Urinary epidermal growth factor receptor-binding growth factors in patients with cancers of the digestive tract

Chuang, Li‐Yeh; Hung, Wen‐Chun; Yang, Mei‐Li; Chang, Chun-Chang; Tsai, Jung‐Fa

doi:10.1016/0009-9120(94)00053-x

Cited by 17 publications

(19 citation statements)

References 13 publications

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“…HCC appears to be associated with hepatitis B and C virus infection and is common in patients with cirrhosis caused by chronic viral hepatitis (Jeng and Tsai, 1991;Sherlock and Dooley, 1993;Tsai et al, 1993Tsai et al, , 1994aTsai et al, -f, 1995Tsai et al, , 1996aTsai et al, ,b, 1997a (Maussier et al, 1990;Tsai et al, 1990Tsai et al, , 1991Tsai et al, , 1995Fujiyama et al, 1992;Sherlock and Dooley, 1993;Chuang et al, 1994;Colombo, 1995). Serum AFP is one of the most intensively studied tumour markers.…”

Section: Discussionmentioning

confidence: 99%

“…Transforming growth factors have been described in the urine of healthy adults and patients (Sherwin et al, 1983;Nishimura et al, 1986;Ranganathan et al, 1987;Yeh et al, 1987;Chuang et al, 1991Chuang et al, , 1994Coupes et al, 1994). Transforming growth factor-a can serve as a tumour marker and as a marker for malignant potential (Baldwin and Zhang, 1992;Lee et al, 1992;Chuang et al, 1994;Sherlock, 1994).…”

mentioning

confidence: 99%

“…Transforming growth factor-a can serve as a tumour marker and as a marker for malignant potential (Baldwin and Zhang, 1992;Lee et al, 1992;Chuang et al, 1994;Sherlock, 1994). However, the role of TGF-P1 as a diagnostic marker has never been clearly elucidated.…”

mentioning

confidence: 99%

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Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma

Tsai

Jeng²,

Chuang³

et al. 1997

Br J Cancer

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Summary To evaluate the diagnostic application of urinary transforming growth factor-o1 and serum a-fetoprotein (AFP) levels in hepatocellular carcinoma (HCC), TGF-,B1 and AFP were determined in 94 patients with cirrhotic HCC and in 94 sex-and age-matched patients with cirrhosis alone. TGF-01 and AFP levels in HCC were higher than in cirrhosis alone (P = 0.0001). There is an inverse correlation between TGF-f1 and log AFP (r = -0.292, P = 0.004). Multivariate analysis indicated that TGF-j1 and AFP were closely associated, in a dose-related fashion, with the development of HCC. Receiver-operating characteristic (ROC) curves were used to determine the optimal cutoff values of TGF-01 (50 gg g-1 creatinine) and AFP (100 ng ml-'). Both TGF-p1 and AFP showed a high specificity (99%) and positive likelihood ratio. The sensitivity was 53.1% for TGF-f1 and 55.3% for AFP. The determination of both markers in parallel significantly increased the diagnostic accuracy (90.1%) and sensitivity (84%), with a high specificity (98%) and positive likelihood ratio (40.0). In conclusion, TGF-f1 and AFP are independent tumour markers of HCC and may be used as complementary tumour markers to discriminate HCC from cirrhosis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma

Tsai

Jeng²,

Chuang³

et al. 1997

Br J Cancer

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“…Among these signals, TGFb plays a pivotal role in that, in addition to regulation of IgA isotype switching, it can mediate both cell cycle arrest and apoptosis in B cells (Chaouchi et al, 1995;Co man et al, 1989;Kehrl et al, 1986;Lomo et al, 1995). Our knowledge of the mechanisms of TGFb-induced apoptosis is still poor and results essentially from studies on hepatic cells (Chen and Chang, 1997;Choi et al, 1998;Chuang et al, 1994;Fan et al, 1996;Inayat-Hussain et al, 1997). Apoptosis is an active energy-dependent process which is characterized by morphological changes including loss of cell volume, plasma membrane blebbing and cell shrinkage, expression of phosphatidylserine on the outer lea¯et of the cell membrane, chromatin condensation, DNA fragmentation into oligo-nucleosomesized fragments and nuclear fragmentation (Cohen et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Role of caspases and possible involvement of retinoblastoma protein during TGFβ-mediated apoptosis of human B lymphocytes

