence: 96%

The Metabolism of [4-14c]-Progesterone by Adrenocortical Tissue From Patients With Cushing's Syndrome

Ward¹,

Grant²

1963

Journal of Endocrinology

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The metabolism of [4-14C]-progesterone in vitro by adrenocortical tissue from three patients with Cushing's syndrome has been studied. The glands of two of these patients were hyperplastic and the third patient, a severely virilized girl, had a large adrenal tumour. Slices taken for study from the hyperplastic glands contained 'clear' fascicular and 'compact' reticular cells. The tumour slices were 'clear' cells.The major metabolites in each case were 17\g=a\-hydroxyprogesterone, 16\g=a\-hydroxyprogesterone,11\ g=b\ -hy dr ox y andr os t -4-ene-3, 17-di one and corticosterone. Small amounts of 11-deoxycorticosterone, androst-4-ene-3,17\x=req-\ dione and testosterone were also formed.The production of 16\g=a\-hydroxyprogesterone and testosterone from progesterone by adult human adrenal cortex tissue has not previously been described.The results support the view that adrenal androgens may be synthesized in both fascicular and reticular cells, in contradiction to the older view that the zona reticularis is the site of androgen biosynthesis.

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Urinary Excretion of 17-Hydroxy-Corticosteroids and 17-Ketosteroids in Healthy Subjects, in Relation to Sex, Age, Body Weight and Height

Cited by 72 publications

References 0 publications

Weight-Lifting and Adrenal Cortex Function in Man

Weight-Lifting and Adrenal Cortex Function in Man

Psychologic Correlates of Growth Hormone and Adrenal Secretory Responses of Patients Undergoing Cardiac Catheterization

The Metabolism of [4-14c]-Progesterone by Adrenocortical Tissue From Patients With Cushing's Syndrome

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