Urinary Epitectin (MUC-1 Glycoprotein) in the Menstrual Cycle and Interstitial Cystitis

Erickson, Deborah; Mast, Stuart; Ordille, Sarah; Bhavanandan, V. P.

doi:10.1097/00005392-199609000-00026

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Speci c glycoconjugates and carbohydrate-binding proteins, i.e., lectins, play important roles in animal development, physiology, and various pathological states. We are investigating the role of bladder epithelial glycoconjugates in bladder disorders such as interstitial cystitis (1)(2)(3). In continuation of these studies, histochemical examination of rabbit and human bladder sections revealed strong calcium-independent binding of b -Dgalactose neoglycoconjugates (4).…”

Section: Introductionmentioning

confidence: 99%

Signature Sequences for the Galectin-4 Subfamily

Jiang¹,

Puch²,

Guo³

et al. 1999

IUBMB: Life

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Galectins are a distinct family of animal lectins that have a cation-independent affinity for beta-galactoside sugars and share characteristic amino acid sequences. The cDNA encoding rabbit bladder galectin-4 has been cloned and sequenced (GenBank accession no. AF091738). The deduced 328 amino acid sequence predicts a multidomain structure consisting of an N-terminal peptide (19 residues) and two carbohydrate recognition domains (130 residues each) connected by a linker region (49 residues). Comparison of rabbit galectin-4 with related proteins reveals that two peptide motifs, M-A-F/Y-V-P-A-P-G-Y-Q-P-T-Y-N-P-T-L-P-Y in the N terminus and A-F-H-F-N-P-R-F-D-G-W-D-K-V-V-F in the first carbohydrate recognition domain are highly conserved in human, pig, rat, and mouse galectin-4 as well as in mouse galectin-6. The two peptide motifs are proposed here as the signature sequences to identify new members of the galectin-4 subfamily.

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Section: Introductionmentioning

confidence: 99%

Signature Sequences for the Galectin-4 Subfamily

Jiang¹,

Puch²,

Guo³

et al. 1999

IUBMB: Life

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“…Concernant les métabolites urinaires des glycosaminoglycanes, il n'existe pas de consensus quant au taux d'acide hyaluronique urinaire retrouvé dans les cystites interstitielles, diminué pour les uns [26], augmenté pour les autres [27]. La variabilité de ces résultats rend nécessaire des études de corrélation entre les biopsies de vessie et le taux urinaire de GAG retrouvé.…”

Section: Marqueurs Urinairesunclassified

Cystite interstitielle

Ferchaud

Deval²

2006

Pelv Perineol

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Interstitial Cystitis: Update on Etiologies and Therapeutic Options

Erickson¹

1999

Journal of Women's Health & Gender-Based Medicine

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Interstitial cystitis (IC) is a syndrome of pelvic and/or perineal pain, urinary urgency, and frequency. It is now agreed that IC is a multifactorial syndrome, not a single condition. A variety of etiologies for IC have been proposed, but none has been definitively proven. Since the etiologies for IC remain unknown, the current treatments are empiric. This article will review the major theories of etiology for IC and discuss the current treatment options with relevance to the proposed etiologies. No single treatment is effective for all IC patients. Therefore, the approach is to try different treatments, alone or in combination, until symptom relief is satisfactory. In some cases, none of the empiric IC treatments are successful. These patients require adjunctive pain management, and a small minority of IC patients resort to surgery if all other options fail.

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Urinary Epitectin (MUC-1 Glycoprotein) in the Menstrual Cycle and Interstitial Cystitis

Abstract: Decreased mean urinary epitectin levels may reflect a cause (epithelial mucin deficiency) or a consequence of interstitial cystitis.

Cited by 3 publications

References 13 publications

Signature Sequences for the Galectin-4 Subfamily

Signature Sequences for the Galectin-4 Subfamily

Cystite interstitielle

Interstitial Cystitis: Update on Etiologies and Therapeutic Options

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