et al. 1999

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In this study, we investigated the involvement of caspases in TGFb-induced apoptosis in human B cells. Our results show that TGFb-mediated nuclear fragmentation, observed in the Epstein ± Barr virus-negative Burkitt's Lymphoma cell line BL41, was abolished in the presence of the tripeptide caspase inhibitor ZVAD-fmk or the speci®c caspase-3 inhibitor DEVD-fmk. Other apoptotic manifestations such as cell shrinkage, surface phosphatidylserine expression and chromatin condensation were strongly inhibited by ZVAD-fmk but only partially by DEVD-fmk. This suggests that other caspases in addition to caspase-3 control these apoptotis-associated features. Speci®c activation of caspase-3 during TGFbinduced apoptosis was demonstrated by the DEVD-fmksensitive expression of the active p17 subunit of caspase-3 and by in vivo cleavage of PARP. In addition, TGFb treatment of BL41 promoted the expression of both dephosphorylated and truncated forms of the retinoblastoma protein. Inhibition of caspase-3 activity abolished both nuclear fragmentation and expression of the truncated retinoblastoma protein, without modifying the G1 cell cycle arrest induced by TGFb. Our data thus demonstrate that TGFb-induced apoptosis of lymphoma B lymphocytes is dependent on caspase activation and involves caspase-dependent cleavage of the retinoblastoma protein.

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“…Transforming growth factors have been described in the urine of healthy adults and patients (Sherwin et al, 1983;Nishimura et al, 1986;Ranganathan et al, 1987;Yeh et al, 1987;Chuang et al, 1991Chuang et al, , 1994Coupes et al, 1994). Transforming growth factor alpha can serve as a tumour marker and as a marker for malignant potential (Yeh et al, 1987;Lee et al, 1992;Chuang et al, 1994).…”

mentioning

confidence: 99%

Elevated urinary transforming growth factor-β1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma

Tsai

Jeng²,

Chuang³

et al. 1997

Br J Cancer

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Summary To assess the clinical relevance of transforming growth factor-jl (TGF-jl) in hepatocellular carcinoma (HCC), urinary TGF-jl and serum a-fetoprotein (AFP) were determined in 94 patients with cirrhotic HCC, 94 age-and sex-matched patients with cirrhosis alone and 50 healthy adults. TGF-,1l level in HCC was higher than in cirrhosis alone or in healthy controls (each P = 0.0001). There is an inverse correlation between TGF-j1 and AFP levels (r = -0.292, P = 0.004). Significantly higher TGF-p1 level was found in HCC patients with worsening Child-Pugh stages, diffuse HCC, tumour size 2 3 cm, multilobular tumour and AFP < 20 ng ml-'. TGF-j1 level decreased after complete treatment with transcatheter arterial chemoembolization (P = 0.0001). The median survival in HCC patients with raised TGF-j1 was shorter than those with normal TGF-,lB (P = 0.018). Multivariate analysis indicated that TGF-p1 and AFP were significantly correlated with the presence of HCC. In addition, TGF-p1 could be used as a diagnostic marker for HCC, particularly in tumours with low AFP production. In conclusion, elevated urinary TGF-j1 level is a tumour marker and predictor of poor survival for cirrhotic HCC.

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Urinary epidermal growth factor receptor-binding growth factors in patients with cancers of the digestive tract

Cited by 17 publications

References 13 publications

Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma

Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma

Role of caspases and possible involvement of retinoblastoma protein during TGFβ-mediated apoptosis of human B lymphocytes

Elevated urinary transforming growth factor-β1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma

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