Urinary Excretion of 17-Hydroxy-20-Oxosteroids in Normal Health and in Rheumatoid Arthritis

Appleby, Joan I.; Norymberski, J. K.

doi:10.1136/ard.14.2.172

Cited by 13 publications

(1 citation statement)

References 16 publications

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“…lower than normal, but this figure has now been revised. Appleby and Norymberski (1955) studied the 21-deoxyketols and concluded that these were normal in patients with rheumatoid arthritis; but in the only very acute case of rheumatoid arthritis in their series the 21deoxyketols were approximately twice as high as in any other patient in the entire series. It would appear that there is considerable evidence suggestive of abnormal adrenal function in patients with rheumatoid arthritis, but no one is in a position to define the exact status of pituitary adrenal function in such patients, so that many studies such as Dr. Hill's are needed to clarify this problem.…”

Section: Isolation Of Hyaluronic Acid From Synovial Fluid Bymentioning

confidence: 98%

American Rheumatism Association: Proceedings of Second Interim Scientific Session, 1955

1956

Annals of the Rheumatic Diseases

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Section: Isolation Of Hyaluronic Acid From Synovial Fluid Bymentioning

confidence: 98%

American Rheumatism Association: Proceedings of Second Interim Scientific Session, 1955

1956

Annals of the Rheumatic Diseases

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Studies on adrenal cortical activity in patients with rheumatoid arthritis: The diurnal pattern and twenty-four hour levels of urinary total 17-hydroxycorticosteroids and 17-ketosteroids

Hill

Holley

Ulloa

et al. 1959

Arthritis & Rheumatism

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A h . These studies were supported by funds from the National I d t u t e of Arthritis and Metabolic Diseases, National Institutes of Health, U.S.P.H.S., and the A. H . Robins Company, Inc. Three of the authors (A. V., L. L. H. and J. H . McN.) are Trainees of the X&nal Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U.S.P.H.S. 114ADRENAL CORTICAL ACXIVITY M RHEUMATOID ARTHRITIS 115 els have been found by several investigators,l2*21-23 while another reported low pIasma corticoid concentrations.2* Still another study demonstrated values in the upper limits of normal using the blue tetrazolium and phenylhydrazine reactions. These were associated with high absolute and relative values for "F-like" substances in plasma.2s These and other performed on patients with rheumatoid arthritis suggest that while gross adrenal cortical secretory activity is apparently within normal limits, subtle, yet signScant, deviations from normal may occur.Many of the foregoing studies have utilized changes in urinary 17-ketosteroid or unconjugated ll-oxy-or 17-hydroxycorticosteroid levels as indicators of adrenal cortical activity. It is now well appreciated that these indexes are either not entirely s p e d c (urinary excretion of 17-ketosteroids in males) or only partial (unconjugated corticosteroid levels) indicators of adrenal cortical activity. The availability of more precise technics for meas-

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Über das Verhalten der Steroide der Nebennierenrinde und des ACTH-Testes bei der menschlichen Silikose

Hilgers

1958

Die Staublungenerkrankungen

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Urinary Excretion of 17-Hydroxy-20-Oxosteroids in Normal Health and in Rheumatoid Arthritis

Cited by 13 publications

References 16 publications

American Rheumatism Association: Proceedings of Second Interim Scientific Session, 1955

American Rheumatism Association: Proceedings of Second Interim Scientific Session, 1955

Studies on adrenal cortical activity in patients with rheumatoid arthritis: The diurnal pattern and twenty-four hour levels of urinary total 17-hydroxycorticosteroids and 17-ketosteroids

Über das Verhalten der Steroide der Nebennierenrinde und des ACTH-Testes bei der menschlichen Silikose

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